Pilot Projects-Tran-Network

试点项目-跨网

• 批准号: 10733238
• 负责人: Nicolas Skuli
• 金额: $ 3.29万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-05 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10733238
• 关键词: Address; Basic Science; Budgets; Cancer Center; Clinic; Clinical; Collaborations; Common Neoplasm; Communities; Complement; Data; Development; Disabled Persons; Ensure; Equity; Evaluation; Faculty; Financial Support; Fostering; Funding; Goals; Grant; Human Resources; Intervention; Methodology; Monitor; Pennsylvania; Pilot Projects; Process; Progress Reports; Racial Equity; Research; Research Personnel; Resources; Technology; Testing; Tissue Banks; Tissue Expansion; Translational Research; Underrepresented Minority; Universities; Work; cancer health disparity; health care disparity; high risk; innovation; novel; novel strategies; patient derived xenograft model; programs; recruit; research and development; success; tissue resource; tool; translational potential; women with disabilities

Summary: The goals of the Pilot Projects and Trans-Network Activities Core of the UP-PDTC focus on two priorities. First, the Core will promote and support new Pilot Projects with high scientific merit and innovation that will strongly impact PDX model development research and/or have the potential for translation to the clinic. The Core will specifically act as a focal point and resource to bring new ideas, technologies, interventions, and researchers into the UP-PDTC and the PDXNet. Second, the Pilot Projects and Trans-Network Core will prioritize and facilitate novel projects that can add to the translational capabilities of the PDXNet. Key criteria for project selection will include 1) high expected impact; 2) translational potential that may eventually be integrated into full projects within the UP-PDTC or PDXNet; 3) innovative ideas and approaches that generate new hypotheses and preliminary data; 4) collaborations to develop novel research and research tools, 5) high risk/high return projects that move basic science and/or clinical interventions and 6) development of tissue collections that address cancer disparities. Although the UP-PDTC will be a T-PDTC, we acknowledge and highly support the latter goal. Pilot project grants will be competitively financially supported by the Core budget and the PDX Core personnel will work with Pilot Project PI’s to develop application to the TransNetwork program and/or for specific R01 applications. Solicitations for Core projects are made within the University of Pennsylvania Abramson Cancer Center. Specific efforts will be made to recruit Pilot Project applicants from underrepresented minorities (URM), women, and individuals with disabilities. The UP-PDTC Administrative Core will assist in implementing a coordinated process for review, selection, and monitoring Pilot Projects, ensuring that UP-PDTC resources are used effectively to expand PDX modeling, interactions with the PDXNet and PDXNet research. The influx of research from new PDX modelers and investigators, or from those with expertise outside of the most common tumors, will foster innovative new directions and complement ongoing efforts in the UP-PDTC and PDXNet.

总结： UP-PDTC的试点项目和跨网络活动核心的目标侧重于两个优先事项。 首先，核心将促进和支持具有高度科学价值和创新的新试点项目， 强烈影响PDX模型开发研究和/或具有转化为临床的潜力。的 核心将专门作为一个协调中心和资源，带来新的想法，技术，干预措施， UP-PDTC和PDXNet的研究人员。第二，试验项目和跨网络核心将 优先考虑和促进新的项目，可以增加PDXNet的翻译能力。关键标准 项目选择将包括1）高预期影响; 2）最终可能被 整合到UP-PDTC或PDXNet内的完整项目中; 3）创新的想法和方法， 新的假设和初步数据; 4）合作开发新的研究和研究工具，5）高 风险/高回报项目，推动基础科学和/或临床干预，以及6）组织开发 解决癌症差异的集合。虽然UP-PDTC将是T-PDTC，但我们承认， 我非常支持后一个目标。试点项目赠款将由核心预算竞争性地提供资金支持 PDX核心人员将与试点项目PI合作开发TransNetwork应用程序 程序和/或特定的R 01应用程序。核心项目的招标是在大学内进行的。 宾夕法尼亚艾布拉姆森癌症中心我们将特别努力从以下方面招募试点项目申请人： 代表性不足的少数民族（URM），妇女和残疾人。UP-PDTC行政 核心小组将协助实施一个协调一致的进程，以审查、选择和监测试点项目， 确保UP-PDTC资源有效地用于扩展PDX建模、与PDXNet的交互 PDXNet研究来自新的PDX建模者和研究者的研究，或者来自那些 最常见的肿瘤之外的专业知识，将促进创新的新方向，并补充正在进行的 在UP-PDTC和PDXNet中的努力。