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Pilot Projects and Trans-Network Activities

试点项目和跨网络活动

基本信息

批准号：
10733397
负责人：
Moon Shao-Chuang Chen
金额：
$ 0.34万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-01 至 2028-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10733397
关键词：
Achievement Administrator Affect African American Asian Americans Basic Cancer Research California Cancer Model Cancer Patient Cells Collaborations Collection Comprehensive Cancer Center Conduct Clinical Trials Data Commons Decision Making Development Discipline Disparity Doctor of Philosophy Drug Combinations Ensure Evaluation Fostering Funding Goals Grant Health Disparities Research Human Resources International Latino Latino Population Lead Los Angeles Lung Neoplasms Malignant Neoplasms Malignant neoplasm of lung Methods Minority Groups Monitor Moon Native Hawaiian Pacific Islander Pathology Pharmaceutical Preparations Phase Pilot Projects Preclinical Testing Procedures Reproducibility Research Research Personnel San Francisco Site Stomach Neoplasms System Technology Testing Texas Universities Validation Woman Xenograft procedure cancer health disparity chemotherapy community engagement design drug testing efficacy validation ethnic minority ethnic minority population experience innovative technologies malignant stomach neoplasm meetings minority patient novel novel therapeutics patient derived xenograft model people of color pre-clinical precision oncology preclinical study programs racial minority racial minority population repository symposium targeted treatment treatment response tumor

项目摘要

PILOT PROJECTS AND TRANS-NETWORK ACTIVITIES CORE University of California and UT Southwestern Diversity Patient-Derived Xenograft (PDX) Development and Trial Center (UCaTS) to Reduce Cancer Health Disparities PROJECT SUMMARY/ABSTRACT The goal of the Pilot Projects and Trans-Network Activities Core (PPTNAC) is to contribute to the achievement of the University of Californiaand UT Southwestern Diversity Patient-Derived Xenograft (PDX) Development and Trial Center (UCaTS) overall objectives of developing PDX trial strategies for preclinical testing of single agents and drug combinations. This D-PDTC focuses on the predominant racial/ethnic minority populations residing in California and Texas, namely, Latinos, African American [AAs] and Asian American/Native Hawaiian/Pacific Islander [AANHPIs]. The focus will be on gastric cancer which disproportionately affect Latinos and all populations of color, and lung cancer, which has a high burden in Latino and AANHPI women. Key personnel for this Core include the PPTNAC Lead Moon S. Chen, Jr., who has successfully led PPTNAC in our ongoing UCaMP PDX Development and Trial Center (PDTC), all Site PIs, Contact PI and Administrative Core Lead Luis Carvajal-Carmona, and UCaTS Grant Administrator. As such, PPTNAC investigators reflect multiple relevant disciplines that foster the evaluation of pilot studies and trans-network activities including cancer health disparities, pre-clinical studies, pathology, and basic cancer research. PPTNAC will also facilitate the interaction of UCaTS with NCI, PDXNet Data Commons and Coordinating Centers (PDCCC), other PDTCs, and non- PDXNet investigators through funded projects. Specifically, the PPTNAC Aims are to: (1) Facilitate Internal Pilot Projects; (2) Facilitate Cross-PDXNet Activities (Pilot Studies Development and Evaluation); and (3) Engage Non-Network Investigators; and (4) Share Innovative Technologies using PDXs (Collaboration with non-PDXNet investigators).

试点项目和跨网络活动核心加州大学和UT西南多样性患者衍生异种移植物（PDX）开发和试验中心（UCaTS），以减少癌症健康差异项目总结/摘要试点项目和跨网络活动核心（PPTNAC）的目标是促进实现加州大学和UT西南多样性患者衍生异种移植（PDX）的发展和临床试验中心（UCaTS）制定用于单药临床前试验的PDX试验策略的总体目标和药物组合。这一D-PDTC侧重于居住在以下地区的主要种族/少数民族人口：加州和德克萨斯州，即拉丁美洲人、非洲裔美国人[AA]和亚裔美国人/夏威夷原住民/太平洋裔岛民[AANHPI]。重点将放在胃癌上，胃癌对拉丁裔和所有人的影响不成比例有色人种和肺癌，在拉丁美洲和AANHPI妇女中负担很高。关键人员包括PPTNAC Lead Moon S。小陈，他成功地领导了PPTNAC， UCaMP PDX开发和试验中心（PDTC）、所有研究中心PI、联系PI和管理核心负责人Luis Carvajal-Carmona和UCaTS Grant管理员。因此，PPTNAC研究人员反映了多个相关的促进评估试点研究和跨网络活动的学科，包括癌症健康差异、临床前研究、病理学和基础癌症研究。PPTNAC还将促进互动 UCaTS与NCI，PDXNet数据共享和协调中心（PDCCC），其他PDTC，以及非 PDXNet调查员通过资助的项目。具体而言，PPTNAC的目标是：（1）促进内部试点项目;（2）促进跨PDXNet活动（试点研究开发和评估）;以及（3）参与非网络调查员;以及（4）使用PDX共享创新技术（与非PDXNet合作调查员）。