12/24 The Healthy Brain and Child Development National Consortium

12/24 健康大脑和儿童发展国家联盟

• 批准号: 10747646
• 负责人: Alice M Graham
• 金额: $ 21.09万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10747646
• 关键词: Administrative Supplement; Alcohols; Anxiety; Behavior; Behavioral; Biological; Biology; Brain; Cannabis; Caregivers; Child; Child Development; Child Health; Childhood; Cognition; Cognitive; Collection; Communities; Complex; Congenital Abnormality; Data Collection; Dedications; Detection; Development; Education; Epigenetic Process; Etiology; Evaluation; Exposure to; Family; Fetal Growth; Fetal Reduction; Fetus; Funding; Future; Generations; Genetic; Goals; Health; Healthcare; Heavy Metals; Helping to End Addiction Long-term; Hour; Immune; Individual; Infant; Infant Health; Infrastructure; Knowledge; Language Delays; Language Development; Link; Longitudinal Studies; Low Birth Weight Infant; Maternal Health; Mediating; Memory impairment; Metabolic; National Institute of Drug Abuse; Neonatal Abstinence Syndrome; Opioid; Oregon; Outcome; Parents; Participant; Pathogenicity; Persons; Placenta; Policies; Predisposition; Pregnancy; Pregnant Women; Premature Birth; Prenatal care; Prevention; Prevention strategy; Process; Proteins; Protocols documentation; Psychopathology; Resources; Risk; Sampling; Science; Signaling Protein; Site; Specimen; Tissue Banks; Tissues; Tobacco; Training; Trauma; Umbilical Cord Blood; Umbilical cord structure; United States; Universities; adverse outcome; alcohol consumption during pregnancy; cohort; emotion regulation; experience; fetal; fetal opioid exposure; fetal substance exposure; in utero; inattention; innovation; interest; longitudinal, prospective study; mRNA Expression; maternal opioid use; neonatal health; neurodevelopment; neuroimaging; nutrition; opioid use; opioid use disorder; opioid use in pregnancy; polysubstance use; pregnant; prenatal; prospective; protocol development; racism; recruit; response; sample collection; social; substance use; success; toxicant

PROJECT SUMMARY Opioid use during pregnancy is widespread and associated with adverse outcomes for the pregnant individual and the developing child. Prenatal opioid exposure is associated with a wide range of negative fetal and child outcomes including reduced fetal growth, premature birth, lower birth weight, congenital defects, increased neonatal healthcare, and heightened risk for later behavioral (e.g., anxiety, inattention), cognitive (e.g., memory deficits, delayed language acquisition), and metabolic problems. Despite opioid use being linked to adverse maternal, fetal, and child outcomes, the mechanisms through which these arise and the potential consequences of prenatal opioid exposure for child health and development (e.g., brain and behavior) remain largely unexplored. This lack of etiologic knowledge has contributed to stagnant treatment, prevention, and mitigation efforts leaving individuals and families susceptible to reverberating adverse outcomes. The HEALthy Brain and Child Development (HBCD) Study is a 25-site longitudinal prospective study of early child development in the US that will assess a broad spectrum of biological (e.g., neuroimaging, genetics, epigenetics), behavioral (e.g., cognition and emotional regulation), experiential (e.g., trauma), social (e.g., racism), and health (e.g., psychopathology) factors among ~7,500 nationally-representative pregnant women and their children from pregnancy to mid-childhood. A major goal of the HBCD study is to increase understanding of the potential consequences of prenatal substance exposures. It will be enriched for maternal substance use during pregnancy (i.e., ~25% of the sample will be using opioids, cannabis, alcohol, and/or tobacco during pregnancy and 12% of the total sample will be using opioids) and offers a unique opportunity to inform our understanding of how the adverse consequences associated with opioid use during pregnancy arise. Although HBCD will be the largest long-term study of early brain and child development outcomes in the US, the core protocol does not include the collection of delivery biospecimens. This Administrative Supplement in response to the NIDA/ORWH Administrative Supplement Notice of Special Interests: HEAL Initiative: Biospecimen Collection in Pregnancy (NOT-DA-23-005) proposes to leverage the HEALthy Brain and Child Development (HBCD) by expanding the biospecimen collection of the Core HBCD Protocol to include delivery specimens (placenta, cord tissue, cord blood). Delivery samples will be collected from a representative sample of HBCD Study participants across up to 14 sites (and over 2,000 participants across HBCD sites submitting applications in response to this NOSI). This will provide an unprecedented resource generating opportunity for a larger scientific community to comprehensively evaluate pathophysiological mechanisms that mediate the connection between opioid and polysubstance use during pregnancy and adverse neonatal, infant, and/or maternal health outcomes and, in turn, inform innovative preventive strategies.

项目摘要 妊娠期间使用阿片类药物很普遍，并与妊娠不良结局相关。 个人和发展中的孩子。产前阿片类药物暴露与大范围的阴性胎儿相关。 和儿童结果，包括胎儿生长减少，早产，出生体重较低，先天性缺陷， 新生儿医疗保健增加，后期行为风险增加（例如，焦虑，注意力不集中），认知（例如， 记忆缺陷、语言习得延迟）和代谢问题。尽管阿片类药物的使用与 不利的孕产妇，胎儿和儿童的结果，通过这些产生的机制和潜在的 产前阿片类药物暴露对儿童健康和发育的影响（例如，大脑和行为）仍然存在 大部分未开发。缺乏病因学知识导致了治疗、预防和治疗的停滞， 缓解努力使个人和家庭容易受到负面影响。 健康大脑和儿童发育（HBCD）研究是一项25个研究中心的纵向前瞻性研究， 美国的早期儿童发展，将评估广泛的生物学（例如，神经影像学，遗传学， 表观遗传学），行为（例如，认知和情绪调节），经验的（例如，创伤），社会（例如， 种族主义）和健康（例如，精神病理学）因素在约7，500名全国代表性孕妇中进行了研究 和他们的孩子从怀孕到童年中期。六溴环十二烷研究的一个主要目标是增加对 产前物质暴露的潜在后果。它将被丰富的产妇物质使用 在怀孕期间（即，约25%的样本将使用阿片类药物，大麻，酒精和/或烟草 怀孕和12%的总样本将使用阿片类药物），并提供了一个独特的机会，告知我们的 了解怀孕期间使用阿片类药物的不良后果是如何产生的。虽然 六溴环十二烷将是美国最大的早期大脑和儿童发育结果长期研究， 方案不包括交付生物标本的采集。本行政补充文件 NIDA/ORWH特殊利益行政补充通知：HEAL倡议：生物标本 妊娠期收集（NOT-DA-23-005）建议利用健康大脑和儿童发育 通过扩大六溴环十二烷核心议定书的生物标本采集范围，将交付标本包括在内， （胎盘、脐带组织、脐带血）。将从六溴环十二烷的代表性样品中收集交货样品 多达14个地点的研究参与者（以及提交申请的六溴环十二烷地点的2，000多名参与者） 在这个NOSI中）。这将为更大规模的 科学界全面评估介导这种联系的病理生理机制 妊娠期间使用阿片类药物和多种物质与新生儿、婴儿和/或孕产妇健康不良之间的关系 这将有助于取得成果，并反过来为创新的预防战略提供信息。

项目成果

Delineating early developmental pathways to ADHD: Setting an international research agenda.

描述了ADHD的早期发展途径：设定国际研究议程。

• DOI: 10.1002/jcv2.12144
• 发表时间: 2023-06
• 期刊: JCPP advances
• 作者: Miller, Meghan;Arnett, Anne B.;Shephard, Elizabeth;Charman, Tony;Gustafsson, Hanna C.;Joseph, Heather M.;Karalunas, Sarah;Nigg, Joel T.;Polanczyk, Guilherme V.;Sullivan, Elinor L.;Jones, Emily J. H.
• 通讯作者: Jones, Emily J. H.