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Anakinra for neutrophilic pustular skin disease

Anakinra for neutrophilic pustular skin disease
阿那白滞素（Anakinra）治疗中性粒细胞性脓疱性皮肤病
批准号：
10486881
负责人：
Edward Cowen
金额：
$9.64万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10486881
关键词：
BiologicalBiological MarkersClinicalClinical TrialsCollaborationsDataDiseaseDoseGeneralized pustular psoriasisGeneticImageInflammatoryInterleukin-1LaboratoriesManuscriptsPathway interactionsPatient Outcomes AssessmentsPatientsProtocols documentationPublicationsPustular psoriasisTherapeuticanakinraclinical outcome measuresdesignefficacy evaluationneutrophilnovelrecruitskin disordervascular inflammation

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中文摘要
翻译
本议定书不接受招募，将于2021年7月提交出版。该手稿总结了临床试验结果、遗传数据、组织病理学相关性、全身炎症生物标志物、血管炎症成像、患者报告的结果和试验中采用的新的临床结果测量方法。简而言之，阿那金在局部和广泛性脓疱性银屑病中显示出有效的剂量递增方法，使用阿那金每日剂量高达3mg sc。
英文摘要
This protocol is closed to recruitment and will be submitted for publication in July 2021. The manuscript summarizes the clinical trial results, genetic data, histopathologic correlaton, systemic inflammatory biomarkers, vascular inflammation imaging, patient reported outcomes and novel clinical outcome measures that were employed in the trial. Briefly, anakinra showed efficacy in both local and generalized pustular psoriasis in a dose escalation approach using dosing of anakinra of up to 3mg sc daily.
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Anakinra for neutrophilic pustular skin disease
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