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Malaria Parasite Receptors And Host Cell Ligands

Malaria Parasite Receptors And Host Cell Ligands
疟疾寄生虫受体和宿主细胞配体
批准号：
7299904
负责人：
Louis Miller
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/7299904
关键词：
MalariaParasiteReceptorsHostCell

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中文摘要
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英文摘要
Purpose: 1. To identify the receptors on malaria parasites for red cell invasion and on infected red cells for adhesion to endothelium and to placenta. 2. To identify the red cell ligands for each parasite receptor. 3. To identify the minimal domain in the variant antigen for binding to placenta. 4. Test a region on the variant antigen for inducing protection against P. falciparum in Aotus monkeys and for overcoming variation. 5. Identify P. falciparum proteins that induce antibodies to block infection. Accomplishments during the year: 1. Rhomboid, an intramembrane protease that cleaves parasite receptors, has been identified. 2. The sialic acid binding site has been identified on BAEBL, a parasite receptor.
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MALARIA VACCINE DEVELOPMENT UNIT (MVDU)
Malaria Parasite Ligands And Host Cell Receptors
Malaria Vaccines: BSAM-1/ALHYDROGEL + CPG 7909
Malaria Vaccines: AMA1-C1/ISA 720
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