Increasing Recruitment of underrepresented cancer survivors with awareness enhancing interventions (RUN AWEI)

消除癌症健康差距的关键是有能力让种族和少数民族参与研究。 非洲裔美国人(AA)在研究中的代表性不足严重限制了 了解美国残疾人协会和其他种族群体之间不同的健康结果的根本原因 有机会增进关于如何减轻这一弱势群体的癌症负担的知识。查找 增加AA癌症幸存者研究招募的方法是迫在眉睫的。问题是如何做到这一点。我们 建议一种机制是提高对AA潜在参与者的研究的认识，这是一种解决方案 我们之前对AA癌症幸存者的观察性研究(IMPACT)和其他人的研究都支持这一点， 幸存者表示，掌握有关临床试验的信息对他们的决策很重要 关于参与审判的问题。然而，提高AA认识的循证方法在很大程度上仍然存在。 缺席。未知的是需要什么样的战略、信息和视角。我们将测试人们的意识- 增强干预(AWEI)在AA癌症幸存者中这些维度的差异 癌症发病率和死亡率的差异被广泛记录和关注。我们提出了一个高度的 在Amplifi的招募工作中嵌入了创新和高效的析因试验设计(P01 CA22997)。 Amplifi将招募652名癌症幸存者，随机接受生活方式干预。参与者将来自 AAS癌症负担较高的东南部四个州。在Amplifi招聘过程中，2 000人 AA癌症幸存者将被随机分配到8种AWEI条件中的一种，这些条件因策略类型、类型 信息、观点或Amplifi基本招聘战略(无AWEI)。目标是：1：确定 Aweis对AA癌症幸存者招募的影响。我们假设Aweis会有一个 比基本的Amplifi招聘战略(H1)高得多的招聘收益。为配合IMPACT，我们 预计AWEI将产生重大影响，使招聘收益率翻一番；2：确定AWEI的关键特征 这增加了AA癌症幸存者的招募。我们将测试AWEI导航与AWEI- 手册(战略类型，H2)、特定研究与一般研究信息(信息类型，H3)，以及 幸存者“声音”与非(视角类型，H4)将导致更高的招募效率；以及3：确定 在招聘收益和成本方面的最佳AWEI组合。我们假设AWEI 将导航与特定于学习的信息和幸存者的“语音”相结合将是最有效的 并且与其他组合相比可能是最具成本效益的。总而言之，在一项重要试验的基础上 这将过度抽样服务不足的美国各州的少数族裔，我们的专家团队将采用这一创新和 严谨的研究设计，以促进招聘科学，并对美国律师协会的代表性产生重大影响 在研究方面。

Critical to eliminating cancer health disparities is the ability to engage racial and ethnic minorities in research. Inadequate representation of African Americans (AAs) in research severely limits the opportunity to understand underlying causes of disparate health outcomes between AAs and other race groups and the opportunity to advance knowledge on how to reduce the cancer burden in this vulnerable population. Finding ways to increase recruitment of AA cancer survivors in research is urgent. The question is how. We propose that one mechanism is to increase awareness about research in AA potential participants, a solution supported both by our previous observational study (IMPaCT) in AA cancer survivors, and research by others, in which survivors indicated that having information about clinical trials was important in their decision-making regarding trial participation. However, evidence-based methods to increase awareness in AAs remain largely absent. Unknown is what type of strategy, information, and perspective, is needed. We will test awareness- enhancing interventions (AWEI) that vary in these dimensions among AA cancer survivors for whom disparities in cancer incidence and mortality are widely documented and concerning. We propose a highly innovative and efficient factorial trial design embedded into the recruitment effort for AMPLIFI (P01 CA22997). AMPLIFI will recruit 652 cancer survivors to be randomized to lifestyle interventions. Participants will be from four southeastern states with a high burden of cancer in AAs. During the AMPLIFI recruitment process, 2,000 AA cancer survivors will be randomized to one of 8 AWEI conditions that vary by type of strategy, type of information, and perspective, or to the AMPLIFI basic recruitment strategy (No AWEI). Aims are: 1: Determine the impact of AWEIs on recruitment of AA cancer survivors. We hypothesize that AWEIs will have a significantly higher recruitment yield than the basic AMPLIFI recruitment strategy (H1). In line with IMPaCT, we expect AWEI to have a significant impact doubling the recruitment yield; 2: Identify the AWEI key features that increase recruitment of AA cancer survivors. We will test whether AWEI-navigation vs. AWEI- brochure (type of strategy, H2), study-specific vs general research messages (type of information, H3), and, survivor “voice” vs. not (type of perspective, H4) will result in higher recruitment yield; and 3: Determine the optimal AWEI combination in terms of recruitment yield and cost. We hypothesize that AWEI combination of navigation with study-specific messages and the survivor “voice” will be the most efficacious and may be most cost-effective compared to the other combinations. In summary, building on an important trial that will oversample minorities in underserved US states, our expert team will adopt this innovative and rigorous study design to advance the science of recruitment and have a high impact on representation of AAs in research.