2010 Biology of Aging Gordon Research Conference and/or Gordon Research Seminar

描述（由申请人提供）：戈登衰老生物学研究会议（GRC）自1962年以来每18个月举行一次，是2010年由GRC组织的170多个会议的一部分，GRC是一个因其会议的高质量前沿性质而闻名于世的组织。本应用程序中描述的2010年GRC衰老生物学计划是围绕“健康跨度的决定因素：从细胞到人类”这一主题开发的，这将作为讨论最近在感知、测量和研究衰老方式方面出现的变化的基础。衰老是一个多因素的复杂过程，是遗传、生化和生理水平变化共同作用的结果。近年来，我们对衰老和年龄相关疾病的细胞和动物模型的这些变化的理解取得了令人眩晕的进展。这一领域目前面临的挑战是双重的：1)继续并完成对导致衰老的因素的分子解剖；2)促进将这些新发现转化为干预措施，以改善我们老龄化人口的健康寿命。这次戈登研究会议将汇集国际领先的专家，他们对衰老生物学的各个方面有广泛的兴趣，并将创建一个高质量的科学论坛，讨论衰老的基本机制及其实施干预措施，旨在提高老龄化人口的健康质量。此外，在本次会议的历史上，第一次，会议前戈登研究研讨会将由初级研究者（学生和博士后水平）组织。研讨会期间的活动完全面向初级研究人员，旨在1)为他们提供必要的衰老生物学基础知识，以最大限度地了解会议所讨论的科学；2)从该领域的专家那里获得他们正在进行的研究项目的反馈；3)促进他们与该科学界的资深成员的互动，促进年轻一代衰老研究人员之间的联系。意义：我们充分期待本次会议参与者之间的科学讨论、研究会谈和非正式互动将有助于促进我们对与衰老相关的功能衰退背后的分子机制的理解，并将为旨在促进人类健康衰老的协作干预的发展奠定基础。

DESCRIPTION (provided by applicant): The Gordon Research Conference (GRC) on Biology of Aging has been held every 18 months since 1962 and is part of the over 170 conferences that will be organized in 2010 by GRC, an organization known world-wide because of the high-quality cutting-edge nature of its conferences. The program for the 2010 GRC on Biology of Aging described in this application has been developed around the theme "Determinants of Health-span: from cell to humans" which will serve as a basis for discussion of the recently emerging changes in the way in which aging is perceived, measured and studied. Aging is a multifactorial and complex process that results from changes at the genetic, biochemical and physiological level. Our understanding of those changes in cellular and animal models of aging and age-related disorders has advanced vertiginously during recent years. The current challenge of this field is two-fold: 1) to continue and complete the molecular dissection of the factors that contribute to aging and 2) to promote the translation of these novel findings into interventions to improve the health-span of our aging human population. This Gordon Research Conference will bring together leading international experts with a broad range of interests related to diverse aspects of biology of aging, and will create a high quality scientific forum for discussion of findings on the basic mechanisms of aging and their implementation into interventions aimed at increasing quality of heath in the aging population. Furthermore, for the first time in the history of this conference, a pre-conference Gordon Research Seminar will be organized by junior investigators (student and postdoctoral level). The activities during the Seminar are completely oriented to junior investigators and are intended to 1) provide them with the basic background on Biology of Aging necessary to maximize their understanding of the science discussed in the conference, 2) receive feedback on their ongoing research projects from experts in the field and 3) facilitate their interaction with senior members of this scientific community and promote networking in between the junior generation of aging researchers. Significance: We fully anticipate that the scientific discussions, research talks and informal interactions between the participants in this conference will contribute to advance our understanding of the molecular mechanism behind the functional decline associated to aging and will set the basis for the development of collaborative interventions aimed at promoting healthy human aging. PUBLIC HEALTH RELEVANCE: The Gordon Research Conference on Biology of Aging will bring together major leaders in different basic scientific disciplines (biochemistry, cell biology, genetics, etc.) and in clinical areas of relevance to gerontology (neuropathology, endocrinology, experts in metabolism, etc.) along with junior investigators that will constitute the future generation of researchers with interest in the field of aging and who will participate in addition in the pre-meeting Gordon Research Seminar. The scientific presentations, discussions and workshops during this conference will contribute to advance our understanding of the reasons for the functional decline that occurs in aging individuals and the increased incidence of certain pathologies in elders. It is anticipated that the collegial and cooperative atmosphere that has traditionally characterized this conference will provide the perfect setting for the intellectual development and future implementation of interventions to assure healthy aging.