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Pilot Projects and Trans-Network Activities

试点项目和跨网络活动

基本信息

批准号：
10733397
负责人：
Moon Shao-Chuang Chen
金额：
$ 0.34万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-01 至 2028-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10733397
关键词：
Achievement Administrator Affect African American Asian Americans Basic Cancer Research California Cancer Model Cancer Patient Cells Collaborations Collection Comprehensive Cancer Center Conduct Clinical Trials Data Commons Decision Making Development Discipline Disparity Doctor of Philosophy Drug Combinations Ensure Evaluation Fostering Funding Goals Grant Health Disparities Research Human Resources International Latino Latino Population Lead Los Angeles Lung Neoplasms Malignant Neoplasms Malignant neoplasm of lung Methods Minority Groups Monitor Moon Native Hawaiian Pacific Islander Pathology Pharmaceutical Preparations Phase Pilot Projects Preclinical Testing Procedures Reproducibility Research Research Personnel San Francisco Site Stomach Neoplasms System Technology Testing Texas Universities Validation Woman Xenograft procedure cancer health disparity chemotherapy community engagement design drug testing efficacy validation ethnic minority ethnic minority population experience innovative technologies malignant stomach neoplasm meetings minority patient novel novel therapeutics patient derived xenograft model people of color pre-clinical precision oncology preclinical study programs racial minority racial minority population repository symposium targeted treatment treatment response tumor

项目摘要

PILOT PROJECTS AND TRANS-NETWORK ACTIVITIES CORE University of California and UT Southwestern Diversity Patient-Derived Xenograft (PDX) Development and Trial Center (UCaTS) to Reduce Cancer Health Disparities PROJECT SUMMARY/ABSTRACT The goal of the Pilot Projects and Trans-Network Activities Core (PPTNAC) is to contribute to the achievement of the University of Californiaand UT Southwestern Diversity Patient-Derived Xenograft (PDX) Development and Trial Center (UCaTS) overall objectives of developing PDX trial strategies for preclinical testing of single agents and drug combinations. This D-PDTC focuses on the predominant racial/ethnic minority populations residing in California and Texas, namely, Latinos, African American [AAs] and Asian American/Native Hawaiian/Pacific Islander [AANHPIs]. The focus will be on gastric cancer which disproportionately affect Latinos and all populations of color, and lung cancer, which has a high burden in Latino and AANHPI women. Key personnel for this Core include the PPTNAC Lead Moon S. Chen, Jr., who has successfully led PPTNAC in our ongoing UCaMP PDX Development and Trial Center (PDTC), all Site PIs, Contact PI and Administrative Core Lead Luis Carvajal-Carmona, and UCaTS Grant Administrator. As such, PPTNAC investigators reflect multiple relevant disciplines that foster the evaluation of pilot studies and trans-network activities including cancer health disparities, pre-clinical studies, pathology, and basic cancer research. PPTNAC will also facilitate the interaction of UCaTS with NCI, PDXNet Data Commons and Coordinating Centers (PDCCC), other PDTCs, and non- PDXNet investigators through funded projects. Specifically, the PPTNAC Aims are to: (1) Facilitate Internal Pilot Projects; (2) Facilitate Cross-PDXNet Activities (Pilot Studies Development and Evaluation); and (3) Engage Non-Network Investigators; and (4) Share Innovative Technologies using PDXs (Collaboration with non-PDXNet investigators).

试点项目和跨网活动的核心