Immunology Physician Scientist Training Grant

描述（由申请人提供）：这是NIH T32机构培训补助金的竞争性更新申请，用于继续贝勒医学院的新培训计划，重点是培训医生作为免疫学学科的研究人员。启动资助6名学员，其中100%（3/3）的毕业学员获得终身教职，83%为女性，50%(3)为URM学员。学员是从贝勒ACGME/RRC批准的过敏、免疫学和风湿病学培训项目的大量优秀申请者中招募和选择的。申请每年继续提供4个博士后培训生职位。每年通过竞争选拔学员参加T32培训计划，接受2 - 3年的严格科学培训。18位终身教职教师被精心挑选为导师，他们在研究和教学方面表现卓越。学员参加研究生院课程和贝勒国立卫生研究院K30支持的临床研究医师课程，以获得基础科学和免疫学知识的坚实基础，开展临床研究的原则，以及研究的道德行为。受训者将在假设驱动的研究、手稿的准备和出版、在国家会议上的发言、拨款提案的准备、教学和指导技能以及学术生涯发展等方面得到全面指导。这些导师是从贝勒大学炎症生物学多学科中心、NIH/NIAID德克萨斯医学中心哮喘和过敏性疾病合作研究中心以及HHMI转化生物学和分子医学研究生项目的40多名教师中挑选出来的，该项目为研究人员提供了一个高度互动的关键质量，包括研究生、医学生、博士博士后、医学博士博士后和医学博士/博士博士后。导师提供细胞因子结构和功能、趋化因子生物学、粘附分子、信号转导和信号终止、基因激活、分子遗传学、组织重塑、细胞免疫学和免疫调节、小鼠炎症、感染和免疫模型、免疫介导疾病的病理生物学、流行病学有效工具设计和临床试验结果分析等方面的培训机会。该培训计划的目标是继续培养免疫学内科科学家，他们将成为未来的学术领袖。

DESCRIPTION (provided by applicant): This is a competitive renewal application for a NIH T32 institutional training grant for continuation of a new training program at Baylor College of Medicine focused on the training of physicians as investigators in the discipline of immunology. Initial funding has supported 6 trainees, of which 100% (3/3) of graduating trainees have taken tenure track academic positions, 83% are women, and 50% (3) of trainees are URM. Trainees are recruited and selected from a large pool of outstanding applicants to Baylor's ACGME/RRC approved training programs in allergy and immunology and in rheumatology. Continuation of four postdoctoral trainee positions annually is requested. Trainees are competitively selected for appointed to the T32 training program each year for two to three years of rigorous scientific training. Eighteen tenure track faculty have been carefully selected to serve as mentors, based on their excellence in research and teaching. Trainees enroll in graduate school courses and Baylor's NIH K30 supported physician scientist curriculum in clinical investigation to acquire a sound fund of knowledge in basic science and immunology, the principles of conducting clinical research, and the ethical conduct of research. Trainees will be comprehensively mentored in hypothesis driven research, preparation and publication of manuscripts, presentations at national meetings, preparation of grant proposals, skills for teaching and mentoring, and academic career development. The mentors are selected from over 40 faculty within Baylor's multidisciplinary Biology of Inflammation Center, NIH/NIAID Texas Medical Center Asthma and Allergic Diseases Cooperative Research Center, and HHMI Translational Biology and Molecular Medicine graduate program,, which provides a highly interactive critical mass of investigators with diverse trainees comprised of graduate students, medical students, PhD postdocs, MD postdocs, and MD/PhD postdocs. Mentors provide training opportunities in cytokine structure and function, chemokine biology, adhesion molecules, signal transduction and termination of signaling, gene activation, molecular genetics, tissue remodeling, cellular immunology and immunoregulation, murine models of inflammation, infection and immunity, the pathobiology of immune-mediated diseases, design of valid tools for epidemiology, and clinical trial outcome analysis. The goal of this training program is to continue to develop immunology physician-scientists who will serve as future academic leaders.