课题基金 / 基金详情

Pregnancy Malaria Vaccine development

Pregnancy Malaria Vaccine development
妊娠期疟疾疫苗开发
批准号：
9566748
负责人：
Patrick Duffy
金额：
$30.39万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/9566748
关键词：
AnemiaAnimalsAntibodiesAntigensBindingChondroitin Sulfate AGoalsImmunityImmunizeInfant MortalityLow Birth Weight InfantMalariaMalaria VaccinesMediatingModelingMolecularParasitesPathogenesisPlacentaPre-EclampsiaPregnancyPregnancy lossProteinsPublic HealthTestingWomanexperimental studyinhibiting antibodynonhuman primatereceptor bindingvaccine development

项目摘要

项目成果

Patrick Duffy的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
Pregnancy malaria (PM) is a major public health problem associated with severe maternal anemia, preeclampsia, pregnancy loss, low birthweight delivery and infant mortality. PM is caused by sequestration in the placenta of parasites that bind the receptor chondroitin sulfate A (CSA). Previous ex vivo experiments have shown that parasite binding to CSA can be inhibited by antibodies from multigravida women who acquired specific immunity to CSA-binding parasites, or by antibodies from animals immunized with antigens that mediate parasite binding to CSA.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Malaria Surveillance and Research Studies in Liberia and Guinea-Conakry
Malaria Transmission Blocking Vaccine Discovery
Malaria Pathogenesis in young children and vaccine discovery
Gametocyte Carriage Rate and Transmission Blocking Vaccine Assay Development
海外基金