Oklahoma Rheumatic Disease Research Cores Center (Overall Application)

俄克拉荷马州风湿病研究核心中心（整体申请）

• 批准号: 10016168
• 负责人: JUDITH A JAMES
• 金额: $ 87.4万
• 依托单位: OKLAHOMA MEDICAL RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-07 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10016168
• 关键词: Aging; Applications Grants; Autoimmune Process; Autoimmunity; Basic Science; Biological Assay; Biological Markers; Biomedical Engineering; Brain; Cells; Clinical; Clinical Management; Clinical Research; Clinical Trials; Clinical Trials Design; Collaborations; Collection; Communication; Complex; Connective Tissue Diseases; Consult; Cytometry; Data; Data Set; Degenerative polyarthritis; Development; Diagnosis; Diagnostic; Disease; Distant; Evaluation; Flow Cytometry; Foundations; Future; Genus Capra; Goals; Health; Human; Human Resources; Immune response; Immunologic Monitoring; Indigenous; Inflammatory; Informatics; Information Systems; Infrastructure; Institutes; Institution; International; Investigation; Investments; Leadership; Literature; Lupus; Manuscripts; Medicine; Mentors; Methodology; Mission; Modeling; Molecular; Monitor; NCI Scholars Program; National Institute of Allergy and Infectious Disease; Oklahoma; Pathogenesis; Pathologic; Patient Selection; Patient-Focused Outcomes; Patients; Phenotype; Pilot Projects; Precision therapeutics; Pregnancy; Preparation; Prevalence; Prevention; Prevention trial; Procedures; Proteomics; Public Health; Research; Research Design; Research Infrastructure; Research Personnel; Resources; Rheumatism; Rheumatoid Arthritis; Rheumatology; Sampling; Scientist; Seasons; Services; Sjogren' s Syndrome; Study Subject; Symptoms; System; Systemic Lupus Erythematosus; Technology; Testing; Training; Undifferentiated; United States National Institutes of Health; Work; assay development; base; biobank; career; clinical care; cost; data access; data warehouse; disease classification; experience; high dimensionality; inter-institutional; molecular phenotype; multidimensional data; multidisciplinary; outcome forecast; patient subsets; phenotypic data; precision medicine; prognostic; programs; recruit; response; sample collection; systems research; therapeutic target; transcriptomics

Oklahoma Rheumatic Disease Research Cores Center: Overall Project Summary The Oklahoma Rheumatic Disease Research Cores Center (ORDRCC) unites 25 established Center Investigators, 22 junior center investigators (11 within and 11 outside Oklahoma) and a newly proposed Reichlin/Capra Scholar program to develop early-stage investigators with outstanding promise in rheumatic disease research. The mission of the ORDRCC is to optimize interactions between basic, clinical and analytic scientists focused on deciphering pathogenesis, prediction, prevention and precision therapeutic selection in rheumatic disease. As the foundation for this mission, the ORDRCC has developed some of the largest existing cross-sectional and longitudinal collections of SLE, Sjogren’s, and rheumatoid arthritis. With a CAP- certified Biorepository and electronic clinical research management system, the ORDRCC continues to expand these large, well-characterized collections and to build others in osteoarthritis, undifferentiated connective tissue disease and autoimmune rheumatic disease pregnancies. The ORDRCC-supported collections and biorepository infrastructure are critical resources for many established rheumatic disease investigators and inter-institutional rheumatic disease collaborations, and have helped launch the independent careers of 27 former New Investigators. Without ORDRCC support, these collections would be unavailable, as would the basic infrastructure that enables the Biorepository to serve several NIH-sponsored and other investigator- initiated clinical trials at a fraction of the cost of a commercial biorepository. The Clinical Characterization and Biorepository Core (CCBC) which houses these collections, also provides clinical research units to aid in study recruitment, regulatory assistance for junior investigators and Scholars, and translational informatics to help visualize complex datasets of clinical and molecular data. The newly revised Human Phenotyping Core (HPC) empowers ORDRCC investigators to use the latest high-content phenotyping methodologies for precision medicine approaches by providing experienced technical personnel, proven standard operating procedures and training for sample preparation, assay development, data QC, and analytical assistance. The HPC helps ORDRCC investigators perform and analyze high-dimensional cytometry, single-cell transcriptomics and proteomics, high-content flow cytometry for functional immune response assays, molecular phenotyping by transcriptomics, and high-throughput testing of soluble biomarkers. Together the CCBC and HPC will integrate clinical and molecular information to identify molecularly homogeneous subsets of subjects for studies or trials. The Administrative Core serves as the central management and communication hub for the ORDRCC and coordinates a multi-disciplinary enrichment program, including a Rheumatic Disease Research Forum, a vibrant and successful Pilot Projects program, a new Proposal Development Core to assist investigators with developing robust manuscripts and competitive grant applications and a new Expanding Rheumatic Disease Research Colloquium to forge interactions between ORDRCC scientists and investigators from other fields.

俄克拉荷马州风湿病研究核心中心：总体项目摘要 俄克拉荷马州风湿病研究核心中心（ORDRCC）单位25已建立的中心 调查人员，22名初级中心调查人员（俄克拉荷马州以外的11人）和一个新提议 Reichlin/Capra Scholar计划，旨在培养早期阶段的调查员 疾病研究。 ORDRCC的任务是优化基本，临床和分析之间的相互作用 科学家专注于破译发病机理，预测，预防和精确治疗选择 风湿病。作为这项任务的基础，ORDRCC开发了一些最大的 SLE，Sjogren和类风湿关节炎的现有横截面和纵向收集。带有帽子 ORDRCC认证的Biorepository和电子临床研究管理系统，继续扩展 这些大型，良好的收藏品，并在骨关节炎，未分化的结缔组织中建造其他收藏 组织疾病和自身免疫性风湿病妊娠。 ORDRCC支持的收藏和 对于许多已建立的风湿病研究者和 机构间风湿病的合作，并帮助启动了27个独立职业 前新调查员。如果没有ORDRCC的支持，这些收藏将是不可用的， 基本基础设施使生物座位能够为NIH赞助和其他研究人员提供服务 - 以商业生物座位的成本的一小部分开始了临床试验。临床表征和 包含这些收藏品的生物座核（CCBC）也提供临床研究单位以帮助研究 招聘，初级调查人员和学者的监管援助，并翻译信息以帮助 可视化临床和分子数据的复杂数据集。新修订的人类表型核心（HPC） 授权ORDRCC调查人员使用最新的高含量表型方法进行精确 医学方法通过提供经验丰富的技术人员，证明标准操作程序 以及用于样本制备，评估开发，数据质量控制和分析援助的培训。 HPC有帮助 ORDRCC研究人员执行和分析高维细胞仪，单细胞转录组学和 蛋白质组学，用于功能免疫反应测定的高含量流式细胞仪，分子表型 转录组学和固体生物标志物的高通量测试。 CCBC和HPC一起集成 临床和分子信息，以鉴定研究或试验的受试者的分子均匀子集。 行政核心是ORDRCC和 协调一个多学科的丰富计划，包括风湿病研究论坛，一个 充满活力和成功的飞行员项目计划，这是一种新的提案开发核心，旨在协助调查人员 开发强大的手稿和竞争性赠款应用以及一种新的扩展风湿病 研究座谈会，以实现其他领域的ORDRCC科学家和研究人员之间的相互作用。