Central circuitry controlling micturition

项目摘要 尿液的释放，即所谓的排尿，是一个严格受控的过程。排尿是 维持水盐平衡所必需的重要生理功能，如 以及从血液中排出不需要的分子。然而，在许多动物中，尿液 也是在特定的地方发布，与其他相同的成员进行交流 物种及其释放在其他地方是避免的，以避免被捕食者发现。 脑桥排尿中心(PMC)向脊髓的下行投射 在小鼠和人类体内保守，并引发尿液释放。PMC接收输入 来自许多高级大脑中心，并整合来自这些中心的信息来控制 排尿。因此，在许多神经精神疾病中，中枢控制 排尿功能受损，导致尿失禁、尿潴留或 在不适宜社交的时间和地点随意排尿。在这里，我们建议 在小鼠身上绘制和研究这些通路，以了解这些回路是如何构成的 排尿的中央控制。

Project Summary The release of urine, known as micturition, is a tightly controlled process. Micturition is an important physiological function necessary to maintain water and salt balance, as well as to expel unwanted molecules from the blood. However, in many animals urine is also released in specific places to communicate with other members of the same species and its release is avoided in other places to avoid detection by predators. Descending projections from the “pontine micturition center” (PMC) to the spinal cord are conserved in mice and humans and trigger urine release. The PMC receives inputs from many higher brain centers and integrates information from these to control micturition. For this reason, in many neuropsychiatric diseases the central control of micturition is compromised resulting in urine incontinence, urine retention, or the volitional release of urine at socially inappropriate times and places. Here we propose to map and study these pathways in mice to understand how circuits that underlie central control of micturition.