A targeted approach to examine the influence of maternal psychological stress on newborn brain outcomes

一种有针对性的方法来检查母亲心理压力对新生儿大脑结果的影响

• 批准号: 9789364
• 负责人: Alice M Graham
• 金额: $ 31.1万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9789364
• 关键词: Amygdaloid structure; Anxiety; Area; Biological; Biological Markers; Biology; Birth; Blood specimen; Brain; Characteristics; Chronic; Clinical; Clinical Sciences; Cognitive; Complex; Conceptions; Control Groups; Corticotropin-Releasing Hormone; Cues; Data; Development; Ecological momentary assessment; Economics; Endocrine; Ensure; Environment; Fetus; Foundations; Funding; Human; Hydrocortisone; Immune; Individual; Individual Differences; Infant; Inflammatory; Interleukin-6; Intervention; Intervention Studies; Learning; Link; Literature; Longitudinal Studies; Magnetic Resonance Imaging; Measurement; Measures; Medial; Mediating; Mediation; Mental Depression; Mental Health; Mental disorders; Mentors; Methodology; Mothers; Natural Disasters; Neuroanatomy; Neurosciences; Newborn Infant; Outcome; Outcomes Research; Pathway interactions; Phase; Prefrontal Cortex; Pregnancy; Pregnant Women; Preventive Intervention; Psychological Stress; Psychopathology; Questionnaires; Randomized Controlled Trials; Research; Research Personnel; Resources; Rest; Risk; Role; Sampling; Scientist; Specificity; Stress; Structure; System; Techniques; Testing; Training; Woman; Work; base; biological systems; career; cost; cytokine; early life stress; emotion regulation; experience; fetal; intervention effect; longitudinal dataset; maternal stress; mindfulness; mindfulness based cognitive therapy; neural correlate; offspring; postnatal; prenatal; prenatal influence; prenatal stress; prospective test; psychosocial; recruit; skills; sleep quality; social; stem; stress reduction; success; symptomatology; tool; trial design

PROJECT SUMMARY/ABSTRACT Associations between heightened maternal psychological stress during pregnancy and increased risk of offspring psychopathology have been demonstrated repeatedly. Evidence points to the integral role of limbic- prefrontal brain systems (LPFS) in mental health outcomes, and the vulnerability of LPFS to early life stress. Methodological advances allow for examining LPFS in newborn infants, increasing capacity to isolate pre- from postnatal influences. The current proposal builds on this work in several key ways. First, although specific characteristics of psychological stress during pregnancy (e.g. intensity, variability, timing) appear to have important implications for offspring outcomes, research on this topic has yielded inconsistent findings. Second, the framework for understanding associations between maternal psychological stress during pregnancy and offspring brain systems remains correlational. This proposal seeks to increase specificity and advance causal understanding regarding the influence of maternal psychological stress during pregnancy on offspring LPFS. The applicant will examine a unique, existing longitudinal dataset of healthy mother-infant dyads (N=86) with extensive characterization of the prenatal environment and newborn structural and resting state functional connectivity MRI (sMRI and rs-fcMRI). Well suited analytic techniques will be used to identify characteristics of maternal psychological stress during pregnancy (based on 4-days of ecological momentary assessment [EMA] in each trimester) most strongly associated with newborn LPFS (K99, Aim 1). The applicant will then examine EMA measured psychological stress in relation to questionnaire-based stress measures and biological indicators (endocrine and immune/inflammatory) to identify less resource intensive alternative markers (K99, Aim 2). The R00 (Aim 3) will focus on a sample of pregnant women enriched for high levels of psychological stress. It will employ a randomized-controlled-trial of an established stress reduction intervention (Mindfulness- Based Cognitive Therapy=60, Cntrl=60) to test the hypothesis that intervention-induced reduction in maternal psychological stress will influence newborn LPFS. The applicant brings a unique background spanning the fields of DOHaD, developmental neuroscience and clinical science. During the K-phase she will extend her training in intervention research with a focus on intervention with pregnant women to test hypotheses stemming from DOHaD. Training in DOHaD will focus on learning analytic techniques for EMA data, and deepening understanding of maternal stress during pregnancy. Building on her strong foundation in developmental neuroscience, the applicant will gain advanced skills to ensure her success as an independent researcher. The team of mentors, Drs. Fair (developmental neuroscience), Buss (DOHAD), Caughey (clinical science and pregnancy) and McEvoy (preventive intervention during pregnancy), provide expertise in all core areas, span all levels of career stage, and bring an excellent record of obtaining independent funding and mentoring young scientists.

项目总结/摘要 怀孕期间母亲心理压力增加与妊娠风险增加之间的关系 后代的精神病理学已经被反复证明。有证据表明边缘系统- 前额叶脑系统（LPFS）在心理健康结果中的作用，以及LPFS对早期生活压力的脆弱性。 方法学的进步允许检查新生儿的LPFS，提高了分离早产儿的能力 产后影响目前的建议以几个关键方式建立在这项工作的基础上。第一，虽然具体 怀孕期间心理压力的特征（例如强度，可变性，时间）似乎具有 对后代结果的重要影响，有关该主题的研究得出了不一致的发现。第二、 了解怀孕期间产妇心理压力与 后代的大脑系统仍然是相关的。该提案旨在提高特异性， 了解孕妇怀孕期间心理压力对后代LPFS的影响。 申请人将检查健康母婴配对的独特、现有纵向数据集（N=86） 随着产前环境和新生儿结构和静息状态功能的广泛表征， 连接性MRI（sMRI和rs-fcMRI）。将使用适当的分析技术来确定 怀孕期间的母亲心理压力（基于4天的生态瞬时评估[EMA]） 在每三个月）与新生儿LPFS（K99，目标1）最密切相关。申请人将审查 EMA测量心理压力与基于压力测量和生物学测量的关系。 指标（内分泌和免疫/炎症）以鉴定资源密集程度较低的替代标志物（K99， 目标2）。R 00（目标3）将侧重于富含高水平心理健康的孕妇样本。 应力它将采用一项已建立的减压干预（正念- 基于认知疗法=60，认知=60），以检验干预引起的孕产妇死亡率降低的假设。 心理应激会影响新生儿LPFS。 申请人带来了跨越DOHaD，发育神经科学领域的独特背景 临床科学。在K阶段，她将扩展她在干预研究方面的培训，重点是 对孕妇进行干预，以检验DOHaD提出的假设。人道主义事务部的培训将侧重于 学习EMA数据的分析技术，加深对怀孕期间母亲压力的理解。 凭借她在发育神经科学方面的坚实基础，申请人将获得先进的技能， 确保她作为独立研究员的成功Fair博士的导师团队（发展 神经科学）、巴斯（多哈）、考伊（临床科学和怀孕）和麦克沃伊（预防性 怀孕期间的干预），提供所有核心领域的专业知识，跨越职业生涯的各个阶段， 获得独立资助和指导年轻科学家的出色记录。