Administrative Core

ORDRCC行政核心项目摘要 俄克拉荷马州风湿病研究核心中心(ORDRCC)促进风湿病合作 疾病研究，提供尖端技术来解决与临床相关的新问题，招募 对风湿病调查有其他兴趣/培训的调查人员并促进青少年的发展 研究人员要独立从事风湿病的研究事业。有25名当地中心调查人员，11名初级 中心调查员(当地)、11名初级中心调查员(远程)和一个新的学者方案将制定 致力于风湿病调查的早期调查人员，ORDRCC行政核心 作为完成扩展ORDRCC的中央通信枢纽和信息管道 使命为每个研究患者提供详细的、个性化的信息，以便研究人员选择 同质的、机械驱动的患者亚群，用于研究发病机制、预测、预防和 精准治疗系统性红斑狼疮、干燥、UCTD及相关疾病。ORDRCC将促进职业生涯 发展初级研究人员，多管齐下扩大风湿病研究 风湿病临床研究丰富计划，包括每周一次的研讨会系列，访问 讲座，以及与一个新的小组联合举行的新的风湿病研讨会 季度探索合作研究的新领域，例如与俄亥俄大学雷诺老龄化中心 生物工程、麦基院长眼科研究所等。对社区的额外外展沟通- 还计划开展以合作伙伴和部落社区为基础的项目。行政核心将加强沟通 通过新的在线资源、列表服务和更新；通过制定的策略和 监督和优化资源利用的程序，优先为初级中心服务 调查人员和学者；并在行政核心内建立一个新的提案开发中心，以 帮助青少年中心调查人员和学者准备和提交稿件和竞争助学金 申请。核心中心还协助初级中心调查人员和学者遵守法规 疏忽。ORDRCC有一个历史上充满活力的试点项目计划，该计划启动了独立的 16名初级调查员的职业生涯，他们后来获得了超过2000万美元的独立外部赠款 支持。本核心将继续提供这一计划，将适度的财政支持与优先考虑的计划结合起来 核心资源、重点指导和职业发展计划。行政核心还作为 与咨询委员会互动以确保对建议进行审查和 实施。ORDRCC实施了严格的定性和定量跟踪和评估 计划评估，帮助监控和最大化资源利用和科学发现。这些 定性调查还有助于设定战略中心的优先事项，确定表型服务和新的 评估和识别需要扩展或进一步增强的患者集合的技术。

ORDRCC Administrative Core Project Summary The Oklahoma Rheumatic Disease Research Cores Center (ORDRCC) facilitates collaborative rheumatic disease research, provides cutting-edge technologies to address new clinically-relevant questions, recruits investigators with other interests/training to rheumatic disease investigation and fosters development of junior investigators to independent rheumatic disease research careers. With 25 local Center Investigators, 11 Junior Center Investigators (local), 11 Junior Center Investigators (distant) and a new Scholar program to develop early stage investigators committed to rheumatic disease investigation, the ORDRCC Administrative Core serves as the central communications hub and information conduit to accomplish the expanded ORDRCC mission to provide detailed, individualized information for each study patient to allow investigators to select homogeneous, mechanistic-driven subsets of patients for studies of pathogenesis, prediction, prevention and precision treatment of SLE, Sjogren’s, UCTD and related disorders. The ORDRCC will enhance the career development of junior investigators and expand rheumatic disease research through a multi-pronged Rheumatic Disease Clinical Research Enrichment Program which includes a weekly seminar series, visiting lectureships, and a new Expanding Rheumatic Disease Colloquium held in conjunction with a new group each quarter to explore new areas of collaborative research, such as with the Reynolds Center on Aging, OU Bioengineering, Dean McGee Eye Institute, and others. Additional outreach communication to community- based partners and tribal communities is also planned. The Administrative Core will enhance communication through new online resources, listserves and updates; provide management through developed policies and procedures for oversight and optimization of resource utilization, prioritizing service to junior center investigators and Scholars; and develop a new Proposal Development Center within the Administrative Core to help junior center investigators and Scholars to prepare and submit manuscripts and competitive grant applications. The Core also assists Junior Center Investigators and Scholars with regulatory compliance oversight. The ORDRCC has a historically vibrant pilot project program which has launched the independent careers of 16 junior investigators who have gone on to receive over $20M in independent external grant support. This Core will continue to offer this program which couples modest financial support with prioritized Core resources, focused mentoring and a career development plan. The Administrative Core also serves as the nidus for interactions with the Advisory Committee to ensure that suggestions are reviewed and implemented. The ORDRCC has implemented a rigorous qualitative and quantitative tracking and evaluation program evaluation which helps to monitor and maximize resource utilization and scientific discoveries. These qualitative surveys also help to set strategic Center priorities, prioritize phenotyping services and new technologies to evaluate and identify the patient collections which need expansion or further enhancement.