A Mature Brain Architecture Knowledge Management System

描述（由申请人提供）：拟议研究的长期目标是创建一个功能齐全的在线工作平台，用于获取有关构成大脑的生物回路的信息，并对健康和广泛的神经系统疾病（包括阿尔茨海默氏症、慢性疼痛、癫痫、多发性硬化症、帕金森氏症、中风和嗜睡症）中该回路的功能组织进行建模。这种方法在早期发展阶段的一个优势是，它补充了实验室中关于边缘系统回路的基本结构和化学组织的实验系统神经科学研究，边缘系统回路控制着基本的驱动力和情绪，以及学习和记忆。这里提出的神经信息学研究的基础是一个功能齐全、使用相对较多的网站，该网站始于2001年，被称为脑结构知识管理系统（b谷歌：BAMS）。它是目前唯一的在线系统，集成了四个层次组织的神经科学信息：灰质区域，构成区域的神经元细胞类型，区域和细胞类型之间的白质轴突连接，以及表达分子。公共卫生相关性：所有主要的神经系统疾病都在动物模型中进行了研究，包括大鼠。这项研究的目标是创建一个广泛使用的在线网站，以获取有关健康和疾病相关的大脑回路和系统的结构和化学信息，并为大脑的基本接线图建模，以及它如何在特定的神经系统疾病中受到影响，以特定的方式治疗。

DESCRIPTION (provided by applicant): The long-term goal of the proposed research is to create a fully functional online workbench for obtaining information about the biological circuits that make up the brain, and for modeling the functional organization of this circuitry in health and in a broad range of neurological diseases, including Alzheimer's, chronic pain, epilepsy, multiple sclerosis, Parkinson's, stroke, and narcolepsy. One strength of this approach in early stages of development is that it complements experimental systems neuroscience research in the lab on the fundamental structural and chemical organization of limbic system circuits that control the basic drives and emotions, along with learning and memory. The foundation of the neuroinformatics research proposed here is a functioning, relatively heavily used website begun in 2001 and called the Brain Architecture Knowledge Management System (Google: BAMS). It is currently the only online system that integrates neuroscience information at four levels of organization: gray matter Regions, neuronal Cell Types making up regions, white matter axonal Connections between regions and cell types, and expressed Molecules. PUBLIC HEALTH RELEVANCE: All of the major neurological diseases are studied in animal models including rat. The goal of the proposed research is to create a widely used online website for accessing information about the structure and chemistry of brain circuits and systems involved in health and disease, and for modeling the basic wiring diagram of the brain and how it is affected in specific neurological diseases, treated in specific ways.