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Chronic graft-versus-host disease

Chronic graft-versus-host disease
慢性移植物抗宿主病
批准号：
10697705
负责人：
Edward Cowen
金额：
$35.63万
依托单位：
NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10697705
关键词：
Annual ReportsBibliographyBiological MarkersBiologyBiopsyClinicalCollaborationsDevelopmentGuidelinesHematologyImmunologicsInternationalLungManuscriptsMeasuresPaperPatientsPhenotypePublishingRehabilitation therapyRelapseSecond Primary NeoplasmsSkinSpecimenTechnologyUnited States National Institutes of Healthchronic graft versus host diseasemontelukastphase II trialtranscriptome sequencing

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中文摘要
翻译
该项目是一个长期的临床合作项目，是NIH大型内部努力的一部分，旨在推进慢性移植物抗宿主病的研究和治疗。使用临床标本（皮肤活检）以及广泛表型的患者材料，我们的目标是在该领域取得重要进展。这导致自上一份年度报告以来出版了几份手稿。去年的进展包括对皮肤硬化型GVHD患者康复措施的全面审查，NIH国际联盟关于硬化性GVHD的指南，孟鲁司特治疗肺GVHD的II期试验，GVHD的生物标志物，血液学复发的预测因子，以及GVHD发展后的第二次恶性肿瘤的预测因子。
英文摘要
This project is a long-term clinical collaboration as part of a large intramural NIH effort to advance the study and treatments of chronic graft-versus-host disease. Using clinical specimens (skin biopsies) as well as extensively phenotyped patient material, we aim to make important advances in the field. This has led to several published manuscripts since the last Annual Report. Advances in the last year include a comprehensive review of rehabilitative measures for patients with sclerotic-type GVHD of the skin, NIH International Consortium Guidelines on sclerotic GVHD, a Phase II trial of montelukast for pulmonary GVHD, biomarkers in GVHD, and predictors of hematologic relapse, and predictors of second malignancy after the development of GVHD.
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