Assessment of metabolic bone disease of prematurity using an acoustic method

声学方法评估早产儿代谢性骨病

基本信息

  • 批准号:
    10005122
  • 负责人:
  • 金额:
    $ 20.99万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-09-01 至 2024-08-31
  • 项目状态:
    已结题

项目摘要

Metabolic bone disease in preterm newborn or osteopenia of prematurity (OP), or neonatal rickets or rickets of prematurity, are terms used to describe a common and significant problem that refers to hypo-mineralized skeleton of premature infants that is hallmarked by radiographic evidence of decreased bone mineralization and often leads to fractures of long bone and ribs. In an effort to maximize bone mineralization and minimize OP, clinicians use biochemical measurements of serum calcium, inorganic phosphorus, and alkaline phosphatase to make decisions for optimizing infant nutrition, but are limited to radiographic evidence over time to monitor this progress. Currently, no screening test has been shown to provide both sensitive and specific evidence of developing OP over the first several weeks of life in the premature infants. Such information would greatly facilitate clinicians’ efforts to optimize nutrition for preterm infants in an effort to minimize the risk of OP. Current bone assessment tools include plain radiography, dual-energy X-ray absorption (DXA), and quantitative ultrasonography (QUS). Due to the use of ionizing radiation and bulky equipment, the first two methods are not suitable for infants and especially for the low-birth-weight pre-term neonates, a group at particular risk of mineral compromise. QUS is designed to measure the speed of sound in large extremity bones by transmitting a single-frequency ultrasound. Adaptation of this device to infants and especially premature infants is very poor. The most important shortcoming of conventional QUS for evaluation of infant bone is that the results are greatly affected by subcutaneous tissues, particularly by the subcutaneous fat layer. Another shortcoming of the current QUS technology is that the system operates on a single- frequency basis. Based on our investigations, to be described later in this application, acquiring ultrasound data in a wide range of frequencies, especially in the kilo-Hertz range, can provide valuable information about the mechanical structure of bone and may lead to improved bone assessment. The goal of the proposed project is to develop a new ultrasound based technology, called vibro-acoustic analysis (VAA), which is based on a fundamentally new mechanism that allows evaluation of infant bone properties in a wide frequency range without the interference from subcutaneous tissues. In Aim 1, optimization of the VAA method for quantitative assessment, we will optimize and validate the technique for in vivo study. In Aim 2, we will determine the efficacy of the VAA method for quantitative assessment of tibia bone in a pilot study.The proposed technique will be tested on term and preterm infants to detect and monitor the treatment in a longitudinal study. The technology to be developed in this project may provide clinicians with valuable information to monitor and treat developing OP at a stage where radiographic evidence is not yet apparent. Additionally, quantitative measurements over time using improved VAA technology may facilitate assessments of treatment efficacy, thus further guiding clinical interventions with the strong potential for improved patient outcomes.
早产儿代谢性骨病或早产儿骨量减少(OP),或新生儿软骨病或软骨病 早熟,是用来描述一种常见而重要的问题的术语,指的是矿化不足 以骨骼矿化减少为特征的早产儿骨骼 并经常导致长骨和肋骨骨折。为了最大限度地增加骨骼矿化并尽量减少 OP,临床医生使用血清钙、无机磷和碱性的生化测量 磷酸酶为优化婴儿营养做出决定,但仅限于放射证据。 是时候监测这一进展了。目前,还没有任何筛查试验被证明同时提供敏感和 早产儿在出生后头几周发生OP的具体证据。是这样的 信息将极大地促进临床医生努力优化早产儿的营养,努力 将OP的风险降至最低。目前的骨骼评估工具包括平片、双能X射线 吸收(DXA)和定量超声(QUS)。由于使用了电离辐射和体积 仪器,前两种方法不适合婴儿,特别是低出生体重的早产儿 新生儿,这是一个特别容易受到矿物质危害的群体。QUS是用来测量声速的 通过发射单频超声波获得大块四肢骨骼。该装置适用于婴幼儿和 尤其是早产儿很差。传统量化评价方法的最大缺陷 婴幼儿骨骼受皮下组织,尤其是皮下组织的影响很大。 肥胖层。当前QUS技术的另一个缺点是该系统运行在单一的- 频率基准。基于我们的研究,稍后将在本申请中描述,获取超声波 各种频率范围内的数据,特别是千赫兹范围内的数据,可以提供有关 改善骨骼的机械结构,并可能导致改进骨骼评估。建议的目标是 项目是开发一种基于超声波的新技术,称为振动-声学分析(VAA),它基于 关于一种全新的机制,允许在广泛的频率范围内评估婴儿的骨骼特性 没有皮下组织的干扰。在目标1中,对VAA方法进行了优化 评估,我们将优化和验证体内研究的技术。在目标2中,我们将确定 VAA方法在一项先导性研究中对胫骨定量评估的有效性 将在一项纵向研究中对足月儿和早产儿进行测试,以检测和监测治疗情况。这个 该项目将开发的技术可能为临床医生提供有价值的监测和治疗信息 在放射证据尚不明显的阶段发展OP。此外,量化 使用改进的VAA技术随着时间的推移进行测量可以促进对治疗效果的评估, 从而进一步指导临床干预,具有改善患者结局的强大潜力。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Azra Alizad其他文献

Azra Alizad的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Azra Alizad', 18)}}的其他基金

Noninvasive assessment of detrusor pressure and dysfunction
无创评估逼尿肌压力和功能障碍
  • 批准号:
    10389800
  • 财政年份:
    2022
  • 资助金额:
    $ 20.99万
  • 项目类别:
Noninvasive assessment of detrusor pressure and dysfunction
无创评估逼尿肌压力和功能障碍
  • 批准号:
    10570230
  • 财政年份:
    2022
  • 资助金额:
    $ 20.99万
  • 项目类别:
Using Label-free Ultrasound Angio-Morphometry Analysis for Improving Ultrasound Specificity in Breast Cancer Detection and Treatment Monitoring
使用无标记超声血管形态测量分析提高乳腺癌检测和治疗监测中的超声特异性
  • 批准号:
    10652455
  • 财政年份:
    2019
  • 资助金额:
    $ 20.99万
  • 项目类别:
Ultrasonic perfusion imaging of peripheral vascular disease
周围血管疾病的超声灌注成像
  • 批准号:
    10413895
  • 财政年份:
    2019
  • 资助金额:
    $ 20.99万
  • 项目类别:
Using Label-free Ultrasound Angio-Morphometry Analysis for Improving Ultrasound Specificity in Breast Cancer Detection and Treatment Monitoring
使用无标记超声血管形态测量分析提高乳腺癌检测和治疗监测中的超声特异性
  • 批准号:
    10183203
  • 财政年份:
    2019
  • 资助金额:
    $ 20.99万
  • 项目类别:
Using Label-free Ultrasound Angio-Morphometry Analysis for Improving Ultrasound Specificity in Breast Cancer Detection and Treatment Monitoring
使用无标记超声血管形态测量分析提高乳腺癌检测和治疗监测中的超声特异性
  • 批准号:
    10418772
  • 财政年份:
    2019
  • 资助金额:
    $ 20.99万
  • 项目类别:
Ultrasonic perfusion imaging of peripheral vascular disease
周围血管疾病的超声灌注成像
  • 批准号:
    10171895
  • 财政年份:
    2019
  • 资助金额:
    $ 20.99万
  • 项目类别:
Localized measurement and mapping of tissue nonlinear elasticity
组织非线性弹性的局部测量和绘图
  • 批准号:
    9297301
  • 财政年份:
    2016
  • 资助金额:
    $ 20.99万
  • 项目类别:
Localized measurement and mapping of tissue nonlinear elasticity
组织非线性弹性的局部测量和绘图
  • 批准号:
    9196131
  • 财政年份:
    2016
  • 资助金额:
    $ 20.99万
  • 项目类别:
Viscoelastic Parameters estimation and imaging for Thyroid Nodule differentiation
甲状腺结节分化的粘弹性参数估计和成像
  • 批准号:
    8787587
  • 财政年份:
    2014
  • 资助金额:
    $ 20.99万
  • 项目类别:

相似海外基金

Co-designing a lifestyle, stop-vaping intervention for ex-smoking, adult vapers (CLOVER study)
为戒烟的成年电子烟使用者共同设计生活方式、戒烟干预措施(CLOVER 研究)
  • 批准号:
    MR/Z503605/1
  • 财政年份:
    2024
  • 资助金额:
    $ 20.99万
  • 项目类别:
    Research Grant
RAPID: Affective Mechanisms of Adjustment in Diverse Emerging Adult Student Communities Before, During, and Beyond the COVID-19 Pandemic
RAPID:COVID-19 大流行之前、期间和之后不同新兴成人学生社区的情感调整机制
  • 批准号:
    2402691
  • 财政年份:
    2024
  • 资助金额:
    $ 20.99万
  • 项目类别:
    Standard Grant
Early Life Antecedents Predicting Adult Daily Affective Reactivity to Stress
早期生活经历预测成人对压力的日常情感反应
  • 批准号:
    2336167
  • 财政年份:
    2024
  • 资助金额:
    $ 20.99万
  • 项目类别:
    Standard Grant
Elucidation of Adult Newt Cells Regulating the ZRS enhancer during Limb Regeneration
阐明成体蝾螈细胞在肢体再生过程中调节 ZRS 增强子
  • 批准号:
    24K12150
  • 财政年份:
    2024
  • 资助金额:
    $ 20.99万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Migrant Youth and the Sociolegal Construction of Child and Adult Categories
流动青年与儿童和成人类别的社会法律建构
  • 批准号:
    2341428
  • 财政年份:
    2024
  • 资助金额:
    $ 20.99万
  • 项目类别:
    Standard Grant
Understanding how platelets mediate new neuron formation in the adult brain
了解血小板如何介导成人大脑中新神经元的形成
  • 批准号:
    DE240100561
  • 财政年份:
    2024
  • 资助金额:
    $ 20.99万
  • 项目类别:
    Discovery Early Career Researcher Award
Laboratory testing and development of a new adult ankle splint
新型成人踝关节夹板的实验室测试和开发
  • 批准号:
    10065645
  • 财政年份:
    2023
  • 资助金额:
    $ 20.99万
  • 项目类别:
    Collaborative R&D
Usefulness of a question prompt sheet for onco-fertility in adolescent and young adult patients under 25 years old.
问题提示表对于 25 岁以下青少年和年轻成年患者的肿瘤生育力的有用性。
  • 批准号:
    23K09542
  • 财政年份:
    2023
  • 资助金额:
    $ 20.99万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Identification of new specific molecules associated with right ventricular dysfunction in adult patients with congenital heart disease
鉴定与成年先天性心脏病患者右心室功能障碍相关的新特异性分子
  • 批准号:
    23K07552
  • 财政年份:
    2023
  • 资助金额:
    $ 20.99万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Issue identifications and model developments in transitional care for patients with adult congenital heart disease.
成人先天性心脏病患者过渡护理的问题识别和模型开发。
  • 批准号:
    23K07559
  • 财政年份:
    2023
  • 资助金额:
    $ 20.99万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了