C1 - Biospecimen Repository Core

生物膜生物信息库核心(CF-A)的设计目的是为基础跨学科研究提供支持 孢子的努力。核心将在收集、注释、存储、分发和 追踪登记在研究方案中的患者的肉瘤和正常组织血液病。四个关键 肉瘤孢子生物质谱库的重点领域是高质量的储存库(冷冻和 石蜡包埋)和血液(血清和血浆)；准确和最新的程序、病理和 临床注释；在研究方案中使用的布洛西莫的有效和有效的分布；以及 强大的跟踪系统，能够通过利用从收集到的水华监测水华。集成 这四个组成部分是生态库核心的一个主要目标。 核心将为孢子赋形者提供肿瘤样本的专家组织病理学评估，两者 从研究方案登记的患者，从小鼠和异种移植模型。核心将提供 协助执行和解释免疫组织化学研究，选择问题 微解剖和构建阵列，并与项目负责人和CF-B合作。核心将会 还提供了对人体组织和动物模型中肿瘤治疗反应的系统评估 肉瘤，包括对药物反应的免疫组织化学标志物的解释，例如 激酶磷酸化，抑制细胞增殖，诱导细胞凋亡。核心将提供 根据个别研究项目的需要，对肉瘤肿瘤和细胞系进行突变注释。

The Biospecimen Repository Core (CF-A) is designed to provide support to the basic translafional research efforts of the SPORE. The Core will play a central role in collecfing, annotafing, storing, distribufing, and tracking sarcoma and normal tissue blospecimens from pafients enrolled in research protocols. The four key focus areas forthe sarcoma SPORE Biospecimen Repository are high quality banked fissue (frozen and paraffin-embedded) and blood (serum and plasma); accurate and updated procedural, pathologic, and clinical annotafion; efficient and effective distribufion of blospecimens for use in research protocols; and a robust tracking system capable of monitoring blospecimens from collecfion through utilization. Integrating these four components is a major goal of the Biospecimen Repository Core. The Core will provide SPORE invesfigators with expert histopathologic evaluation of tumor samples, both from pafients enrolled on research protocols and from murine and xenograft models. The Core will provide assistance in performing and interprefing immunohistochemical studies, in selecfing fissue for microdissecfion and construcfion of arrays, and in collaborating with project leaders and CF-B. The core will also provide systematic assessment of tumor response to therapy in human tissues and in animal models of sarcomas, including interpretafion of immunohistochemical markers for drug response, such as changes in kinase phosphorylafion, inhibifion of proliferafion, and inducfion of apoptosis. The Core will provide mutafional annotafion for sarcoma tumors and cell lines, as needed by individual research projects.