Administrative supplement to afferent neurocardiac signals, cue reactivity, and cognitive control

摘要 这是一份对现有R21，NIAAA R21 AA029604的行政补充申请，标题为 传入神经心脏信号，线索反应和认知控制。有意识地试图控制酒精 使用可以被环境中的酒精暗示所破坏，这些酒精暗示会引起自动注意和生理反应。 唤醒过程中断行为控制。我们之前发现， 神经调节，被称为“共振节奏呼吸”，可以改变大脑激活过程中被动观看， 酒精暗示目前的研究测量了大脑在主动认知过程中的反应， 酒精线索，并检查这种形式的神经调节是否可以用来减少线索反应， 增强真实的认知控制。本行政补充申请旨在支持我们的以下能力： 将R21 AA029604中的数据统一为通用定义，包括创建新的事件相关 潜在的（ERP）数据结构，并将其存款国家酒精滥用和酒精中毒研究所 数据存档（NIAAADA）。我们有能力投入所需的时间和精力来满足这一要求， 母项目将为科学界保存这一独特而宝贵的数据资源。公众 一种简单易行神经调节技术对减少酒精提示的健康意义 这一点非常重要，因为线索反应和渴望是过度饮酒和复发的关键因素。

Abstract This is an application for an Administrative Supplement to an existing R21, NIAAA R21 AA029604 titled “Afferent neurocardiac signals, cue reactivity, and cognitive control”. Conscious attempts to regulate alcohol use can be undermined by alcohol cues in the environment that elicit automatic attention and physiological arousal processes that interrupt behavioral control. We previously discovered that a behavioral form of neuromodulation, termed ‘resonance paced breathing,’ can alter brain activation during passive viewing of alcohol cues. The current study measures brain response during active cognitive processing in the context of alcohol cues and examines whether this form of neuromodulation can be used to reduce cue reactivity and enhance cognitive control in real time. This Administrative Supplement request is to support our ability to harmonize data from R21 AA029604 to a common definition, including the creation of new event-related potential (ERP) data structures, and deposit them in the National Institute on Alcohol Abuse and Alcoholism Data Archive (NIAAADA). Our ability to devote the needed time and effort to fulfill this requirement for the parent project will preserve this unique and valuable data resource for the scientific community. The public health significance of an accessible, brief, and easily trained neuromodulation technique to reduce alcohol cue salience is great, as cue reactivity and craving are key precipitants of excessive drinking and relapse.