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Chronic graft-versus-host disease

Chronic graft-versus-host disease
慢性移植物抗宿主病
批准号：
10014723
负责人：
Edward Cowen
金额：
$132.61万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10014723
关键词：
CalcinosisCase SeriesClinicalClinical TrialsCutaneousFunctional disorderImatinibInstitutesOutputPublicationsResearch PersonnelRisk FactorsRoleSkinSkin ManifestationsSpecialistSpecimenUnited States National Institutes of HealthWhole-Body Irradiationchronic graft versus host diseasemultidisciplinarynovelskin disorder

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中文摘要
翻译
这一努力继续卓有成效，与GVHD有关的年度出版产出，包括分支机构发起的伊马替尼临床试验的出版，证明了这一点。此外，我在cGVHD新的皮肤表现的识别方面做出了一些重要贡献，以及确认全身照射作为cGVHD的危险因素所起的作用。目前的项目包括对皮肤GVHD样本进行单链RNA分析，以更好地了解皮肤病的病理生理学。临床项目包括首个针对皮肤移植物抗宿主病的鲁索利替尼的局部研究，以及皮肤移植物抗宿主病皮肤钙质沉着症的病例系列。
英文摘要
This effort continues to be very productive as evidenced by the yearly publication output related to GVHD, including publication of the Branch initiated imatinib clinical trial. In addition, I have made several important contributions to the identification of novel skin manifestations of cGVHD, as well as identified the role of total body irradiation as a risk factor for cGVHD. Current projects including ssRNA analysis of cutaneous GVHD specimens to better understand the pathophysiology of skin disease. Clinical projects including the first topical study of ruxolitinib for skin GVHD and a case series on cutaneous calcinosis in skin GVHD.
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