12/24 Healthy Brain and Child Development National Consortium

项目概要/摘要 神经发育过程是由基因和环境之间的动态相互作用决定的。 生命早期的适应不良经历会改变发育轨迹，导致有害和持久的 发育后遗症。产前和产后危害包括母体物质暴露、有毒物质 怀孕和早年接触、孕产妇健康状况、父母精神病理学、虐待、 结构性种族主义和过度压力。阐明各种环境危害如何影响儿童 为实现发展，必须制定前 10 年发展轨迹的规范模板 生活的建立是基于足够大且人口多样化的美国人口样本。至 为了实现这一目标，健康大脑和儿童发展国家联盟 (HBCD-NC) 已经成立 部署一套协调、优化和创新的神经影像（MRI、EEG）措施作为补充 通过一系列广泛的行为、生理和心理工具以及生物样本来了解 在全国 24 个地点招募的 7,500 名母亲和婴儿样本中的神经发育轨迹 美国（US）。 HBCD-NC 将在 HBCD-NC 的指导下开展共同研究方案 NC 行政核心 (HCAC) 将收集和分发全面且精心策划的研究 在 HBCD-NC 数据协调中心的指导下向整个科学界提供数据集 （HDCC）。 HBCD-NC 的总体目标是创建一个全面、协调和高水平的 维度数据集将描述美国儿童的典型神经发育轨迹，并且将 评估生物和环境暴露如何影响这些轨迹。将特别强调的是 致力于了解产前和产后接触阿片类药物、大麻、酒精、烟草的影响 和/或其他物质。为了实现这些广泛的目标，登记的女性样本将包括：1) 代表美国人口的种族、民族和社会经济多样化群体； 2） 使用目标物质（阿片类药物、大麻、酒精、烟草）的孕妇；和 3) 人口统计和行为相似的女性，在怀孕期间没有使用药物，以实现有效的因果关系 推论。此外，HBCD-NC 将确定关键的发展窗口，在此期间有害和 保护环境对以后的神经发育结果影响最大。大型、多 本研究首次产生的模态、纵向和可概括的数据集将提供 使用最先进的方法对儿童发展提出新颖的见解。 HBCD-NC 研究将告知公众 改善全国儿童健康和发展的政策。

PROJECT SUMMARY/ABSTRACT Neurodevelopmental processes are shaped by dynamic interactions between genes and environments. Maladaptive experiences early in life can alter developmental trajectories, leading to harmful and enduring developmental sequelae. Pre- and postnatal hazards include maternal substance exposure, toxicant exposures in pregnancy and early life, maternal health conditions, parental psychopathology, maltreatment, structural racism, and excessive stress. To elucidate how various environmental hazards impact child development, it is imperative that a normative template of developmental trajectories over the first 10 years of life be established based on a sufficiently large and demographically diverse sample of the US population. To accomplish this, the Healthy Brain and Child Development National Consortium (HBCD-NC) has been formed to deploy a harmonized, optimized, and innovative set of neuroimaging (MRI, EEG) measures complemented by an extensive battery of behavioral, physiological, and psychological tools, and biospecimens to understand neurodevelopmental trajectories in a sample of 7,500 mothers and infants enrolled at 24 sites across the United States (US). The HBCD-NC will carry out a common research protocol under direction of the HBCD- NC Administrative Core (HCAC) and will assemble and distribute a comprehensive and well-curated research dataset to the scientific community at large under the direction of the HBCD-NC Data Coordinating Center (HDCC). The overarching goal of the HBCD-NC is to create a comprehensive, harmonized, and high- dimensional dataset that will characterize typical neurodevelopmental trajectories in US children and that will assess how biological and environmental exposures affect those trajectories. A special emphasis will be placed on understanding the impact of pre- and postnatal exposure to opioids, marijuana, alcohol, tobacco and/or other substances. To address these broad objectives, the sample of women enrolled will include: 1) a racially, ethnically, and socioeconomically diverse cohort that is representative of the US population; 2) pregnant woman with use of targeted substances (opioids, marijuana, alcohol, tobacco); and 3) demographically and behaviorally similar women without substance use in pregnancy to enable valid causal inferences. In addition, the HBCD-NC will identify key developmental windows during which both harmful and protective environments have the most influence on later neurodevelopmental outcomes. The large, multi- modal, longitudinal, and generalizable dataset that will be produced for the first time by this study will provide novel insights into child development using state-of-the-art methods. The HBCD-NC study will inform public policy to improve the health and development of children across the nation.