Cancer Center Support Grant (CCSG)

描述（由申请人提供）：圣裘德儿童研究医院的使命是通过研究和治疗为患有灾难性疾病的儿童找到治愈方法。在其44年的历史中，医院的资源一直集中在儿科癌症上，癌症中心得到CCSG的支持已有29年。通过美国黎巴嫩叙利亚人联合慈善会的支持，病人无论是否有支付能力都被接受，该慈善会是一个单独的公司，其唯一目的是筹集资金支持圣裘德儿童研究医院。通过ALSAC对医院的公众支持为我们的癌症中心提供了坚实的基础，在此基础上，可以充分利用校外资助的研究和CCSG的支持。在本申请中，描述了六个多学科研究项目。分子肿瘤学（MO）和信号转导（ST）计划专注于基础，发现为导向的研究。实体肿瘤（DTSM），血液肿瘤（HM），神经生物学和脑肿瘤（NBT）以及癌症预防和控制（CPC）计划的开发治疗强调实验室或人口科学向临床应用的转化。后一个项目是这一应用的新项目，代表了长期致力于对我们的患者人群进行长期随访、最近致力于人口科学以及成功招募世界级科学家领导这一领域工作的成果。癌症中心的139名成员的研究得到了12个共享资源和优秀的临床研究基础设施的支持。在上一个资助期间，任命了一位新的癌症中心主任，我们癌症中心的整体结构及其领导层通过几次组织变革得到了加强，包括将支持广泛临床试验工作的基础设施纳入癌症中心的管理范围。几个项目负责人的变化和三个新的优秀系主任（免疫学，化学生物学和流行病学/癌症控制）在最后一个资助期的成功招聘显着增强了我们的癌症中心计划所做的多学科科学。圣裘德癌症中心的研究人员在资助期间发表了2000多篇癌症相关的出版物，其中20%是项目内的相互作用，15%是项目间的相互作用。目前，圣裘德癌症研究的校外支持每年超过5000万美元，其中3100万美元来自NCI/HHMI。圣裘德儿童研究医院最近经历了一个强有力的战略规划过程，并作出了坚定和长期的承诺，继续专注于癌症研究。

DESCRIPTION (provided by applicant): The mission of St. Jude Children's Research Hospital is to find cures for children with catastrophic illnesses through research and treatment. The resources of the hospital have been focused on pediatric cancer throughout its 44 year history and the Cancer Center has been supported by a CCSG for 29 years. Through the support of the American Lebanese Syrian Associated Charities (ALSAC), a separate corporation whose only purpose is to raise money in support of St. Jude Children's Research Hospital, patients are accepted without regard to ability to pay. Public support of the hospital through ALSAC provides a strong foundation for our Cancer Center upon which extramurally funded research and CCSG support can be leveraged to their fullest potential. In the current application, six multidisciplinary research programs are described. The Molecular Oncology (MO) and Signal Transduction (ST) Programs focus on basic, discovery-oriented research. The Developmental Therapeutics for Solid Malignancies (DTSM), Hematologic Malignancies (HM), Neurobiology and Brain Tumor (NBT), and Cancer Prevention and Control (CPC) Programs emphasize the translation of laboratory or population science to clinical application. The latter program is new to this application and represents the culmination of a long-standing commitment to long-term follow-up of our patient population, a recent commitment to population sciences, and successful recruitment of a world-class scientist to lead efforts in this area. Research by the 139 members of the Cancer Center is supported by 12 Shared Resources and an outstanding clinical research infrastructure. During the previous funding period, a new Cancer Center Director was appointed and the overall structure of our Cancer Center and its leadership were enhanced by several organizational changes, including bringing the infrastructure supporting the expansive clinical trials efforts administratively under the Cancer Center's authority. Several Program leader changes and the successful recruitment of three new outstanding Department Chairs (Immunology, Chemical Biology, and Epidemiology/Cancer Control) during the last funding period significantly enhance the multidisciplinary science done by our Cancer Center Programs. St. Jude Cancer Center investigators had over 2000 cancer-related publications during the funding period, 20% of which represented intraprogrammatic interactions and 15% of which were inter-programmatic. Extramural support for cancer research done at St. Jude is currently over $50 million per year, $31 million of which is from the NCI/HHMI. St. Jude Children's Research Hospital recently went through a vigorous Strategic Planning process and made a strong and long-term commitment to remain focused on cancer research.