Functional MRI Core Facility

空间利用率： FMRIF目前占地约4800平方英尺。3T-1、3T-2和核磁共振中心的FMRIF 1.5T系统(分别约1500平方英尺、1100平方英尺和800平方英尺)，以及核磁共振中心和二楼FMRIF/SFIM套房内的办公空间(总计约1400平方英尺)，用于该设施所有11名全职工作人员的办公空间和共享会议空间。此外，我们的扫描仪模拟器的临时空间已经借给了FMRIF 核心用户。 功能磁共振成像设施支持大约22个PI的研究，换算成总共大约250名研究人员。大约有70个正在使用的IRB协议正在使用FMRIF扫描仪。每台扫描仪的计划工作时间为每周105小时。作为扫描仪一致性的一个例子，2003年，3T-1和3T-2分别运行了303天和280天。 核心设施的工作人员科学家(以及GE工程师)在维护扫描仪方面变得更加高效，并制定了每日质量保证检查，因此2006年的趋势是3T1和3T2都将在95%以上的时间内运行(请注意：3T1在2004-2006年经历了几次重大升级，导致停机时间略长)。 核心设施的NIMH使用率 我们正在汇编按扫描仪、时间段(黄金时间、晚上和周末)、研究所和PI以及年份细分的核心设施使用情况的更详细统计数据。这正在变成一个极其复杂的过程。同时，我们决定报告所有核心设备扫描仪的使用情况，以及NIMH在NMRF 3T上的时间使用情况。下面的图表总结了过去一年的每小时使用量(每周平均小时数)。 黄金时间晚间周末总计% 3T-1 31 10 15 56 53.3 3T-2 27 5 21 53 50.5 NMRF 3T 8 5 6 19 18.1 FMRIF 1.5T 12.3 11.3 8.3 32 30.3 总计78.3 31.3 50.3 160 MRI使用带来的高影响力出版物 林登伯格，A.，J.W.巴克霍尔茨等人。(2006年)。“人类冲动和暴力的遗传风险的神经机制。”美利坚合众国国家科学院学报103(16)：6269-6274。 Shaw，P.，D.Greenstein等人。(2006年)。“儿童和青少年的智力和皮质发育。”自然440(7084)：676-679。 Pessoa，L.，S.Japee等人(2006年)。“目标的可见性和视觉感知调节了杏仁核对恐惧面孔的反应。”大脑皮质16(3)：366-375。 书名/作者：Reinessy/C.S.Monk.(2007)。“儿童广泛性焦虑症患者恐惧回路功能的异常注意调节。”《普通精神病学档案》：97-106。

Space Utilization: The FMRIF currently occupies approximately 4800 sq. ft of space, divided between the scanner bays, control rooms and electronics/machine rooms for 3T-1, 3T-2, and the FMRIF 1.5T system in the NMR Center (about 1500 sq ft, 1100 sq ft and 800 sq ft respectively) and office space within the NMR center and on the second floor FMRIF/SFIM suite (approximately 1400 sq ft total) for office space and shared conference space for all 11 staff employed full-time by the facility. In addition temporary space for our scanner simulator has been loaned to the FMRIF Core users. The functional MRI facility supports the research of about 22 PIs which translates to about 250 researchers overall. Approximately 70 active IRB protocols are active and making use of FMRIF scanners. Each scanner has schedule operating hours of 105 hours per week. As an example of scanner consistency, in 2003, 3T-1 and 3T-2 were operational for 303 and 280 days respectively. The staff scientists of the core facility (as well as the the GE engineers) have become much more efficient in their upkeep of the scanners and have developed a daily check for quality assurance, so that the current trend in 2006 is that both 3T1 and 3T2 will be operational more than 95% of the time (note that: 3T1 had undergone several major upgrades in 2004-2006 resulting in slightly more downtime). NIMH Usage of Core Facilities We are compiling more detailed statistics of core facility usage broken down by scanner, time slot (prime, evening, and weekend), Institute and PI, and year. This is turning into an extremely involved process. In the mean time, we decided to report an example of usage of all core facility scanners, as well as usage of the time on the NMRF 3T by NIMH. The chart below summarizes this hourly usage (average hours per week) over the past year. Prime Evening Weekend Total Total % 3T-1 31 10 15 56 53.3 3T-2 27 5 21 53 50.5 NMRF 3T 8 5 6 19 18.1 FMRIF 1.5T 12.3 11.3 8.3 32 30.3 Total 78.3 31.3 50.3 160 High Impact Publications Resulting from MRI Usage Meyer-Lindenberg, A., J. W. Buckholtz, et al. (2006). "Neural mechanisms of genetic risk for impulsivity and violence in humans." Proceedings of the National Academy of Sciences of the United States of America 103(16): 6269-6274. Shaw, P., D. Greenstein, et al. (2006). "Intellectual ability and cortical development in children and adolescents." Nature 440(7084): 676-679. Pessoa, L., S. Japee, et al. (2006). "Target visibility and visual awareness modulate amygdala responses to fearful faces." Cerebral Cortex 16(3): 366-375. McClure, E., C. S. Monk, et al. (2007). "Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder." Archives of General Psychiatry 64: 97-106.