Core A - AdministrativeCore/Biocomputational Unit

摘要 行政核心将继续协调四个项目和四个项目的不同活动 本计划项目(PP)的核心。回应不同项目的需求，妥善处理 整合项目和核心在此期间将生成的大量数据，我们有 包括作为新的核心组成部分的生物统计和数据管理股(见方案规划案文 作为生物统计股)，将完全致力于数据分析、管理和整合。 这个核心的长期目标有两个：1)作为不同部分的整合中心 作为PP与我们内外的调查人员和资源的联系 学校和2)确保所有数据都将得到适当的收集、管理、分析和整合。 这个由两部分组成的核心的具体目标是：a)行政(AC)：1)为 具有项目运作所需的专职行政和秘书支持的PP， 2)协调向科学委员会其他成员转让材料和试剂的审批 社区，3)促进不同PP成员之间的沟通，4)监督和评估 PP的科学进步，5)促进PP与我们相关利益中心的互动 6)提高老龄研究意识。B)生物统计和数据管理 (BDMU)：1)为研究设计和假设的制定提供指导，2)开发安全的中心 数据库系统，3)实施最先进的数据分析技术，4)协助调查结果 5)提供统计方法方面的培训机会。 构成部分：行政事务、执行委员会和科学咨询委员会 (由主任监督和协调)和BDMU的专家(由单位主任监督)。 提供的服务：a)行政和秘书支持专为本方案规划的需要量身定做 (订购试剂和用品、财务和进度报告、协助预算管理、 处理材料转让协议)、组织每周会议、每月进行中工作和 与科学咨询委员会举行一年两次的会议。B)实验设计、功率分析、 数据收集规划、数据分析、大数据管理、基于Web的数据集成、数据存储、 关于统计分析和最佳做法的培训，以确保严密性和可重复性。 相关性：这个核心对于将项目和核心集成到一个连贯的计划中是必不可少的，该计划允许 在阐明器官和系统功能衰退的基础方面取得更快、更有效的进展 随着年龄的增长，以及在阿尔茨海默病相关蛋白毒性的背景下。在这一凝聚力计划的基础上 是该计划成员之间自由和高效的科学成果交流的活跃 审查进展情况和资源利用情况，并确定共同的未来目标和方向。

Summary The Administrative Core will continue coordinating the different activities of the four Projects and four Cores of this Program Project (PP). To respond to the demands of the different projects and to properly integrate the large amount of data that will be generated by projects and cores during this period, we have included as a new core component the Biostatistics and Data Management Unit (referred in the PP text as Biostatistics Unit) that will be fully dedicated to data analysis, management, and integration. The long-term goal of this core is two-fold: 1) to serve as the center of integration for the different parts of this collaborative effort and as a liaison of the PP with investigators and resources in and outside our school and 2) to assure that all data will be appropriately collected, managed, analyzed and integrated. The specific aims of this two-component core are: A) Administration (AC): 1) to provide the members of the PP with dedicated administrative and secretarial support required for the functioning of their programs, 2) to coordinate approval for transferring of materials and reagents to other members of the scientific community, 3) to facilitate communication among the different PP members, 4) to monitor and evaluate the scientific progress of the PP, 5) to promote interactions of the PP with Centers with related interests in our school and outside, 6) to increase awareness for aging research. B) Biostatistics and Data Management (BDMU): 1) to provide guidance on study design and formulation of hypothesis, 2) to develop a secure central database system, 3) to implement state-of-the-art techniques for data analysis, 4) to assist with findings interpretation/dissemination, 5) to offer training opportunities in statistical methods. Components: the administrative service, the Executive Committee and the Scientific Advisory Committee (overseen and coordinated by the director) and the experts of the BDMU (overseen by the unit director). Services offered: A) administrative and secretarial support exclusively tailored the needs of this PP (ordering of reagents and supplies, financial and progress reports, assistance with budget management, handling of material transfer agreements), organization of weekly meetings, monthly work-in-progress and of the biannual meetings with the Scientific Advisory Committee. B) experimental design, power analysis, data collection planning, data analysis, large data curation, web-based data integration, data storage, training on statistical analysis and on best practices to assure rigor and reproducibility. Relevance: This core is essential for integration of projects and cores into a cohesive program that allows for faster and efficient progress toward the elucidation of the basis for functional decline of organs and systems with age and in the context of Alzheimer’s disease-related proteotoxicity. In the basis for this cohesive program is the free and efficient communication of scientific results among the members of the program, the active review of progress and utilization of resources and the delineation of a common future goal and direction.