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CT-Based Modeling of Bone Micro-Architecture and Fracture-Risk in COPD

基于 CT 的 COPD 骨微结构和骨折风险建模

基本信息

批准号：
10397540
负责人：
PUNAM K. SAHA
金额：
$ 72.95万
依托单位：
UNIVERSITY OF IOWA
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-01 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10397540
关键词：
3-Dimensional Age Agreement Ankle Architecture Area Bone Density Bone structure Characteristics Chronic Obstructive Pulmonary Disease Clinical Computed Tomography Scanners Data Development Distal Dose Dual-Energy X-Ray Absorptiometry Fracture Glucocorticoids Goals High Resolution Computed Tomography Hip region structure Image Incidence Individual Intake Intervention Iowa Knowledge Lateral Link Lung Measures Mechanics Methodology Modeling Morbidity - disease rate Osteoporosis Participant Pathology Patients Performance Peripheral Phenotype Physical activity Population Porosity Prevalence Radial Risk Risk Factors Rod Scanning Site Skeleton Spinal Fractures Subgroup Testing Therapeutic Intervention Thick Training Universities Vendor Vertebral column Visit Weight-Bearing state Wrist X-Ray Computed Tomography base bone bone loss bone strength cohort comorbidity cortical bone disorder subtype follow-up fracture risk histological studies image processing lumbar vertebra bone structure mortality never smoker predictive modeling pulmonary function radiological imaging recruit response sex spine bone structure substantia spongiosa systemic inflammatory response thoracic vertebra bone structure tibia tool translational goal translational study

项目摘要

This translational study seeks to establish a Chronic Obstructive Pulmonary Disease (COPD)-specific fracture prediction model using our unique computed tomography (CT)-based assessment of peripheral bone micro- architecture. Osteoporosis, a common comorbidity among patients with COPD, accelerates morbidity and mortality. The basis for this comorbidity is poorly understood, thus the need for characterizing the link between COPD-related factors and bone micro-architecture and their association to fracture-risk. Multiple COPD-related factors are associated with osteoporosis. Different COPD-related causes of bone loss may non-uniformly impact cortical and trabecular bone structures with varying mechanical consequences, reflective of divergent COPD- associated fracture-risk in individuals with similar bone mineral density (BMD). Little is known about this linkage, and our goal is to fill this knowledge gap using a clinically suitable emerging CT-based tool for characterization of bone micro-architecture at peripheral sites. Specifically, this study will—(1) establish the generalizability of our bone micro-architecture assessment applied to emerging low dose / high resolution CT scanners from different vendors; (2) assess its potential as compared to dual energy x-ray absorptiometry (DXA) to explain prevalent fractures and predict incident fractures among patients with COPD; (3) quantify the impact of different COPD- related factors on bone structures and their implications for fracture-risk; (4) identify COPD subtypes with rapid bone structural degeneration; and (5) develop a COPD-specific model for assessment of fracture-risk using patient-specific data. We will take advantage of—(1) existing COPD patient cohorts with lung characterization at the University of Iowa (UI) and Columbia University (CU) representing a wide demographic range; (2) access to emerging CT scanners at both sites; and (3) unique image processing methodologies for quantifying three- dimensional bone structural metrics. We will recruit 470 COPD patients from the UI and CU cohorts and 80 age- sex-similar never-smoker controls. At baseline and 3-year follow-up visits, we will collect—(1) data related to risk factors; (2) a lateral spine CT scout scan to assess vertebral fractures; (3) high resolution CT scans of the ankle and wrist for computation of bone structural metrics; and (4) whole-body, spine and hip DXA. Siemens Force CT scanners will be used for all participants except for 100 randomly-selected patients and controls from the UI cohort who, instead, will be imaged via a Toshiba Aquilion ONE 320 scanner. This study will establish an emerging CT-based scanner-independent generalizable tool to assess bone response to different therapeutic interventions aimed at slowing or reversing bone loss, and possibly restoring bone structure, potentially leading to more patient-specific interventions. Also, this study seeks to explain the relationships among various COPD- related factors, bone structural changes and their implications for fracture-risk. Finally, a COPD-specific model for assessment of fracture-risk will be developed that will utilize patient-specific demographic, clinical and radiographic data, and CT BMD at the spine, as well as bone structural measures at the wrist and/or ankle.

这项转化性研究旨在建立慢性阻塞性肺疾病（COPD）特异性骨折

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Anatomical Labeling of Human Airway Branches using a Novel Two-Step Machine Learning and Hierarchical Features.

使用新颖的两步机器学习和分层特征对人体气道分支进行解剖标记。

DOI：
10.1117/12.2546004
发表时间：
2020
期刊：
Proceedings of SPIE--the International Society for Optical Engineering
影响因子：
0
作者：
Nadeem,SyedAhmed;Hoffman,EricA;Comellas,AlejandroP;Saha,PunamK
通讯作者：
Saha,PunamK

Finite element analysis of trabecular bone microstructure using CT imaging and continuum mechanical modeling.

DOI：
10.1002/mp.15629
发表时间：
2022-06
期刊：
MEDICAL PHYSICS
影响因子：
3.8
作者：
Guha, Indranil;Zhang, Xiaoliu;Rajapakse, Chamith S.;Chang, Gregory;Saha, Punam K.
通讯作者：
Saha, Punam K.

CT-Based Characterization of Transverse and Longitudinal Trabeculae and Its Applications.

基于 CT 的横向和纵向小梁表征及其应用。