MOLECULAR AND CELLULAR BIOCHEMISTRY CORE

中心和核心任务简介 哈佛消化疾病中心专注于消化道、肝脏和胰腺上皮细胞的细胞生物学和功能，以及上皮生物学如何在粘膜免疫和过敏、固有宿主防御、消化和吸收、胃肠道肿瘤的发展以及Gl道的许多其他功能中表现出来。 该中心旨在通过提供技术资源促进该领域的多学科研究。核心服务、科学专业知识和重要的交汇点，在哈佛附属医院、哈佛医学院和朗伍德医疗区邻近的研究机构的独立调查人员之间培养密切的科学和知识关系。我们的目标也是招募新的和现有的研究人员进入胃肠道生物学领域。 我们的首要使命是在与消化疾病相关的领域促进更好的基础科学和转化科学：“连接人们，创造机会，扩大资源”。 四个服务核心和一个管理核心提供共享的智力和科学资源，以加强这一努力和我们研究基地的生产率(见图1-核心)。 每个核心为人类发展中心提供以下一般资源：核心服务、材料和试剂 仪器和设备-专业知识、规程和培训核心开发研究核心D为HDDC成员提供了蛋白质和脂肪生物化学方面所需的主要技术以及蛋白质组学方面的一整套高级服务。

Introduction to Center and Core Missions The Harvard Digestive Disease Center is focused on the cell biology and function of epithelial cells of the alimentary tract, liver, and pancreas; and how epithelial biology manifests itself in mucosal immunity and allergy, innate host defense, digestion and absorption, the development of gastrointestinal neoplasia, and the many other functions of the Gl tract. The Center aims to facilitate multidisciplinary research in this field by providing technical resources. Core services, scientific expertise, and an important meeting point to foster close scientific and intellectual relationships among independent investigators in Harvard-affiliated hospitals, the Harvard Medical School and adjacent research institutions in the Longwood Medical Area. We also aim to recruit new and established investigators into the fields of gastrointestinal biology. Our overarching mission is to foster better basic and translational science in fields related to digestive diseases by: "connecting people, 'creating opportunity, and 'extending resources. Shared intellectual and scientific resources to enhance this effort and the productivity of our research base are provided by four service Cores and an Administrative Core (see Figure 1-CoreD). Each Core provides the following general resources to the HDDC: ¿ Core Services ¿ Materials and Reagents ¿ Instrumentation and Equipment -Expertise, Protocols, and Training ¿ Core-development research Core D provided HDDC members with needed work-horse technologies in protein and lipid biochemistry and a full array of advanced services in Proteomics.