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Structure and function of the mouse parafasicular and entopeduncular nuclei

小鼠束旁核和足内核的结构和功能

基本信息

批准号：
10023565
负责人：
Pavel Osten
金额：
$ 16.95万
依托单位：
HARVARD MEDICAL SCHOOL
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-07-01 至 2020-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10023565
关键词：
Address Adopted Anatomy Animals Attention Axon Basal Ganglia Behavior Behavioral Behavioral Paradigm Brain Brain Stem Cell Nucleus Cells Centromedian Thalamic Nucleus Corpus striatum structure Data Disease Dorsal Drug Addiction Drug effect disorder Eating Electrophysiology (science)Elements Environment Evaluation Food Future Genetic Gilles de la Tourette syndrome Globus Pallidus Glutamates Goals Habenula Head Huntington Disease Individual Intralaminar Nuclear Group Lateral Left Literature Locomotion Maps Mediating Midbrain structure Modeling Molecular Molecular Profiling Motor Movement Mus Neurons Obsessive-Compulsive Disorder Outcome Output Parafascicular Nucleus Parkinson Disease Pathogenesis Pathway interactions Pattern Primates Process Property Psychological reinforcement Rewards Rodent Sensory Signal Transduction Stereotyping Structure Substantia nigra structure Thalamic Nuclei Thalamic structure Training Viral Work base behavioral study cell type drug of abuse endopeduncular nucleus environmental change experience flexibility gamma-Aminobutyric Acid in vivo motivated behavior neuropsychiatric disorder novel preference relating to nervous system sensory stimulus tool

项目摘要

Project Summary On a moment-by-moment basis each animal must consider its environment, past experience, and present goals to choose future actions. For example, presented with food a hungry animal will likely eat, although not if a predator is near or if the context in which the food appears was previously associated with an adverse output. The process of action selection depends on the proper function of the basal ganglia (BG). Perturbations of BG contribute to many diseases including Parkinson's, Huntington's, Tourette's, and obsessive-compulsive disorders as well as to drug addiction. How activity in the BG mediates action selection and reinforces the repetition of actions associated with positive outcomes is still unknown. Work from a variety of species, indicates that the entopeduncular (EP) and parafascicular (PF) nuclei are important for these processes and contribution to action outcome evaluation and action selection, respectively. Here we propose to carry out anatomical, functional, and behavioral studies in mice to understand the circuitry of these nuclei and how their activity contributes to action selection and evaluation. We make use of new tools and behavioral paradigms to address these unknowns and use anatomical studies to guide our in vivo analyses.

项目总结