CENTER FOR RESEARCH ON STRUCTURAL BIOLOGY OF INFECTIOUS DISEASES

传染病结构生物学研究中心

• 批准号: 10788160
• 负责人: KARLA SATCHELL
• 金额: $ 27.21万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10788160
• 关键词: 3-Dimensional; Bacteria; Basic Science; Biological; Biomedical Research; Black-legged Tick; Categories; Communicable Diseases; Emerging Communicable Diseases; Molecular; National Institute of Allergy and Infectious Disease; Organism; Powassan virus; Proteins; Research; Research Project Grants; Research Support; Role; Structure; Technology; pathogen; priority pathogen; programs; structural biology; three dimensional structure

To apply state-of-the-art, high-throughput structural biology technologies to experimentally characterize the three-dimensional atomic structure of targeted proteins on the NIAID Category A-C priority pathogens list and organisms causing emerging and re-emerging infectious diseases. This program also supports research projects that utilize the 3D structure information and experimental approaches to better characterize the molecular functional role of protein targets. The primary focus of the Center is pathogen proteins that are expected to have an important biological role and a potential impact on biomedical research.

应用最先进的高通量结构生物学技术，对NIAID A-C类优先病原体名单上的目标蛋白质以及导致新出现和再次出现的传染病的生物的三维原子结构进行实验表征。该计划还支持利用3D结构信息和实验方法更好地表征蛋白质靶标的分子功能作用的研究项目。该中心的主要重点是病原体蛋白，预计这些蛋白将在生物医学研究中发挥重要的生物学作用和潜在影响。