Central circuitry controlling micturition

项目概要 尿液的释放，称为排尿，是一个严格控制的过程。排尿是 维持水盐平衡所必需的重要生理功能， 以及从血液中排出不需要的分子。然而，在许多动物的尿液中 也在特定的地方发布，以便与同一组的其他成员进行交流 避免在其他地方释放该物种，以避免被捕食者发现。 从“脑桥排尿中心”（PMC）到脊髓的下降投影 在小鼠和人类中保守并触发尿液释放。 PMC 接收输入 来自许多高级大脑中心并整合来自这些中心的信息来控制 排尿。因此，在许多神经精神疾病中， 排尿受到影响，导致尿失禁、尿潴留或 在不适宜社交的时间和地点自愿排尿。在这里我们建议 绘制和研究小鼠的这些通路，以了解其背后的电路 排尿的中枢控制。

Project Summary The release of urine, known as micturition, is a tightly controlled process. Micturition is an important physiological function necessary to maintain water and salt balance, as well as to expel unwanted molecules from the blood. However, in many animals urine is also released in specific places to communicate with other members of the same species and its release is avoided in other places to avoid detection by predators. Descending projections from the “pontine micturition center” (PMC) to the spinal cord are conserved in mice and humans and trigger urine release. The PMC receives inputs from many higher brain centers and integrates information from these to control micturition. For this reason, in many neuropsychiatric diseases the central control of micturition is compromised resulting in urine incontinence, urine retention, or the volitional release of urine at socially inappropriate times and places. Here we propose to map and study these pathways in mice to understand how circuits that underlie central control of micturition.