Conduct of studies to evaluate the toxic potential of C9-alkylbenzenes in laboratory animals

进行研究以评估 C9-烷基苯对实验动物的潜在毒性

• 批准号: 10788070
• 负责人: BARNEY SPARROW
• 金额: $ 398.49万
• 依托单位: BATTELLE MEMORIAL INSTITU
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-15 至 2023-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10788070
• 关键词: Adverse effects; Benzene; Chemicals; Data; Development; Environmental Exposure; Exposure to; Goals; Hazard Identification; Hazardous Chemicals; Health; Human; Inhalation; Laboratories; Laboratory Animals; Lung; Mission; Mus; Phase; Rattus; Risk Assessment; Risk Factors; Toxic effect; Toxicity Tests; Toxicology; Xylene; carcinogenicity; design; disorder prevention; exposure route; neurobehavioral; public health research; reproductive; sound

The goal of this project is to provide support of the Division of Translational Toxicology (DTT) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper conduct of toxicology studies is required to ensure that the resulting data are reliable. This project involves characterization of the toxicity of C9-alkylbenzenes, including 1,2,4-trimethylbenzene, 2-ethyltoluene, and mixed xylenes, following exposure via whole body inhalation. Humans are likely to be similarly exposed to these compounds via inhalation. The data from this project will be used in the development of sound, scientific conclusions about the potential toxicity and carcinogenicity of 1,2,4-trimethylbenzene, 2-ethyltoluene and mixed xylenes in rats and mice and ultimately supports the mission and goals of DTT and risk assessment activities of other federal agencies. In addition, the public can be adequately informed about risk factors arising from exposure to 1,2,4-trimethylbenzene, 2-ethyltoluene and mixed xylenes. Keywords: toxicity, inhalation, trimethylbenzene, ethyltoluene, xylene, lung

本项目的目标是为转化毒理学司（DTT）的危害识别活动提供支持，这些活动旨在预防因环境暴露于化学或物理制剂而引起的疾病或不良影响。毒性测试是公共卫生研究的一个重要方面，因为它有助于确定对人类健康有害的化学品。需要适当进行毒理学研究，以确保所得数据可靠。该项目涉及通过全身吸入接触C9烷基苯（包括1，2，4-三甲基苯、2-乙基甲苯和混合二甲苯）后的毒性特征。人类可能通过吸入类似地暴露于这些化合物。该项目的数据将用于制定关于1，2，4-三甲苯、2-乙基甲苯和混合二甲苯在大鼠和小鼠中的潜在毒性和致癌性的合理科学结论，并最终支持DTT的使命和目标以及其他联邦机构的风险评估活动。此外，公众可以充分了解接触1，2，4-三甲基苯、2-乙基甲苯和混合二甲苯所产生的风险因素。 关键词：毒性，吸入，三甲苯，乙基甲苯，二甲苯，肺