Core C: Data Management & Statistics Core

核心C：数据管理

• 批准号: 9325390
• 负责人: GRACIELA GONZALEZ HERNANDEZ
• 金额: $ 25.81万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9325390
• 关键词: Accountability; Address; Advisory Committees; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s Disease Core Center; Applications Grants; Appointment; Arizona; Basic Science; Behavioral; Brain imaging; Clinical; Clinical Research; Cognitive; Collaborations; Computer Analysis; Computer software; Data; Data Analyses; Data Set; Databases; Detection; Development; Disease; Early Diagnosis; Enrollment; Ensure; Evaluation; Experimental Designs; Genetic; Geography; Goals; Grant; Heart; Image; International; Intervention Studies; Investigational Therapies; Lead; Link; Manuscripts; Mathematics; Mentors; Methods; Monitor; Neuropsychology; Online Systems; Participant; Performance; Pilot Projects; Preparation; Prevention therapy; Program Development; Publications; Published Comment; Recommendation; Reporting; Research; Research Personnel; Research Support; Resources; Secure; Services; Site; Standardization; Statistical Data Interpretation; Statistical Methods; Students; Supervision; System; Systems Analysis; Techniques; Testing; Therapeutic Studies; Time; Training and Education; Translational Research; Update; Work; aging brain; analytical method; bench to bedside; catalyst; data management; data mining; data sharing; design; genome wide association study; genomic data; improved; mathematical analysis; method development; neuroimaging; neuropathology; novel; performance site; programs; response; statistical service; statistics; transmission process; web app; working group

PROJECT SUMMARY/ABSTRACT The Data Management and Statistics Core (DMSC) provides comprehensive data management, high quality statistical, experimental design support and neuroimaging processing/analysis assistance for the Arizona ADC. The core assures and maintains data accuracy and accessibility for the center's investigators, facilitates the sharing of data with collaborators, and guarantees full compliance with the National Alzheimer's Coordinating Center (NACC). The DMSC also supports new research, acts as catalyst to prompt collaborations inside and outside Arizona, and actively engages in the development, testing, and implementation of novel analytic methods and software. In response to the constructive and insightful prior review of the DMSC from 2011, we reorganized DMSC and are pleased to have Dr. Kewei Chen join Dr. Graciela Gonzalez to co-chair the DMSC. Dr. Chen will lead the statistics efforts, while Dr. Gonzalez will continue to lead all data management efforts. With expertise in statistics, database, neuroimaging, and novel statistical methods development, the DMSC is poised to advance basic, clinical, and intervention research in the early detection, tracking, and prevention of AD. We propose four aims to facilitate high impact bench-to-bedside, translational research: (1) To provide comprehensive data management for acquisition, organization, use, and sharing of data from participants enrolled and followed, (2) To provide statistical, experimental design, and neuroimaging analysis support for new and ongoing projects, (3) To develop, test, and implement new statistical, image analytic, and data management methods and applications to advance the goals of the Arizona ADC, and (4) To actively facilitate research collaborations both inside and outside Arizona to advance the goals and objectives of our center. We will be replacing our old MSAccess database with a new centralized, integrated database that will link imaging and genomic data to the UDS data. It will also allow direct entry from each ADC site via a secure web application, and include a web-based querying system for researchers across our geographically distributed center. Statistical assistance will be provided by the newly formed Statistical Analysis Workgroup consisting of Drs. Chen, Wilson, Alexander, Langbaum and Dueck. Finally, we establish metrics for the data program's development and routine provision of ADCC performance to help the Executive Committee monitor performance and progress and modify its activities accordingly.

项目概要/摘要 数据管理和统计核心 (DMSC) 提供全面的数据管理、高质量 为亚利桑那州 ADC 提供统计、实验设计支持和神经影像处理/分析帮助。 该核心确保并维护中心调查人员的数据准确性和可访问性，促进 与合作者共享数据，并保证完全遵守国家阿尔茨海默病协调中心 中心（NACC）。 DMSC 还支持新的研究，充当促进内部和外部合作的催化剂 在亚利桑那州郊外，积极参与新颖分析的开发、测试和实施 方法和软件。为了回应 2011 年以来对 DMSC 进行的建设性和富有洞察力的先前审查，我们 重组了 DMSC，并很高兴陈科伟博士与 Graciela Gonzalez 博士一起担任 DMSC 联合主席。 陈博士将领导统计工作，而冈萨雷斯博士将继续领导所有数据管理工作。 凭借统计学、数据库、神经影像学和新颖统计方法开发方面的专业知识，DMSC 准备推进早期检测、跟踪和预防方面的基础、临床和干预研究 广告。我们提出了四个目标来促进高影响力的从实验室到临床的转化研究：(1) 提供 全面的数据管理，用于获取、组织、使用和共享参与者的数据 注册并跟踪，（2）为以下患者提供统计、实验设计和神经影像分析支持 新的和正在进行的项目，(3) 开发、测试和实施新的统计、图像分析和数据 管理方法和应用程序，以推进亚利桑那州 ADC 的目标，以及 (4) 积极促进 亚利桑那州内外的研究合作，以推进我们中心的目标和目标。我们 将用一个新的集中式集成数据库取代我们旧的 MSAccess 数据库，该数据库将链接成像 和基因组数据到 UDS 数据。它还允许通过安全网络从每个 ADC 站点直接访问 应用程序，并包括一个基于网络的查询系统，供我们地理分布的研究人员使用 中心。新成立的统计分析工作组将提供统计协助，该工作组包括 博士。陈、威尔逊、亚历山大、朗鲍姆和杜克。最后，我们为数据程序建立指标 ADCC 绩效的开发和日常提供，以帮助执行委员会监控 绩效和进展并相应地修改其活动。