Afferent neurocardiac signals, cue reactivity, and cognitive control

传入神经心脏信号、提示反应和认知控制

• 批准号: 10316413
• 负责人: Brandon L Alderman
• 金额: $ 21.63万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-20 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10316413
• 关键词: Affect; Alcohol consumption; Alcohol dependence; Alcohols; Anterior; Anxiety; Applications Grants; Area; Arousal; Attention; Back; Baroreflex; Behavior; Behavior Control; Behavior Therapy; Behavioral; Biofeedback; Brain; Brain region; Breathing; Cardiovascular system; Cognition; Cognitive; Complex; Conscious; Contralateral; Cues; Data; Desire for food; Development; Disease; Electrophysiology (science); Environment; Event; Event-Related Potentials; Exhibits; Feedback; Female; Frequencies; Functional Magnetic Resonance Imaging; Goals; Heart Rate; Heavy Drinking; Impairment; Individual Differences; Inferior; Interruption; Intervention; Knowledge; Lateral; Left; Link; Literature; Measures; Medial; Mediating; Mental Depression; Motivation; Neural Inhibition; Occipital lobe; Pattern; Peripheral; Peripheral Nervous System; Persons; Physiological; Pressoreceptors; Prevention; Process; Public Health; Public Health Applications Research; Reactive Inhibition; Relapse; Research Project Grants; Signal Transduction; Stimulus; Stream; Stress; System; Techniques; Testing; Time; Training; Training Technics; United States National Institutes of Health; Visceral; Visual; Visual Cortex; alcohol cue; alcohol response; attentional bias; base; behavior change; binge drinker; binge drinking; brief intervention; cognitive control; cognitive enhancement; craving; cue reactivity; dependence relapse; design; drinking; drinking behavior; experimental study; high risk population; intervention effect; millisecond; mobile application; neuroregulation; neurotransmission; novel; operation; programs; relating to nervous system; respiratory; response; secondary analysis; temporal measurement; visual control; young adult

This R21 application is in response to PA-20-196: NIH Exploratory/Developmental Research Grant Program, based on our discovery that a behavioral form of neuromodulation, termed ‘resonance paced breathing,’ alters brain activation during passive viewing of alcohol-related picture cues. Here we propose to determine the translational significance of this proof-of-concept finding by (1) measuring brain response during active cognitive processing in the context of alcohol cues and (2) testing the hypothesis that resonance breathing changes specific processing operations to reduce cue reactivity and support cognitive control. Multiple literatures support that these processes are mediated in part by a dynamic neurocardiac feedback loop termed the baroreflex, and that breathing paced at a resonance frequency of the cardiovascular system (~0.1Hz) modulates physiological responses to external stimuli. This knowledge has led to empirically supported long- term interventions for anxiety, depression, stress and other disorders (e.g., HRV biofeedback). Yet, the ability to use brief bouts of resonance breathing as a just-in-time intervention to alter attention to, and control over, appetitive cues is unknown. The public health significance of an accessible (via mobile app), brief, and easily trained technique to reduce alcohol cue salience is great, as cue reactivity and associated urges and craving are key precipitants of excessive drinking and relapse. We propose to test 100 binge drinking young adults (half female) in a within-subjects, repeated measures experiment to determine whether modulation of the afferent stream of the neurocardiac feedback loop through breathing paced at 0.1 Hz, compared to a control task, affects changes in neural cue reactivity and inhibitory control in the presence of salient alcohol cues. We will examine the effect of the 5-min intervention of 0.1 Hz resonance breathing task, and control task, on changes in the posterior contralateral N2 (N2pc) and P3b event-related potential (ERP) components as markers of attention allocation and motivational significance of attended stimuli using modified visual dot-probe and oddball tasks. Aim 2 will examine parallel effects on inhibitory control using the N2 component, elicited during a cued alcohol Go/NoGo paradigm. Primary hypotheses are that resonance breathing will diminish attention bias and motivational significance, and increase inhibitory control, when alcohol cues are encountered following the breathing task. Secondary analyses will explore the relation of individual differences in drinking patterns to intervention effects. If successful, this application will provide novel information about potential mechanisms through which resonance breathing is linked in a time-varying manner to neural systems that modulate cue reactivity. These preliminary data would provide premise for a larger scale study to examine the impact of resonance breathing in different high-risk populations of drinkers and its relation to drinking behavior change.

本R21申请是对PA-20-196：NIH探索/发展研究资助计划的回应， 基于我们的发现，一种被称为“共振节奏呼吸”的神经调节行为形式， 在被动观看酒精相关图片线索时的大脑激活。在这里，我们建议确定 这一概念验证发现的翻译意义是：（1）测量活动期间的大脑反应， 认知过程中的酒精线索和（2）测试的假设，共振呼吸 改变特定的处理操作，以减少线索反应和支持认知控制。多 文献支持这些过程部分是由动态神经心脏反馈回路介导的， 压力感受性反射，呼吸以心血管系统的共振频率（~0.1Hz）起搏 调节对外界刺激的生理反应这种认识导致了经验支持的长期- 用于焦虑、抑郁、压力和其他疾病的长期干预（例如，HRV生物反馈）。然而， 使用短暂的共振呼吸作为及时的干预，以改变对 食欲线索是未知的。一个可访问的（通过移动的应用程序），简短，轻松的公共卫生意义 训练有素的技术，以减少酒精线索的显着性是伟大的，因为线索反应和相关的冲动和渴望 是酗酒和复发的关键诱因我们打算测试100名酗酒的年轻人 (half女性）在受试者内，重复测量实验，以确定是否调制的 与对照组相比，通过0.1 Hz呼吸起搏的神经心脏反馈回路的传入流 任务，影响神经线索反应性和抑制控制的变化，在存在显着的酒精线索。我们 将检查0.1 Hz共振呼吸任务和控制任务的5分钟干预对 后对侧N2（N2 pc）和P3 b事件相关电位（ERP）成分的变化， 使用改进的视觉点探针的注意分配标记和注意刺激的动机意义 和古怪的任务目的2将使用N2成分检查对抑制控制的平行影响， 在一个暗示酒精的去/不去范例中。主要假设是共振呼吸会减少 注意力偏差和动机意义，并增加抑制控制，当酒精线索是 在呼吸任务之后遇到的。次要分析将探索个体差异的关系 饮酒模式对干预效果的影响。如果成功，该应用程序将提供有关以下方面的新信息 共振呼吸以随时间变化的方式与神经系统联系的潜在机制 调节线索反应性这些初步数据将为更大规模的研究提供前提， 共振呼吸对不同饮酒高危人群的影响及其与饮酒的关系 行为改变