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中文摘要
翻译
我们与NICHD发育和分子免疫学实验室的John Robbins博士和Rachel Schneerson博士合作,开发了一种由Pfs25-Pfs25结合物组成的候选结合疫苗。该结合疫苗诱导的免疫血清具有阻断蚊体内寄生虫生长的能力。向FDA提交了一份研究性新药申请,打算进行一期试验,以测试其安全性、免疫原性和人体外传播阻断活性。为了回应食品和药物管理局的评论,进行了更多的动物研究,以评估动物的安全性。
英文摘要
In collaboration with Drs. John Robbins and Rachel Schneerson at the Laboratory of Developmental and Molecular Immunology of the NICHD, we have developed a candidate conjugate vaccine that consists of Pfs25-Pfs25 conjugates. The immune sera induced by the conjugate vaccine displayed ability to block parasite development in mosquitoes. An Investigational New Drug Application was filed with FDA, intending a Phase 1 trial to test the safety, immunogenicity, and ex-vivo transmission blocking activity in humans. In response to FDAs comment, additional animal studies were conducted to evaluate the safety in animals.
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Malaria Surveillance and Research Studies in Liberia and Guinea-Conakry
Malaria Transmission Blocking Vaccine Discovery
Malaria Pathogenesis in young children and vaccine discovery
Malaria Vaccine: Pfs25-rEPA
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海外基金
Aluminum/CFRP 混合管界面分层对渐进折叠机制影响研究
  • 批准号:
    ZCLQN26E0501
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2026
  • 负责人:
    沈勇
  • 依托单位: