Increasing Recruitment of underrepresented cancer survivors with awareness enhancing interventions (RUN AWEI)

消除癌症健康差异的关键是让少数种族和族裔参与研究的能力。 非裔美国人在研究中的代表性不足严重限制了他们的机会， 了解AA和其他种族群体之间不同健康结果的根本原因， 这是一个机会，可以提高关于如何减少这一弱势群体癌症负担的知识。找到 在研究中增加AA癌症幸存者的招募方法是迫切的。问题是怎么做。我们 我建议一种机制是提高AA潜在参与者对研究的认识，这是一种解决方案。 我们之前在AA癌症幸存者中进行的观察性研究（IMPaCT）和其他研究都支持这一点， 其中幸存者表示，获得有关临床试验的信息对他们的决策很重要， 关于参加试验的问题然而，提高AA意识的循证方法在很大程度上仍然存在 无托叶不知道需要什么类型的战略、信息和观点。我们将测试意识- 加强干预措施（AWEI），在AA癌症幸存者中这些方面有所不同， 癌症发病率和死亡率的差异被广泛记录并引起关注。我们提出了一个高度 AMPLIFI招募工作中嵌入的创新和高效析因试验设计（P01 CA 22997）。 AMPLIFI将招募652名癌症幸存者，随机接受生活方式干预。与会者将从 东南部四个州的癌症负担很高。在该特派团的征聘过程中， AA癌症幸存者将被随机分配至8种AWEI条件之一，这些条件因策略类型、 信息和观点，或AMPLIFI基本招聘战略（无AWEI）。目的：1.确定 AWEI对AA癌症幸存者招募的影响。我们假设AWEI将有一个 招募率明显高于基本的AMPLIFI招募策略（H1）。根据IMPaCT，我们 预计AWEI将产生显著影响，使招聘率翻一番; 2：确定AWEI的关键特征 这增加了AA癌症幸存者的招募。我们将测试AWEI-导航与AWEI- 小册子（策略类型，H2），研究特定信息与一般研究信息（信息类型，H3），以及， 幸存者的“声音”与没有（视角类型，H4）将导致更高的招聘率;和3：确定 最优AWEI组合的招聘收益率和成本。我们假设AWEI 将导航与研究特定信息和幸存者“语音”相结合将是最有效的 并且与其它组合相比可能是最经济的。总之，在一次重要审判的基础上， 这将在服务不足的美国州对少数民族进行过度抽样，我们的专家团队将采用这种创新的， 严格的研究设计，以推进招募科学，并对AA的代表性产生重大影响 在研究中。

Critical to eliminating cancer health disparities is the ability to engage racial and ethnic minorities in research. Inadequate representation of African Americans (AAs) in research severely limits the opportunity to understand underlying causes of disparate health outcomes between AAs and other race groups and the opportunity to advance knowledge on how to reduce the cancer burden in this vulnerable population. Finding ways to increase recruitment of AA cancer survivors in research is urgent. The question is how. We propose that one mechanism is to increase awareness about research in AA potential participants, a solution supported both by our previous observational study (IMPaCT) in AA cancer survivors, and research by others, in which survivors indicated that having information about clinical trials was important in their decision-making regarding trial participation. However, evidence-based methods to increase awareness in AAs remain largely absent. Unknown is what type of strategy, information, and perspective, is needed. We will test awareness- enhancing interventions (AWEI) that vary in these dimensions among AA cancer survivors for whom disparities in cancer incidence and mortality are widely documented and concerning. We propose a highly innovative and efficient factorial trial design embedded into the recruitment effort for AMPLIFI (P01 CA22997). AMPLIFI will recruit 652 cancer survivors to be randomized to lifestyle interventions. Participants will be from four southeastern states with a high burden of cancer in AAs. During the AMPLIFI recruitment process, 2,000 AA cancer survivors will be randomized to one of 8 AWEI conditions that vary by type of strategy, type of information, and perspective, or to the AMPLIFI basic recruitment strategy (No AWEI). Aims are: 1: Determine the impact of AWEIs on recruitment of AA cancer survivors. We hypothesize that AWEIs will have a significantly higher recruitment yield than the basic AMPLIFI recruitment strategy (H1). In line with IMPaCT, we expect AWEI to have a significant impact doubling the recruitment yield; 2: Identify the AWEI key features that increase recruitment of AA cancer survivors. We will test whether AWEI-navigation vs. AWEI- brochure (type of strategy, H2), study-specific vs general research messages (type of information, H3), and, survivor “voice” vs. not (type of perspective, H4) will result in higher recruitment yield; and 3: Determine the optimal AWEI combination in terms of recruitment yield and cost. We hypothesize that AWEI combination of navigation with study-specific messages and the survivor “voice” will be the most efficacious and may be most cost-effective compared to the other combinations. In summary, building on an important trial that will oversample minorities in underserved US states, our expert team will adopt this innovative and rigorous study design to advance the science of recruitment and have a high impact on representation of AAs in research.