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A Mature Brain Architecture Knowledge Management System

成熟的大脑架构知识管理系统

基本信息

批准号：
8287585
负责人：
LARRY W SWANSON
金额：
$ 31.75万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-08-01 至 2015-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8287585
关键词：
3-Dimensional Accounting Advisory Committees Affect Alzheimer&apos s Disease Animal Model Architecture Atlases Biological Biological Neural Networks Brain Brain Chemistry Chemicals Classification Clinical Collaborations Communities Complement Complex Data Data Set Data Sources Databases Development Disease model Educational workshop Emotions Epilepsy Feedback Foundations Funding Gene Expression Profile Goals Grant Graph Health Human Hypothalamic structure Information Resources Management Institute of Medicine (U.S.)Internet Learning Limbic System Link Literature Macaca Memory Metadata Methods Microscopy Modeling Motivation Multiple Sclerosis Mus Narcolepsy Nervous System Part Nervous system structure Neuraxis Neurologist Neurons Neurosciences Neurosciences Research Online Systems Ontology Parkinson Disease Pathway Analysis Pathway interactions Publishing Rattus Recommendation Reporting Research Spinal Cord Staging Stroke Structure Structure-Activity Relationship System Text Vertebral column Work base cell type chronic pain database design database structure design graduate student gray matter improved nervous system disorder neural circuit neuroinformatics programs prototype relating to nervous system web site white matter

项目摘要

DESCRIPTION (provided by applicant): The long-term goal of the proposed research is to create a fully functional online workbench for obtaining information about the biological circuits that make up the brain, and for modeling the functional organization of this circuitry in health and in a broad range of neurological diseases, including Alzheimer's, chronic pain, epilepsy, multiple sclerosis, Parkinson's, stroke, and narcolepsy. One strength of this approach in early stages of development is that it complements experimental systems neuroscience research in the lab on the fundamental structural and chemical organization of limbic system circuits that control the basic drives and emotions, along with learning and memory. The foundation of the neuroinformatics research proposed here is a functioning, relatively heavily used website begun in 2001 and called the Brain Architecture Knowledge Management System (Google: BAMS). It is currently the only online system that integrates neuroscience information at four levels of organization: gray matter Regions, neuronal Cell Types making up regions, white matter axonal Connections between regions and cell types, and expressed Molecules. PUBLIC HEALTH RELEVANCE: All of the major neurological diseases are studied in animal models including rat. The goal of the proposed research is to create a widely used online website for accessing information about the structure and chemistry of brain circuits and systems involved in health and disease, and for modeling the basic wiring diagram of the brain and how it is affected in specific neurological diseases, treated in specific ways.

描述（由申请人提供）：拟议研究的长期目标是创建一个功能齐全的在线工作台，用于获取有关构成大脑的生物回路的信息，并对健康和广泛的神经系统疾病中该回路的功能组织进行建模，包括阿尔茨海默病、慢性疼痛、癫痫、多发性硬化症、帕金森病、中风和发作性睡病。这种方法在开发早期阶段的优势之一是，它补充了实验室中关于控制基本驱动和情绪以及学习和记忆的边缘系统回路的基本结构和化学组织的实验系统神经科学研究。这里提出的神经信息学研究的基础是一个功能齐全、使用相对频繁的网站，该网站始于 2001 年，称为大脑架构知识管理系统（谷歌：BAMS）。它是目前唯一集成四个组织层次的神经科学信息的在线系统：灰质区域、构成区域的神经元细胞类型、区域和细胞类型之间的白质轴突连接以及表达分子。公共卫生相关性：所有主要神经系统疾病都是在包括大鼠在内的动物模型中进行研究。拟议研究的目标是创建一个广泛使用的在线网站，用于访问有关健康和疾病的大脑回路和系统的结构和化学信息，并对大脑的基本接线图进行建模，以及它在以特定方式治疗的特定神经系统疾病中如何受到影响。