HIV CO-INFECTIONS IN UGANDAAdministrative Supplement for Research and Capacity Building Efforts Related to Bioethical Issues (Admin Supp Clinical Trial Optional)

乌干达的艾滋病毒合并感染与生物伦理问题相关的研究和能力建设工作的行政补充（行政补充临床试验可选）

• 批准号: 10790042
• 负责人: Barbara Castelnuovo
• 金额: $ 13.19万
• 依托单位: INFECTIOUS DISEASES INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2024-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10790042
• 关键词: Address; Adolescent; Area; Award; Bioethical Issues; Bioethics; Child; Clinical Trials; Complex; Development; Discipline; Drug user; Educational Curriculum; Elderly; Ethical Theory; Ethics; Evaluation; Exposure to; Feedback; Grant; HIV; HIV Infections; Health; Hospitalization; Individual; Interview; Knowledge; Lactation; Learning Module; Mentors; Methods; Online Systems; Patients; Persons; Phase; Play; Population; Populations at Risk; Prostitution; Research; Research Activity; Research Ethics; Resource-limited setting; Role; Surveys; Teaching Materials; Training; Training Programs; Universities; Woman; co-infection; medical schools; practical application; pregnant; sexual minority men; transgender

Background: Knowledge of research ethics principles and their practical application and ethical theory are not consistently integrated in curriculum requirements in health disciplines training. Research in people living with HIV (PLWH) in resource limited settings (RLS) may pose additionally bioethical challenges for which it is imperative that trainees are exposed to research bioethical training before carrying out research activities Aim. We plan to develop a training program with a blended approach of class training, development of role-plays and case scenarios, and web-based modules to address gaps and equip trainees of the School of Medicine at Makerere University with knowledge in ethics principles in research with PLWH. Specific objectives 1. To understands the training needs in research bioethics for trainees in the area of HIV and co-infections. 2.To develop a short training curriculum comprising class training, including role plays and case scenarios and web-based modules for online training for trainees at the School of Medicine. 3.To pilot and evaluate the developed training, refine and complete the teaching material and content. At the end of the grant this content will be officially handed over to the School of Medicine and the course will be offered annually (post award) as part of the School of medicine training. Methods We plan to conduct a formative phase consisting in a survey of trainees, and in depth interviews, and coordinate the training material with the mentors and the implementation of the training. The findings will guide the development of the training material and content, focusing on complex and understudied populations within PLWH, such as children, adolescents, pregnant and lactating women, elderly people living with HIV, “most at risk population” (e.g. commercial sex workers, sexual minority men, transgender individuals, drug users), and very sick hospitalized patients. We will organize a pilot training course followed by a formal evaluation consisting of a survey and interviews with the trainees. Based on the feedback the training program will be refined and finalized and will be integrated in the teaching modules of the School of Medicine

背景：了解研究伦理原则及其实际应用和伦理 理论在卫生学科培训的课程要求中没有得到一致的整合。 在资源有限的情况下对艾滋病毒携带者(PLWH)进行的研究可能会提出 此外，还必须让受训者接触研究，以应对生物伦理挑战 开展研究活动前的生物伦理培训 瞄准。我们计划开发一种混合班级培训方法的培训计划， 开发角色扮演和案例情景，以及基于网络的模块，以弥补差距和 为Makerere大学医学院的实习生提供伦理知识 与PLWH一起研究的原则。 具体目标1.了解学员在研究生物伦理学方面的培训需求 艾滋病毒和混合感染的领域。2.制定包括课堂培训在内的短期培训课程， 包括为学员提供在线培训的角色扮演和案例场景以及基于Web的模块，网址为 医学院。3.对已开展的培训进行试点和评估，完善和完善 教材和内容。在拨款结束时，此内容将正式移交给 医学院和该课程将作为学院的一部分每年提供(职位奖励) 医学培训。 方法 我们计划进行一个形成阶段，包括对学员的调查和深入访谈， 并与导师协调培训材料和培训的实施。 调查结果将指导培训材料和内容的开发，重点放在复杂的 儿童、青少年、孕期和哺乳期等未得到充分研究的人群 妇女、艾滋病毒携带者、“高危人群”(例如，商业性工作者、 性少数族裔男子、变性人、吸毒者)和病情严重的住院病人。 我们将组织一个试点培训课程，然后进行正式评估，包括调查和 对实习生的采访。根据反馈意见，将改进培训计划，并 最后确定并将纳入医学院的教学单元