Functional MRI Core Facility

方案编号93-M-0170，NCT 00001360 空间利用率： 功能性磁共振成像设施（FMRIF）目前占地约4800平方米。300平方英尺的空间，分为扫描仪间、控制室和3 TA、3 TB、3 TC、3 TD和7 T MRI扫描仪的电子/机器室，位于NMR中心内，办公空间位于NMR中心上方的二楼，位于FMRIF/Scrum套房内（总面积约为1400平方英尺，包括共享会议空间）。 FMRIF工作人员（目前有14个全职职位）包括：设施主管、三名保持扫描仪运行的科学家、六名MRI技术人员、一名信息技术专家、一名程序员、一名技术实验室经理和一名行政实验室经理。 功能性磁共振成像设施支持30多名主要研究人员的研究，总共有300多名研究人员。超过70个研究方案正在使用FMRIF扫描仪。每台扫描仪的预定工作时间为每周105小时。 自2000年成立至2016年8月，共有1069篇来自内部研究人员的同行评审出版物使用了FMRIF核心设施中获得的数据。其中NIMH的716篇，NINDS的257篇，其他研究所的96篇。这些论文共被引用95，390次，综合h指数为152。换句话说，使用FMRIF的152篇论文被引用至少152次。 项目： 我们在3 TD上完成了高密度（128通道）EGI MRI兼容系统的安装，并培训了MRI技术人员。该系统目前正用于氯胺酮在3 TD上的试点研究，以及与Leo Cohens小组合作的一项研究，该研究将静息MEG和静息EEG/FMRI结合在中风康复中。 Jan Varada已经组装了一个MRI质量控制处理管道，该管道可能用于确保在神经成像数据库组装时数据质量保持恒定的高质量。 已经建立了7 T pTX项目的标准工作流程，正在准备提交，以允许人类使用8 Tx/32 Rx系统（与Jeff Duyn小组合作）。 在7 T上安装了一个新的高性能图像重建系统，现在允许常规使用多波段、多回波（以前禁止使用）。我们已经展示了常规2s TR，1.1mm ISO GE-EPI（100层）。我们已经测试并安装了CMRR、MGH和马斯特里赫特的多波段序列。 我们在所有西门子扫描仪上安装并测试了磁共振研究中心（明尼苏达大学）多波段序列。这些序列现在常规用于LBC方案的3 TD。 我们已获得GE MR 750平台的斯坦福大学多波段EPI序列。我们正在将其移植到Epic 22.x，以便在3 TC上使用。 主要是由于Vinai Roopchansingh的工作，我们已经发布了基本的GE（管弦乐队）原始数据到ISMRM-RD转换器。 我们已经将NIH-EPI（支持多回波）移植到Prisma。该序列被NIH的研究人员广泛使用，并被分发（作为西门子C2 P序列）到其他网站。我们还将NIH-3D-EPI（即分段3D EPI）移植到Siemens Prisma平台。这是现在使用的赖希集团（帕斯卡萨蒂），并正在分发（作为西门子C2 P序列）到其他网站。

Protocol number 93-M-0170, NCT00001360 Space Utilization: The Functional MRI Facility (FMRIF) currently occupies approximately 4800 sq. ft of space, divided between the scanner bays, control rooms and electronics/machine rooms for 3TA, 3TB, 3TC, 3TD, and 7T MRI scanners located within the NMR center and office space on the second floor above the NMR center in the FMRIF/SFIM suite (approximately 1400 sq ft total, including shared conference space). The FMRIF staff (currently 14 full- time positions) consists of: the facility director, three staff scientists to keep the scanners running, six MRI technologists, an information technology specialist, a programmer, a technical laboratory manager, and an administrative laboratory manger. The functional MRI facility supports the research of over 30 Principal Investigators translating to over 300 researchers overall. Over 70 research protocols are active and making use of FMRIF scanners. Each scanner has scheduled operating hours of 105 hours per week. Since its inception in 2000 until August 2016, a total of 1069 peer-reviewed publications from intramural investigators have used data acquired in the FMRIF core facility. The total is distributed among 716 papers from NIMH, 257 papers from NINDS, and 96 from the other institutes. These papers have been cited a total of 95,390 times for a combined h-index of 152. In other words, 152 papers using the FMRIF have been cited at least 152 times. Projects: We completed installation of the high-density (128 channel) EGI MRI compatible system on 3TD and trained MRI technologists. The system is currently being used in pilot studies of ketamine on 3TD as well as a assisting with a study with Leo Cohens group that combines resting MEG and resting EEG/FMRI in stroke rehabilitation. Jan Varada has assembled an MRI quality control processing pipeline that will likely be used for making sure that the data quality remain of a constant high quality as the neuroimaging database becomes assembled. A standard workflow for the 7T pTX project has been established and submission is in preparation to allow human use of the 8Tx/32Rx system (in collaboration with the Jeff Duyn group). A new high-performance image reconstruction system was installed on the 7T that now permits routine use of multi-band, multi-echo (prohibitive before). We have demonstrated routine 2s TR, 1.1mm iso GE-EPI (100 slices). We have tested and installed multi-band sequences from CMRR, MGH and Maastricht. We installed and tested the Center for Magnetic Resonance Resaerch (University of Minnessota) Multi-band sequences on all Siemens scanners. These sequences are now being used routinely on 3TD for LBC protocol. We have gained access to a Stanford multi-band EPI sequence for GE MR750 platform. We are in the process of porting it to Epic 22.x for use on 3TC. Thanks mostly to the work of Vinai Roopchansingh, we have published the base GE (Orchestra) Raw Data to ISMRM-RD converter. We have ported NIH-EPI (supports multi-echo) to Prisma. The sequence is in wide use with researchers at NIH, and is being distributed (as a Siemens C2P sequence) to other sites. We also ported NIH-3D-EPI (i.e. segmented 3D EPI) to Siemens Prisma plaform. This is now in use with the Reich group (Pascal Sati), and is being distributed (as a Siemens C2P sequence) to other sites.