Understanding Ethnic Differences in Cancer: The Multiethnic Cohort Study

了解癌症的种族差异：多种族队列研究

• 批准号: 10001968
• 负责人: Christopher Alan Haiman
• 金额: $ 338.15万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10001968
• 关键词: African American; Anthropometry; Biological Markers; Blood; California; Cancer Etiology; Caucasians; Chronic Disease; Cohort Studies; Collection; Colorectal Cancer; Computerized Medical Record; Cost efficiency; Cryopreservation; Cultural Diversity; DNA; Data; Data Management Resources; Databases; Diagnosis; Diet; Dietary intake; Disease Outcome; Early Diagnosis; Early treatment; Ensure; Environmental Risk Factor; Ethnic group; Etiology; Feces; Food Supplements; Funding; Genetic; Genetic Risk; Genomics; Geographic Locations; Grant; Hawaii; Health; Health behavior; Hospitals; Infrastructure; Japanese American; Joints; Latino; Leadership; Lymphocyte; Maintenance; Malignant Neoplasms; Malignant neoplasm of prostate; Medical; Medicare; Methodology; Modeling; Monitor; Mouthwash; Native Hawaiian; Neighborhoods; Normal tissue morphology; Nutritional; Odds Ratio; Outcome; Paper; Participant; Phenotype; Planning Techniques; Population; Postdoctoral Fellow; Prevention; Publishing; Quality of life; Questionnaires; RNA; Research; Research Methodology; Research Personnel; Research Project Grants; Residual state; Resources; Risk; Risk Factors; Saliva; Sampling; Slide; Smoking; Smoking History; Socioeconomic Status; Specimen; Statistical Models; Students; Testing; Tissue Banks; Tissue Microarray; Tissue Sample; Training; Tumor Tissue; Tumor-Associated Process; Update; Urine; Vital Statistics; Woman; Work; analytical method; biobank; cancer epidemiology; cancer health disparity; cancer risk; cancer site; cancer therapy; clinical biomarkers; cohort; complex data; computerized; data sharing; deprivation; design; digital; ethnic difference; ethnic diversity; follow-up; genetic association; genetic risk factor; genetic variant; genomic data; gut microbiome; high dimensionality; improved; innovation; insight; malignant breast neoplasm; member; men; metabolomics; microbiome research; novel strategies; nutrition; oral microbiome; phenotypic data; programs; prospective; racial and ethnic; racial and ethnic disparities; racial health disparity; racial minority; repository; risk prediction model; segregation; socioeconomics; stool sample; tumor; willingness

This renewal application seeks support for the infrastructure of the Multiethnic Cohort (MEC) Study, which was established in Hawaii and southern California in 1993-1996 to study risk factors for cancer and other chronic diseases. The study was designed to take advantage of the ethnic and cultural diversity of the two geographic areas, as well as the expertise of the investigators in nutrition, ethnic/racial studies, and genetics. It is the most ethnically diverse cancer cohort in existence. It achieves high cost-efficiency by supplementing active follow-up information with computerized linkages to SEER, vital statistics, hospital-discharge diagnoses, medical claim data, electronic medical records and geospatial information. At baseline, the cohort included information on 215,000 men and women, comprised almost entirely of five ethnic/racial populations: Caucasians, Japanese Americans, Native Hawaiians, African Americans, and Latinos. The resource was later expanded to include a prospective biorepository of blood and urine specimens from ~70,000 of the participants. Leadership of the MEC entails a highly interactive, team approach; and the investigators have amply demonstrated their willingness to share data/samples, and to participate actively in consortia. This application describes our aims over the next 5 years for maintaining and enhancing the infrastructure of the MEC, as well as plans for methodological research. Research accomplishments include significant contributions to understanding both genetic and environmental risk factors for cancer. Over 280 papers describing our findings have been published during the current grant cycle. In addition, over the last 20 years, 98 research grants have been built around the MEC, and more than 75 students and postdoctoral fellows have been trained on the study. This grant renewal will make possible the continuation of a well-integrated program of research aimed at evaluating environmental and genetic risk factors for cancer and other common chronic diseases, taking advantage of new approaches, such as genomics, microbiomics, adductomics and metabolomics. The MEC will allow the testing of innovative research hypotheses aimed at ensuring that progress in prevention applies to major US ethnic/racial minorities.

此更新申请寻求对多民族队列（MEC）研究基础设施的支持，该研究是