HIV CO-INFECTIONS IN UGANDA
乌干达的艾滋病毒合并感染
基本信息
- 批准号:10599163
- 负责人:
- 金额:$ 30.08万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-06-01 至 2024-09-30
- 项目状态:已结题
- 来源:
- 关键词:AccelerationAdultAfrica South of the SaharaAgingAreaCardiovascular DiseasesCaringCessation of lifeCommunicable DiseasesCryptococcal MeningitisDiabetes MellitusDiagnosisDiseaseEnsureFundingGrantHIVHIV InfectionsHeadHypertensionIndividualInstitutionInternationalKidney DiseasesLeadershipLiver FailureLung diseasesMalignant NeoplasmsMeningeal TuberculosisMentorsMentorshipModelingOpportunistic InfectionsPatientsPlayPostdoctoral FellowPrevalencePreventionProcessProductivityResearchScientistStudentsTrainingTraining ProgramsUgandaUniversitiesViralViral hepatitisWorkWritingagedantiretroviral therapyboneco-infectiondoctoral studentexperiencehigh riskmortalitypathogenpeerpost-doctoral trainingprograms
项目摘要
Increasing availability of antiretroviral therapy (ART) in sub-Saharan Africa (SSA) has led to
decreases in mortality rates. The WHO estimates that 940,000 million deaths were attributable
to HIV in 2017, with the majority caused by co-infecting pathogens.
Uganda still has a prevalence rate of 6.5% among adults aged 15-49 (UNAIDS). Many patients
still present late and often co-infected with opportunistic infections such as tuberculosis (TB)
and cryptococcal meningitis. Viral hepatitis (B & C) co-infection occurs in 2-10% and poses
challenges in terms of best anti-viral treatment, diagnosis, and prevention. Challenges present
also for HIV-infected individuals stable on ART, because they are at higher risk of “non AIDS”
non-communicable diseases, particularly hypertension, diabetes mellitus, renal disease,
pulmonary disease, cardiovascular disease, cancer, bone abnormalities and liver failure. HIV
infection itself also seems to be associated to an accelerated aging process.
The Infectious Diseases Institute (IDI) in Uganda is a Research and Care Center of
Excellence and has already established research programs in HIV and co-infections under
the previous Heads of Research (Y. Manabe, and A Kambugu, previous Program Director
and Uganda Program Director respectively). The current Head of Research (B Castelnuovo-
proposed Program Director in this Cycle), has worked closely with Dr Manabe and Dr
Kambugu for the last 10 years, when she was the Head of the Research Capacity Building
Unit and Deputy Head of Research.
We plan to train 9 master students, 2 PhD students and 5 post-doctoral students at Makerere
University, Uganda. Our previous 5-year cycle has solidified a core group of productive,
independent scientists through post-doctoral training who can now act as local mentors. We
will shift the leadership of the training program from the US to the Uganda Institution in order
to ensure sustainable research capacity building. We will also encourage a peer-to-peer
mentorship model among scientists with the same level of experience to expand the impact
of training. International mentors will still play a key role in overall mentorship of the local
experts particularly to expand research networks and to provide grant-writing support.
At the end of this 5-year training program, our overarching objective is to solidify a core group
of expert, productive, independent scientists who can promote sustainable capacity building
by garnering outside funding, continuing to mentor others including peers, and be recognized
as international, regional leaders and mentors in the area of HIV co-infections.
在撒哈拉以南非洲(SSA),抗逆转录病毒治疗(ART)的可获得性不断提高,导致
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Barbara Castelnuovo其他文献
Barbara Castelnuovo的其他文献
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{{ truncateString('Barbara Castelnuovo', 18)}}的其他基金
HIV CO-INFECTIONS IN UGANDAAdministrative Supplement for Research and Capacity Building Efforts Related to Bioethical Issues (Admin Supp Clinical Trial Optional)
乌干达的艾滋病毒合并感染与生物伦理问题相关的研究和能力建设工作的行政补充(行政补充临床试验可选)
- 批准号:
10790042 - 财政年份:2023
- 资助金额:
$ 30.08万 - 项目类别:
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