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Malaria Vaccine: CSP-rEPA

Malaria Vaccine: CSP-rEPA
疟疾疫苗：CSP-rEPA
批准号：
8336227
负责人：
Patrick Duffy
金额：
$167.29万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8336227
关键词：
AdjuvantAgonistAnimal ModelAnimalsAntibody FormationAntigensC-terminalCTL assayCarrier ProteinsCellsDrug FormulationsErythrocytesEscherichia coliImmuneLengthLongevityMalariaMalaria VaccinesMeasuresMediatingN-terminalParasitesPeptide Signal SequencesPlasmodium falciparumPolysaccharidesProcessProteinsRecombinant ProteinsRecombinantsRecoveryRodentRodent ModelSignal TransductionStagingT cell responseTLR4 geneVaccinesbasecircumsporozoite proteincross reacting material 197designenzyme linked immunospot assayimmunogenicitynovelresponse

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中文摘要
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英文摘要
rCSP in various lengths were expressed in P. pastoris and E. coli, and processes for scaled recovery were developed. Processes were developed to chemically conjugate the rCSPs to recombinant EPA and CRM197, the carrier proteins with demonstrated capacity of immune enhancement for polysaccharide antigens. B- and T-cell responses, induced by the conjugates in several formulations were evaluated in rodent models. Whereas conjugation significantly increase the antibody responses to the rCSP, a novel adjuvant containing TLR4 agonist significantly increase cellular response in rodents.
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会议论文
Malaria Surveillance and Research Studies in Liberia and Guinea-Conakry
Malaria Transmission Blocking Vaccine Discovery
Malaria Pathogenesis in young children and vaccine discovery
Malaria Vaccine: Pfs25-rEPA
国内基金
海外基金
Agonist-GPR119-Gs复合物的结构生物学研究
  • 批准号：
    32000851
  • 项目类别：
    青年科学基金项目
  • 资助金额：
    24.0万元
  • 批准年份：
    2020
  • 负责人：
    乔安娜
  • 依托单位：
    天津大学