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Malaria Parasite Ligands And Host Cell Receptors

Malaria Parasite Ligands And Host Cell Receptors
疟疾寄生虫配体和宿主细胞受体
批准号：
8946246
负责人：
Louis Miller
金额：
$92.26万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8946246
关键词：
BloodEpigenetic ProcessErythrocytesGene ExpressionGenesImmune responseKnock-outLigandsMalariaNamesParasitesPathway interactionsPhosphorylationPhosphotransferasesPlasmodium falciparumProteinsReceptor CellStagingStructureVaccinesWorkknockout geneparasite invasionreceptorsmall moleculesmall molecule librariesvaccine development

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英文摘要
Accomplishments during the year: 1. The immune response to AMA1 combined with RON2 has been studied. This work continues to expand our understanding of parasite invasion of red cells by identifying the receptors and ligands and determining the potential of these targets for vaccine development. 2. The knockout of a PfSET gene (named PfSETVS) leads to expression of all var genes, indicating that PfSETvs silences var genes. 3. We have identified some small molecules that block junction formation and invasion. 4. We are studying the pathway of phosphorylation by P. falciparum kinases. 5. We continue the study of the mechanism of red cell invasion by P. falciparum and P. vivax.
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MALARIA VACCINE DEVELOPMENT UNIT (MVDU)
Malaria Parasite Ligands And Host Cell Receptors
Malaria Vaccines: BSAM-1/ALHYDROGEL + CPG 7909
Malaria Vaccines: AMA1-C1/ISA 720
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