Conduct of studies to evaluate the toxicity of trimethylsilyldiazomethane in laboratory animals for the National Toxicology Program (NTP)

该项目的目标是为国家毒理学计划（NTP）的危害识别活动提供支持，这些活动旨在预防因环境暴露于化学或物理制剂而引起的疾病或不良影响。毒性测试是公共卫生研究的一个重要方面，因为它有助于确定对人类健康有害的化学品。需要适当进行毒理学研究，以确保所得数据可靠。本项目涉及三甲基硅基重氮甲烷（TMSD）的急性毒性表征。TMSD是一种用于合成化学的甲基化剂。它作为重氮甲烷的安全替代品销售，主要是由于爆炸潜力较低。然而，两名化学家在实验室使用TMSD时死于急性肺水肿。NTP正在进行毒性研究，以进一步检查TMSD诱导肺毒性的可能性。 该项目的数据将用于制定关于TMSD在大鼠和小鼠中的潜在毒性和致癌性的合理科学结论，并最终支持国家毒理学计划和其他联邦机构的风险评估工作。此外，市民亦可充分了解接触TMSD所引致的风险因素。 关键词：毒性，吸入，三甲基硅基重氮甲烷，肺

The goal of this project is to provide support of National Toxicology Program (NTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper conduct of toxicology studies is required to ensure that the resulting data are reliable. This project involves the characterization of the acute toxicity of trimethylsilyldiazomethane (TMSD). TMSD is a methylating agent used in synthetic chemistry. It is marketed as a safe replacement for diazomethane, primarily due to a lower explosive potential. However, two chemists died of acute pulmonary edema while working with TMSD in the laboratory. NTP is performing toxicity studies in order to further examine the potential for TMSD to induce pulmonary toxicity. The data from this project will be used in the development of sound, scientific conclusions about the potential toxicity and carcinogenicity of TMSD in rats and mice and ultimately supports the risk assessment efforts of National Toxicology Program and other federal agencies. In addition, the public can be adequately informed about risk factors arising from exposure to TMSD. Keywords: toxicity, inhalation, trimethylsilyldiazomethane, lung