Emory Integrated Proteomics Core

Emory集成蛋白质组学共享资源 项目摘要/摘要 Emory集成蛋白质组学共享资源的使命是提供蛋白质 使用尖端质谱仪(MS)支持Winship癌症研究所的分析服务。主 蛋白质组学SR的技术平台是液-质联用(LC-MS)。 MS/MS)用于蛋白质及其翻译后修饰的高灵敏鉴定和定量 (PTMS)。蛋白质组学SR是Winship调查人员的关键技术资源，并支持了广泛的 与癌细胞生物学、遗传学、表观遗传学和新疗法相关的一系列癌症项目。初级阶段 蛋白质组学SR的目标是：(1)为这两个发现提供最先进的质谱学 和有针对性的蛋白质组学应用，(2)为蛋白质组学相关的咨询、专家培训和支持 研究项目，以及(3)提供促进多学科协作的基础设施和资源 Winship调查人员的研究和创新。总而言之，这些目标将导致 通过实验设计优化和优化为Winship研究人员提供蛋白质组数据的质量 恰当的解释。提供的质谱学技术对Winship研究人员和Key 这些蛋白质组学研究的结果是Winship努力改进预防、检测、 以及人类癌症的治疗。

EMORY INTEGRATED PROTEOMICS SHARED RESOURCE PROJECT SUMMARY / ABSTRACT The mission of the Emory Integrated Proteomics Shared Resources (Proteomics SR) is to provide protein analytical services using cutting-edge mass spectrometry (MS) in support of Winship Cancer Institute. The main technology platform of Proteomics SR is liquid chromatography coupled with tandem mass spectrometry (LC- MS/MS) for highly sensitive identification and quantification of proteins and their post-translational modifications (PTMs). Proteomics SR is a critical technological resource for Winship investigators and has supported a broad range of cancer projects related to cancer cell biology, genetics, epigenetics, and novel therapeutics. The primary aims of the of Proteomics SR are to provide: (1) access to state-of-the-art mass spectrometry for both discovery and targeted proteomic applications, (2) provide consultation, expert training, and support for proteomics-related research projects, and (3) provide infrastructure and resources that advance collaborative multidisciplinary research and innovation among Winship investigators. Collectively, these aims will lead to an increase in the quality of proteomics data available to Winship investigators through experimental design optimization and proper interpretation. The mass spectrometry technologies provided are vital to Winship researchers and key findings from these proteomic studies are fundamental to Winship's efforts to improve the prevention, detection, and treatment of human cancers.