HIV CO-INFECTIONS IN UGANDA

背景：随着艾滋病综合护理方案在次级方案中的建立和扩大， 撒哈拉非洲（SSA）和相关的死亡率降低。有越来越多的 老年艾滋病毒感染者（OPLWH）。抗逆转录病毒疗法的推广降低了发病率 和死亡率，随后寿命增加，通过恢复免疫功能， 抑制病毒载量复制。然而，尽管预期寿命增加，长寿- 长期感染HIV和ART与临床衰老、慢性疾病 包括老年综合征，特别是虚弱和神经认知损伤。 目的：我们计划在OPLWH的研究领域培训一名研究员，作为该研究员的垫脚石。 职业发展道路，艾滋病毒护理和研究计划在IDI建立可扩展的工具， 艾滋病毒护理和研究方案，并试点和评估潜在的奖学金 该计划可以扩大与IDI合作，以获得由 马凯雷雷大学。 具体目标1.培训一名研究员在乌干达的妇女和卫生观察所进行研究。2. 调整和验证老年评估工具，特别是可扩展的筛查工具 用于治疗虚弱、身体功能和肌肉减少症。3.评估奖学金， 我们会进行改良的柯克帕特里克评估 方法：我们计划培训一名研究员在OPLWH进行研究，重点是 针对OPLWH临床护理的试点和测试工具，重点关注虚弱、身体和认知 功能 此外，该计划还建议调整和验证老年评估工具， OPLWH，专门针对虚弱，身体功能和肌肉减少症的可扩展筛选工具， OPLWH在乌干达。我们还将评估通过平板电脑进行自我收集的可行性， 认知功能、生活质量、日常工具性活动的简化验证工具 生活（IADL）、福尔斯史、抑郁症筛查和尿失禁。 最后，为了评估奖学金，我们将进行修改后的柯克帕特里克评估。征求 导师的经验教训，并确定在计划的 培训计划（D 71和D43在艾滋病毒和老年医学的研究，由博士Castelnuovo （Byakika）

Background: With the establishment and scale up of comprehensive HIV care programs in sub- Saharan Africa (SSA) and the related reduction in mortality. There is an increasing number of older people living with HIV (OPLWH). The scale up of ART has resulted in reduction in morbidity and mortality with a subsequent increased longevity, by restoring the immune function following suppression of viral load replication. However, despite this increased life expectancy, living long- term with HIV and ART is associated with an earlier onset of clinical aging, chronic conditions including geriatric syndromes in particular frailty, and neurocognitive impairment. Aim: We plan to train a fellow in the research area of OPLWH as a steppingstone to the fellow’s career development path, to the HIV-care and research program at IDI to build scalable tools for care of OPLWH for HIV-care and research program, and pilot and evaluate a potential fellowship program that can be scaled up in collaboration with the IDI to a full fellowship accredited by the Makerere University. Specific objectives 1. To train a research fellow to conduct research in OPLWH in Uganda. 2. To adapt and validate instruments for geriatric assessment, specifically scalable screening tools for frailty, physical function and sarcopenia for OPLWH in Uganda. 3.To evaluate the fellowship, we will conduct a modified Kirkpatrick evaluation. Methods: We plan to train a research fellow to conduct research in OPLWH with emphasis on piloting and testing tools for clinical care of OPLWH focusing on frailty, physical and cognitive function. Additionally, the program proposes to adapt and validate instruments for geriatric assessment of OPLWH, specifically scalable screening tools for frailty, physical function and sarcopenia for OPLWH in Uganda. We will also will evaluate the feasibility of self-collection through tablets using simplified validated tools for cognitive function, Quality of Life, Instrumental Activities of Daily Living (IADL), history of falls, screening for depression, and incontinence. Finally, to evaluate the fellowship, we will conduct a modified Kirkpatrick evaluation. Solicit mentors ‘experience, lessons learnt and identify gaps that should be addressed in the planned training program (D71 and D43 in research in HIV and geriatric medicine by Drs. Castelnuovo and Byakika)