Infrastructure and Core Activities of the Social Science Genetic Association Consortium
社会科学遗传学协会联盟的基础设施和核心活动
基本信息
- 批准号:10020309
- 负责人:
- 金额:$ 34.78万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-15 至 2020-09-30
- 项目状态:已结题
- 来源:
- 关键词:AdolescentAdultAgingAreaBehaviorBehavioralCatalogsCollectionCommunitiesComputer softwareDataData SetDevelopmentDietary intakeDocumentationFollow-Up StudiesFundingGeneticGenomicsGenotypeGoalsGrantHealthHealth and Retirement StudyInfrastructureLifeLongitudinal StudiesManualsMeasuresMeta-AnalysisMethodologyMethodsMonoclonal Antibody R24National Institute on AgingPhenotypePoliciesPublishingResearchResearch PersonnelResourcesRiskSamplingScience of geneticsSocial FunctioningSocial SciencesTargeted ResearchUpdateWisconsinbehavioral genomicsbehavioral phenotypingbehavioral studybehavioral/social scienceexperiencegenetic associationgenetic predictorsgenome wide association studygenome-wideinterdisciplinary collaborationonline resourcerepositoryresponsesatisfactionsocialstatisticstooluser friendly softwareuser-friendlyweb site
项目摘要
The Social Science Genetic Association Consortium (SSGAC) is a research network that provides a platform for
large-scale, interdisciplinary collaborations on genome-wide association studies of behavioral phenotypes.
Because credible results often require large discovery samples, a primary function of the SSGAC is to conduct
genome-wide association studies conducted in different datasets and then rigorously combine the results. To this
end, the SSGAC also promotes the collection of harmonized and well-measured phenotypes across datasets and
the development of new methodological tools. The SSGAC is committed to disseminating its research findings,
as well as accompanying software and manuals, to the research community.
The overarching goal of this proposal is to maintain and develop the core infrastructure of the SSGAC. The
resources produced by the SSGAC will continue to serve the field of behavioral genomics in general, and the
behavioral genomics of aging in particular. The Specific Aims are:
• Conduct genome-wide association studies of health and aging-relevant behavioral phenotypes in much larger
samples that have now become available. Currently planned studies include analyses of educational
attainment, general risk tolerance, and life satisfaction, all in unprecedentedly large samples. In addition, we
will undertake large-scale studies of additional phenotypes as data becomes available.
• Facilitate researchers' use of SSGAC results by (a) maintaining published results on the SSGAC's website,
and (b) providing participating datasets with certain unpublished results, in accordance with the SSGAC's
Data Availability Policy.
• Develop a “Repository of Polygenic Scores,” which are variables constructed from genetic data that are useful
to researchers. We will set up the Repository to provide polygenic scores to participating datasets.
• Update and expand the Repository as new genetic-association results become available. We will also welcome
any new datasets who wish to participate. Each release will be accompanied by documentation that clearly
describes methods used and the underlying data.
• Create and disseminate software that will allow datasets to create their own polygenic scores, using the same
harmonized methodology as the Repository but without needing to share their genetic data with the SSGAC.
The software will be publicly available on a GitHub repository featuring a Q&A forum where potential users
can ask questions. We will also prepare user-friendly software manual.
社会科学遗传协会联盟(SSGAC)是一个研究网络,提供了一个平台,
行为表型的全基因组关联研究的大规模跨学科合作。
由于可信的结果通常需要大量的发现样本,因此SSGAC的主要功能是进行
在不同的数据集中进行全基因组关联研究,然后严格地将结果联合收割机结合起来。本
最后,SSGAC还促进跨数据集收集协调和良好测量的表型,
开发新的方法工具。SSGAC致力于传播其研究成果,
以及随附的软件和手册。
本提案的总体目标是维护和开发SSGAC的核心基础设施。的
SSGAC产生的资源将继续服务于行为基因组学领域,
尤其是衰老的行为基因组学。具体目标是:
·在更大范围内对健康和衰老相关行为表型进行全基因组关联研究
现在已经有了样品。目前计划的研究包括分析教育
成就,一般风险承受能力和生活满意度,所有这些都是前所未有的大样本。另外我们
将在获得数据后对其他表型进行大规模研究。
·通过以下方式促进研究人员使用SSGAC结果:(a)在SSGAC网站上维护已发表的结果,
以及(B)根据SSGAC的
数据可用性政策。
·开发一个“多基因评分库”,这是从有用的遗传数据构建的变量
研究人员。我们将建立存储库,为参与数据集提供多基因评分。
·随着新的遗传关联结果的出现,更新和扩展知识库。我们也欢迎
任何希望参与的新数据集。每个版本都将附有文档,
描述了使用的方法和基础数据。
·创建和传播软件,允许数据集使用相同的方法创建自己的多基因分数
与知识库统一的方法,但不需要与SSGAC共享其遗传数据。
该软件将在GitHub存储库上公开提供,其中包括一个Q&A论坛,潜在用户可以在该论坛上访问该软件。
可以问问题我们还将准备用户友好的软件手册。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Daniel J Benjamin其他文献
Daniel J Benjamin的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Daniel J Benjamin', 18)}}的其他基金
Infrastructure and Core Activities of the Social Science Genetic Association Consortium
社会科学遗传学协会联盟的基础设施和核心活动
- 批准号:
10394069 - 财政年份:2019
- 资助金额:
$ 34.78万 - 项目类别:
Infrastructure and Core Activities of the Social Science Genetic Association Consortium
社会科学遗传学协会联盟的基础设施和核心活动
- 批准号:
10410572 - 财政年份:2019
- 资助金额:
$ 34.78万 - 项目类别:
Infrastructure and Core Activities of the Social Science Genetic Association Consortium
社会科学遗传学协会联盟的基础设施和核心活动
- 批准号:
10665683 - 财政年份:2019
- 资助金额:
$ 34.78万 - 项目类别:
Using Subjective Well-Being Data to Monitor Changes in Health and Well-Being
使用主观幸福感数据监测健康和幸福感的变化
- 批准号:
9339488 - 财政年份:2016
- 资助金额:
$ 34.78万 - 项目类别:
Using Subjective Well-Being Data to Monitor Changes in Health and Well-Being
使用主观幸福感数据监测健康和幸福感的变化
- 批准号:
10393831 - 财政年份:2016
- 资助金额:
$ 34.78万 - 项目类别:
Using Subjective Well-Being Data to Monitor Changes in Health and Well-Being
使用主观幸福感数据监测健康和幸福感的变化
- 批准号:
9010868 - 财政年份:2016
- 资助金额:
$ 34.78万 - 项目类别:
Using Subjective Well-Being Data to Monitor Changes in Health and Well-Being
使用主观幸福感数据监测健康和幸福感的变化
- 批准号:
9756260 - 财政年份:2016
- 资助金额:
$ 34.78万 - 项目类别:
Using Subjective Well-Being Data to Monitor Changes in Health and Well-Being
使用主观幸福感数据监测健康和幸福感的变化
- 批准号:
9982735 - 财政年份:2016
- 资助金额:
$ 34.78万 - 项目类别:
Genome-Wide Analyses of Health and Well-Being Phenotypes
健康和福祉表型的全基因组分析
- 批准号:
10263934 - 财政年份:2015
- 资助金额:
$ 34.78万 - 项目类别:
Analysis of Genome-Wide Data in the Health and Retirement Study
健康与退休研究中的全基因组数据分析
- 批准号:
9134583 - 财政年份:2015
- 资助金额:
$ 34.78万 - 项目类别:
相似海外基金
Investigating HDAC3 phosphorylation as an epigenetic regulator of memory formation in the adult and aging brain
研究 HDAC3 磷酸化作为成人和衰老大脑记忆形成的表观遗传调节剂
- 批准号:
10752404 - 财政年份:2023
- 资助金额:
$ 34.78万 - 项目类别:
The Health of Aging Parents of Adult Children with Serious Conditions
患有严重疾病的成年子女的年迈父母的健康
- 批准号:
10660046 - 财政年份:2023
- 资助金额:
$ 34.78万 - 项目类别:
Understanding Longer-Living Older Adult Research: The Summer Program on Aging
了解长寿老年人研究:老龄化夏季项目
- 批准号:
476343 - 财政年份:2022
- 资助金额:
$ 34.78万 - 项目类别:
Role of sensory experience in the regulation of plasticity in the developing, adult and aging brain
感官体验在发育、成人和衰老大脑可塑性调节中的作用
- 批准号:
RGPIN-2019-04761 - 财政年份:2022
- 资助金额:
$ 34.78万 - 项目类别:
Discovery Grants Program - Individual
Adult Cognitive and Neurobiological Indicators of Aging: Impact of Adversity and Social Support
成人衰老的认知和神经生物学指标:逆境和社会支持的影响
- 批准号:
10365348 - 财政年份:2022
- 资助金额:
$ 34.78万 - 项目类别:
Adult Cognitive and Neurobiological Indicators of Aging: Impact of Adversity and Social Support
成人衰老的认知和神经生物学指标:逆境和社会支持的影响
- 批准号:
10700796 - 财政年份:2022
- 资助金额:
$ 34.78万 - 项目类别:
Endogenous barcoding to determine complex dynamics of adult neurogenesis in aging and Alzheimer's disease
内源条形码确定衰老和阿尔茨海默病中成人神经发生的复杂动态
- 批准号:
10651861 - 财政年份:2022
- 资助金额:
$ 34.78万 - 项目类别:
Investigating the interface of epigenetics and metabolism underlying memory formation in the adult, aging, and AD brain
研究成人、衰老和 AD 大脑中记忆形成的表观遗传学和代谢界面
- 批准号:
10420533 - 财政年份:2022
- 资助金额:
$ 34.78万 - 项目类别:
Endogenous barcoding to determine complex dynamics of adult neurogenesis in aging and Alzheimer's disease
内源条形码确定衰老和阿尔茨海默病中成人神经发生的复杂动态
- 批准号:
10846200 - 财政年份:2022
- 资助金额:
$ 34.78万 - 项目类别:
THE DEVELOPMENT OF MECHANISM-BASED ADULT STEM CELL TREATMENTS TO COMBAT AGING PATHOLOGIES
开发基于机制的成人干细胞疗法来对抗衰老病理学
- 批准号:
10721544 - 财政年份:2022
- 资助金额:
$ 34.78万 - 项目类别: