Biomarkers of Immune Activation in African Americans with CKD
患有 CKD 的非裔美国人免疫激活的生物标志物
基本信息
- 批准号:10397070
- 负责人:
- 金额:$ 3.64万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-07-01 至 2022-07-31
- 项目状态:已结题
- 来源:
- 关键词:APOL1 geneAdaptive Immune SystemAffectAfrican AmericanAfrican American populationAfrican ancestryAmericanAmlodipineApplications GrantsAtherosclerosis Risk in CommunitiesAwardBiological MarkersBiologyBlood PressureChronic Kidney FailureChronic Kidney InsufficiencyClinicalComplexDataData AnalysesData StoreDevelopmentDietary FactorsDietary PotassiumDietary SodiumDisease ProgressionDoctor of PhilosophyEnd stage renal failureEndothelial CellsEnsureEnvironmentEpidemiologyEuropeanExperimental ModelsFunding MechanismsFutureGeneral PopulationGenotypeGoalsHigh PrevalenceHourHuman bodyHypertensionImmuneImmunologic MarkersIn VitroIndividualIntakeInterferon Type IIInterventionInvadedInvestigationK-Series Research Career ProgramsKidney DiseasesLettersLinkMeasurementMeasuresMentorsMentorshipMethodsMetoprololMolecular EpidemiologyNephrologyOutcomeOxidative StressPathway interactionsPharmaceutical PreparationsPhasePopulations at RiskPotassiumRamiprilRandomizedRenal functionReproducibilityResearchResearch DesignResearch PersonnelResearch Project GrantsResourcesRiskRisk FactorsRoleSamplingScientistSerumSodiumSodium ChlorideSystemTNF geneTimeTrainingTryptophan Metabolism PathwayTumor Necrosis Factor ActivationTumor Necrosis Factor ReceptorUnited States National Institutes of HealthUniversitiesUrineVisitWaterblood pressure controlblood pressure interventionblood pressure medicationcareercohortdemographicsdiabetic patientendothelial dysfunctionexperiencefatty acid oxidationfollow-upgenetic epidemiologygenetic risk factorhigh riskimmune activationimprovedinsightmedical schoolsmetabolomicsmicroorganismnon-diabeticnovelpodocytepredictive markerprofessorrandomized trialreceptorrisk variantskillstreatment armtrial design
项目摘要
PROJECT SUMMARY/ABSTRACT
Teresa K. Chen, MD, MHS is an Assistant Professor in the Division of Nephrology at Johns Hopkins University
School of Medicine. She is applying for a K08 Mentored Clinical Scientist Research Career Development
Award in order to acquire the necessary skills and mentored research experience to become an independent
investigator in the field of chronic kidney disease (CKD). The proposed 5-year plan includes advanced
coursework in epidemiology; practical experience in the measurement of biomarkers; and mentorship by an
extraordinarily experienced, committed and diverse mentorship team [co-primary mentors, Lawrence Appel,
MD, MPH and Morgan Grams, MD, PhD; co-mentor, Michelle Estrella, MD, MHS]. With resources provided by
this award, Dr. Chen will develop proficiencies in study design, genetic and molecular epidemiology, and
longitudinal data analysis related to CKD. Her proposed research project focuses on the role of immune
activation in CKD progression and the interactive effects of immune activation with APOL1 risk variants.
African Americans are disproportionately affected by CKD. This is in part due to the higher prevalence of
APOL1 risk variants, genetic risk factors for kidney disease among individuals of African ancestry. The role of
immune activation in the progression of non-diabetic CKD, particularly in APOL1 high-risk individuals, is
unclear. The objectives of the proposed research are to: 1) study the associations of biomarkers of immune
activation with CKD progression among non-diabetic African Americans with CKD attributed to hypertension; 2)
determine whether the APOL1-associated risk for CKD progression is augmented by immune activation; 3)
assess whether blood pressure interventions and dietary factors are associated with longitudinal changes in
biomarkers of immune activation; 4) identify metabolomic predictors of biomarkers of immune activation. With
over 10 years of follow-up, rigorously collected data, and stored biospecimens, the African American Study of
Kidney Disease and Hypertension (AASK) represents an ideal cohort in which to study these potential
associations. APOL1 genotyping and metabolomics measurements have previously been completed in AASK
through other NIH-funded mechanisms. We propose to use stored serum samples from the baseline and 12-
month visits of the trial phase to measure the following biomarkers of immune activation: tumor necrosis factor
alpha (TNF-α), soluble TNF receptors 1 and 2 (sTNFR1 and sTNFR2), and interferon gamma (IFN-γ).
The results of the proposed study will clarify the role of immune activation in CKD progression and perhaps
identify novel targets for intervention. This could have important clinical implications in the treatment of African
Americans with non-diabetic CKD, particularly among those with the APOL1 risk variants. The proposed
research will also support Dr. Chen's long term-goal of transitioning towards an independent research career
that ultimately improves the management and outcomes of African Americans with CKD. The rich training
environment of Johns Hopkins University will ensure that she achieves these goals.
项目总结/文摘
项目成果
期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Teresa Chen其他文献
Teresa Chen的其他文献
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{{ truncateString('Teresa Chen', 18)}}的其他基金
Biomarkers of Immune Activation in African Americans with CKD
患有 CKD 的非裔美国人免疫激活的生物标志物
- 批准号:
9898372 - 财政年份:2019
- 资助金额:
$ 3.64万 - 项目类别:
Biomarkers of Immune Activation in African Americans with CKD
患有 CKD 的非裔美国人免疫激活的生物标志物
- 批准号:
10686752 - 财政年份:2019
- 资助金额:
$ 3.64万 - 项目类别:
Biomarkers of Immune Activation in African Americans with CKD
患有 CKD 的非裔美国人免疫激活的生物标志物
- 批准号:
10702184 - 财政年份:2019
- 资助金额:
$ 3.64万 - 项目类别:
Biomarkers of Immune Activation in African Americans with CKD
患有 CKD 的非裔美国人免疫激活的生物标志物
- 批准号:
10887000 - 财政年份:2019
- 资助金额:
$ 3.64万 - 项目类别:
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