Core C: Data Management & Statistics Core

项目摘要/摘要 数据管理和统计核心(DMSc)提供全面、高质量的数据管理 为亚利桑那州ADC提供统计、实验设计支持和神经成像处理/分析协助。 该核心确保和维护中心调查人员的数据准确性和可访问性，促进 与合作者共享数据，并保证完全遵守国家阿尔茨海默氏症协调 中心(NACC)。DMSc还支持新的研究，充当催化剂，促进内部和 在亚利桑那州以外，并积极参与开发、测试和实施新的分析 方法和软件。为回应自2011年以来对DMSc进行的建设性和富有洞察力的先前审查，我们 重组了DMSc，并很高兴邀请陈克伟博士与Graciela Gonzalez博士一起担任DMSc的联合主席。 陈博士将领导统计工作，而冈萨雷斯博士将继续领导所有数据管理工作。 DMSc拥有统计学、数据库、神经成像和新的统计方法开发方面的专业知识， 准备推进基础、临床和干预研究，以早期发现、跟踪和预防 广告。我们提出了四个目标，以促进高影响力的工作台到床边，翻译研究：(1)提供 全面的数据管理，用于获取、组织、使用和共享参与者的数据 注册并跟踪，(2)为以下项目提供统计、实验设计和神经成像分析支持 新的和正在进行的项目，(3)开发、测试和实施新的统计、图像分析和数据 管理方法和应用程序，以推进亚利桑那州ADC的目标，以及(4)积极促进 亚利桑那州内外的研究合作，以推进我们中心的目标和目标。我们 将用新的集中式集成数据库取代我们的旧MSAccess数据库，该数据库将链接映像 和基因组数据到UDS数据。它还将允许从每个ADC站点通过安全的网络直接进入 应用程序，并包括一个基于Web的查询系统，供我们地理上分散的研究人员使用 中间。统计援助将由新成立的统计分析工作组提供，工作组包括 陈博士、威尔逊博士、亚历山大博士、朗鲍姆博士和杜克博士。最后，我们为数据程序的 制定和例行提供ADCC绩效，以帮助执行委员会进行监测 执行情况和进展，并相应地修改其活动。

PROJECT SUMMARY/ABSTRACT The Data Management and Statistics Core (DMSC) provides comprehensive data management, high quality statistical, experimental design support and neuroimaging processing/analysis assistance for the Arizona ADC. The core assures and maintains data accuracy and accessibility for the center's investigators, facilitates the sharing of data with collaborators, and guarantees full compliance with the National Alzheimer's Coordinating Center (NACC). The DMSC also supports new research, acts as catalyst to prompt collaborations inside and outside Arizona, and actively engages in the development, testing, and implementation of novel analytic methods and software. In response to the constructive and insightful prior review of the DMSC from 2011, we reorganized DMSC and are pleased to have Dr. Kewei Chen join Dr. Graciela Gonzalez to co-chair the DMSC. Dr. Chen will lead the statistics efforts, while Dr. Gonzalez will continue to lead all data management efforts. With expertise in statistics, database, neuroimaging, and novel statistical methods development, the DMSC is poised to advance basic, clinical, and intervention research in the early detection, tracking, and prevention of AD. We propose four aims to facilitate high impact bench-to-bedside, translational research: (1) To provide comprehensive data management for acquisition, organization, use, and sharing of data from participants enrolled and followed, (2) To provide statistical, experimental design, and neuroimaging analysis support for new and ongoing projects, (3) To develop, test, and implement new statistical, image analytic, and data management methods and applications to advance the goals of the Arizona ADC, and (4) To actively facilitate research collaborations both inside and outside Arizona to advance the goals and objectives of our center. We will be replacing our old MSAccess database with a new centralized, integrated database that will link imaging and genomic data to the UDS data. It will also allow direct entry from each ADC site via a secure web application, and include a web-based querying system for researchers across our geographically distributed center. Statistical assistance will be provided by the newly formed Statistical Analysis Workgroup consisting of Drs. Chen, Wilson, Alexander, Langbaum and Dueck. Finally, we establish metrics for the data program's development and routine provision of ADCC performance to help the Executive Committee monitor performance and progress and modify its activities accordingly.