Southwest Environmental Health Sciences Center

西南环境健康科学中心

• 批准号: 8299222
• 负责人: Serrine S Lau
• 金额: $ 15.15万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8299222
• 关键词: Adverse effects; Aging; Area; Arizona; Basic Science; Bioinformatics; Biological Markers; Cancer Center; Cells; Chemicals; Child; Chromatin; Clinical; Collaborations; Community Health Education; Community Outreach; Complement; Core Facility; Detection; Development; Discipline of Nursing; Disease; Education; Educational workshop; Environmental Exposure; Environmental Health; Exposure to; Faculty; Foundations; Genomics; Goals; Government Agencies; Health; Health Professional; Health Sciences; Heart; Hispanics; Image; Institutes; Interdisciplinary Study; Lung; Lung diseases; Mediating; Medicine; Minority; Native Americans; Newsletter; Pharmacy facility; Pilot Projects; Play; Predisposition; Prevention; Private Sector; Proteins; Proteomics; Public Health; Research; Research Activity; Research Personnel; Respiratory Center; Role; Science; Services; Sister; Students; Synthesis Chemistry; System; Technology; Tissues; Toxic effect; Toxicogenomics; Toxicology; Universities; adduct; base; cellular imaging; college; design; environmental agent; environmental chemical; health organization; health science research; human disease; innovation; instrumentation; interest; member; novel; prevent; programs

The theme that unites the research activities of the Southwest Environmental Health Sciences Center (SWEHSC) is the need to understand the mechanisms by which exposures to environmental agents contribute to human disease. Identifying factors that contribute to human diseases that arise as a consequence of environmental exposures is a prerequisite for the development of strategies designed to minimize both the environmental exposure, and the adverse effects of such exposures. The SWEHSC is a dynamic organization that promotes collaborative, interdisciplinary research, with an emphasis on the detection and prevention of environmentally-mediated diseases. Members of the SWEHSC are organized into three Research Cores (RC) with overlapping spheres of interest; Mechanisms of Environmental Chemical Toxicity (RC1), Pulmonary Toxicology and Lung Disease (RC2), and Chemical-Chromatin Interactions (RC3). The Research Cores provide the scientific foundation that provides the basis for strategies designed to treat or prevent environmental diseases. The research efforts of SWEHSC are complemented by five Facility Cores (FC); Cellular Imaging, Genomics, Proteomics, Synthetic Chemistry, and Bioinformatics. The Facility Cores offer state-of-the-art instrumentation and expertise to assist investigators in developing and utilizing cutting-edge technologies. The Administrative Core provides enrichment programs, including seminars, workshops, an annual Science Fair, newsletters, and supports the activities of the Internal and External Advisory Boards. The SWEHSC is also actively involved in promoting innovative research through the Pilot Project Program, and in the recruitment of new investigators. The Community Outreach and Education Program (COEP) offers environmental health science and toxicology based educational programs that are geared to students (K-12), health professionals, and the public. Through the COEP, the SWEHSC provides service to health organizations, government agencies, and the private sector. Three major inter-dependent goals will provide the focus for the next 5 years of support. The SWEHSC will (1) Facilitate the utilization and integration of" global" systems-centered toxicological approaches (proteomics, toxicogenomics, SNP's, cell and tissue imaging) to basic environmental health science research questions. (2) Facilitate the extension of basic research discoveries into the clinical and public health arenas. SWEHSC faculty, in collaboration with faculty in the Colleges of Public Health, Medicine, Pharmacy, and Nursing, will focus in the general area of novel biomarkers (SNP's, proteins, protein adducts, etc) of susceptibility, particularly within minority populations (Hispanic, Native American). Emerging border health initiatives will play an integral role in developing these new areas of emphasis. (3) Initiate and expand collaborations with sister Centers of Excellence on the University of Arizona Health Sciences Center campus (e.g., Arizona Respiratory Center, The University of Arizona Sarver Heart Center, Arizona Cancer Center, Arizona Center on Aging, Steele Memorial Children's Research Center and the BIOS Institute). This last goal is synergistic with the objective of extending basic research discoveries into the clinical and public health arenas.

团结西南环境健康科学中心（SWEHSC）的研究活动的主题是需要了解暴露于环境因子导致人类疾病的机制。 查明因环境接触而引起的人类疾病的促成因素是制定旨在尽量减少环境接触及其不利影响的战略的先决条件。SWEHSC是一个充满活力的组织，促进合作，跨学科研究，重点是检测和预防环境介导的疾病。 SWEHSC的成员被组织成三个研究核心（RC），具有重叠的兴趣领域;环境化学毒性机制（RC 1），肺毒理学和肺部疾病（RC 2）和化学染色质相互作用（RC 3）。研究核心为旨在治疗或预防环境疾病的战略提供了科学基础。SWEHSC的研究工作由五个设施核心（FC）补充：细胞成像，基因组学，蛋白质组学，合成化学和生物信息学。 设施核心提供最先进的仪器和专业知识，以协助调查人员开发和利用尖端技术。行政核心提供丰富的方案，包括研讨会，讲习班，年度科学博览会，通讯，并支持内部和外部咨询委员会的活动。SWEHSC还通过试点项目计划积极参与促进创新研究，并招募新的研究人员。社区外展和教育计划（COEP）提供面向学生（K-12），卫生专业人员和公众的环境健康科学和毒理学教育计划。SWEHSC通过COEP向卫生组织、政府机构和私营部门提供服务。三个相互依存的主要目标将为今后五年的支持提供重点。SWEHSC将（1）促进利用和整合以“全球”系统为中心的毒理学方法（蛋白质组学，毒理基因组学，SNP，细胞和组织成像），以解决基本的环境健康科学研究问题。 (2)促进将基础研究发现扩展到临床和公共卫生领域。SWEHSC教师与公共卫生，医学，药学和护理学院的教师合作，将专注于易感性的新生物标志物（SNP，蛋白质，蛋白质加合物等）的一般领域，特别是在少数民族人群中（西班牙裔，美洲原住民）。 新出现的边境卫生倡议将在发展这些新的重点领域方面发挥不可或缺的作用。 (3)发起并扩大与亚利桑那大学健康科学中心校园的姐妹卓越中心的合作（例如，亚利桑那呼吸中心、亚利桑那大学萨弗心脏中心、亚利桑那癌症中心、亚利桑那老龄化中心、斯蒂尔纪念儿童研究中心和BIOS研究所）。最后一个目标与将基础研究发现扩展到临床和公共卫生领域的目标具有协同作用。