Central circuitry controlling micturition

项目摘要 尿液的释放，称为排尿，是一个严格控制的过程。排尿 维持水盐平衡所必需的重要生理功能，如 也可以排出血液中不需要的分子。然而，在许多动物中， 也在特定的地方释放，以与同一个组织的其他成员进行交流。 在其他地方避免放生，以免被捕食者发现。 从“脑桥排尿中心”（PMC）到脊髓的下行投射 在小鼠和人类中是保守的，并触发尿液释放。PMC接收输入 从许多更高的大脑中心，并整合这些信息，以控制 排尿因此，在许多神经精神疾病中， 排尿受到损害，导致尿失禁、尿潴留或 在社交场合不合适的时间和地点故意释放尿液。在这里我们建议 绘制并研究老鼠的这些通路， 排尿的中枢控制

Project Summary The release of urine, known as micturition, is a tightly controlled process. Micturition is an important physiological function necessary to maintain water and salt balance, as well as to expel unwanted molecules from the blood. However, in many animals urine is also released in specific places to communicate with other members of the same species and its release is avoided in other places to avoid detection by predators. Descending projections from the “pontine micturition center” (PMC) to the spinal cord are conserved in mice and humans and trigger urine release. The PMC receives inputs from many higher brain centers and integrates information from these to control micturition. For this reason, in many neuropsychiatric diseases the central control of micturition is compromised resulting in urine incontinence, urine retention, or the volitional release of urine at socially inappropriate times and places. Here we propose to map and study these pathways in mice to understand how circuits that underlie central control of micturition.