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Chronic graft-versus-host disease

Chronic graft-versus-host disease
慢性移植物抗宿主病
批准号：
10697705
负责人：
Edward Cowen
金额：
$35.63万
依托单位：
NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10697705
关键词：
Annual ReportsBibliographyBiological MarkersBiologyBiopsyClinicalCollaborationsDevelopmentGuidelinesHematologyImmunologicsInternationalLungManuscriptsMeasuresPaperPatientsPhenotypePublishingRehabilitation therapyRelapseSecond Primary NeoplasmsSkinSpecimenTechnologyUnited States National Institutes of Healthchronic graft versus host diseasemontelukastphase II trialtranscriptome sequencing

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中文摘要
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英文摘要
This project is a long-term clinical collaboration as part of a large intramural NIH effort to advance the study and treatments of chronic graft-versus-host disease. Using clinical specimens (skin biopsies) as well as extensively phenotyped patient material, we aim to make important advances in the field. This has led to several published manuscripts since the last Annual Report. Advances in the last year include a comprehensive review of rehabilitative measures for patients with sclerotic-type GVHD of the skin, NIH International Consortium Guidelines on sclerotic GVHD, a Phase II trial of montelukast for pulmonary GVHD, biomarkers in GVHD, and predictors of hematologic relapse, and predictors of second malignancy after the development of GVHD.
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