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CF 1: Biospecimen Repository Core

CF 1：生物样本存储库核心

基本信息

批准号：
10016092
负责人：
CRISTINA R ANTONESCU
金额：
$ 17.38万
依托单位：
SLOAN-KETTERING INST CAN RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-01 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10016092
关键词：
Animal Model Animals Apoptosis Applied Research Archives Basic Science Bioinformatics Biological Assay Biological Specimen Banks Blood Cancer Center Cell Line Cell Survival Center Core Grants Clinical Clinical Research Clinical Trials Collaborations Collection Core Facility Custom DNA Data Databases Diagnosis Enrollment Ensure Evaluation Fibrosis Fluorescent in Situ Hybridization Formalin Freezing Generations Genes Human Image Individual Induction of Apoptosis Infrastructure Institutional Review Boards Memorial Sloan-Kettering Cancer Center Microscopic Molecular Morphology Mus Mutation Necrosis Normal Cell Normal tissue morphology Nucleic Acids Oncogenes Paraffin Embedding Pathologic Pathology Patients Pharmaceutical Preparations Pharmacotherapy Phosphorylation Phosphotransferases Pilot Projects Plasma Play Protocols documentation Research Research Personnel Research Project Grants Resources Role Sampling Scanning Services Soft Tissue Neoplasms Soft tissue sarcoma Techniques Testing Tissue Embedding Tissue Microarray Tissue Sample Tissues Translational Research Xenograft Model Xenograft procedure central database cost effective design digital human tissue immunohistochemical markers mouse model mutation screening peripheral blood programs response sarcoma targeted sequencing tumor

项目摘要

CF-1: Biospecimen Repository ABSTRACT The Biospecimen Repository Core (CF-1) is designed to provide support to the basic and translational research efforts of the SPORE. The CF-1 will play a central role in collecting, annotating, storing, distributing, and tracking of tissue and blood biospecimens from patients enrolled in research protocols. The Core will provide SPORE investigators with expert histopathological evaluation of tumor samples both from patients enrolled on research protocols and from murine and xenograft models. Additionally it will assist in selecting appropriate formalin-fixed, paraffin-embedded tissue and snap-frozen tissue for research and pilot projects, as well as enable the creation of tissue microarrays (TMAs) for SPORE investigator studies. The Core will provide assistance in performing and interpreting immunohistochemical studies and fluorescence in situ hybridization (FISH) assays. It will provide scanning and digital archiving of TMA images and reliable interpretation, scoring, and archiving of IHC results from frozen, paraffin-embedded sections or TMA sections. The core will also provide systematic assessment of tumor response to therapy in human tissues and in sarcoma murine models, including interpretation of immunohistochemical markers for drug response, such as changes in kinase phosphorylation, proliferation inhibition, and induction of apoptosis. It also provides a centralized resource for mutational annotation of sarcoma samples and cell lines using the IMPACT platform. Finally, it ensures linkage to the clinical sarcoma database in collaboration with project leaders, the bioinformatics core (CF-2 Qin/Socci) and the administrative core (Singer). This establishes a substantial infrastructure and allows us to provide the required services in a cost-effective manner. The CF-1 is tightly integrated with the MSKCC Institutional Pathology Core (supported by the MSKCC Cancer Center Core Grant) and the Clinical Research Database (CRDB) managed by the administrative core.

CF-1：生物标本库