Pilot Projects and Trans-Network Activities

试点项目和跨网络活动核心 加州大学和德克萨斯大学西南分校患者来源异种移植(PDX)的开发 和试验中心(UCATS)减少癌症健康差距 项目摘要/摘要 试点项目和跨网络活动核心(PPTNAC)的目标是促进实现这一目标 加州大学和德克萨斯大学西南分校患者来源的异种移植(PDX)开发和 试验中心(UCATS)开发用于单药临床前试验的PDX试验策略的总体目标 以及药物组合。这项D-PDTC的重点是居住在 加利福尼亚州和德克萨斯州，即拉丁裔、非裔美国人[AAS]和亚裔美国人/夏威夷原住民/太平洋 岛民[AANHPI]。重点将放在胃癌上，这对拉丁裔和所有人都有不成比例的影响 有色人种和肺癌，这在拉丁裔和AANHPI妇女中负担很重。关键人员 这一核心包括PPTNAC领导小文森陈，他成功地领导了PPTNAC在我们正在进行的 UCaMP PDX开发和试用中心(PDTC)，所有现场PI，联系PI和管理核心主管Luis Carvajal-Carmona和UCATS赠款管理人。因此，PPTNAC调查人员反映了多个相关的 促进对包括癌症健康在内的试点研究和跨网络活动进行评价的学科 差异、临床前研究、病理学和基础癌症研究。PPTNAC还将促进互动 具有NCI、PDXNet数据共享和协调中心(PDCCC)、其他PDTC和非 PDXNet调查人员通过资助项目。具体地说，PPTNAC的目标是：(1)促进内部试点 项目；(2)促进跨PDXNet活动(试点研究、发展和评价)；和(3)参与 非网络调查人员；以及(4)使用PDX分享创新技术(与非PDXNet协作 调查人员)。

PILOT PROJECTS AND TRANS-NETWORK ACTIVITIES CORE University of California and UT Southwestern Diversity Patient-Derived Xenograft (PDX) Development and Trial Center (UCaTS) to Reduce Cancer Health Disparities PROJECT SUMMARY/ABSTRACT The goal of the Pilot Projects and Trans-Network Activities Core (PPTNAC) is to contribute to the achievement of the University of Californiaand UT Southwestern Diversity Patient-Derived Xenograft (PDX) Development and Trial Center (UCaTS) overall objectives of developing PDX trial strategies for preclinical testing of single agents and drug combinations. This D-PDTC focuses on the predominant racial/ethnic minority populations residing in California and Texas, namely, Latinos, African American [AAs] and Asian American/Native Hawaiian/Pacific Islander [AANHPIs]. The focus will be on gastric cancer which disproportionately affect Latinos and all populations of color, and lung cancer, which has a high burden in Latino and AANHPI women. Key personnel for this Core include the PPTNAC Lead Moon S. Chen, Jr., who has successfully led PPTNAC in our ongoing UCaMP PDX Development and Trial Center (PDTC), all Site PIs, Contact PI and Administrative Core Lead Luis Carvajal-Carmona, and UCaTS Grant Administrator. As such, PPTNAC investigators reflect multiple relevant disciplines that foster the evaluation of pilot studies and trans-network activities including cancer health disparities, pre-clinical studies, pathology, and basic cancer research. PPTNAC will also facilitate the interaction of UCaTS with NCI, PDXNet Data Commons and Coordinating Centers (PDCCC), other PDTCs, and non- PDXNet investigators through funded projects. Specifically, the PPTNAC Aims are to: (1) Facilitate Internal Pilot Projects; (2) Facilitate Cross-PDXNet Activities (Pilot Studies Development and Evaluation); and (3) Engage Non-Network Investigators; and (4) Share Innovative Technologies using PDXs (Collaboration with non-PDXNet investigators).