Assessment of metabolic bone disease of prematurity using an acoustic method

声学方法评估早产儿代谢性骨病

基本信息

  • 批准号:
    10005122
  • 负责人:
  • 金额:
    $ 20.99万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-09-01 至 2024-08-31
  • 项目状态:
    已结题

项目摘要

Metabolic bone disease in preterm newborn or osteopenia of prematurity (OP), or neonatal rickets or rickets of prematurity, are terms used to describe a common and significant problem that refers to hypo-mineralized skeleton of premature infants that is hallmarked by radiographic evidence of decreased bone mineralization and often leads to fractures of long bone and ribs. In an effort to maximize bone mineralization and minimize OP, clinicians use biochemical measurements of serum calcium, inorganic phosphorus, and alkaline phosphatase to make decisions for optimizing infant nutrition, but are limited to radiographic evidence over time to monitor this progress. Currently, no screening test has been shown to provide both sensitive and specific evidence of developing OP over the first several weeks of life in the premature infants. Such information would greatly facilitate clinicians’ efforts to optimize nutrition for preterm infants in an effort to minimize the risk of OP. Current bone assessment tools include plain radiography, dual-energy X-ray absorption (DXA), and quantitative ultrasonography (QUS). Due to the use of ionizing radiation and bulky equipment, the first two methods are not suitable for infants and especially for the low-birth-weight pre-term neonates, a group at particular risk of mineral compromise. QUS is designed to measure the speed of sound in large extremity bones by transmitting a single-frequency ultrasound. Adaptation of this device to infants and especially premature infants is very poor. The most important shortcoming of conventional QUS for evaluation of infant bone is that the results are greatly affected by subcutaneous tissues, particularly by the subcutaneous fat layer. Another shortcoming of the current QUS technology is that the system operates on a single- frequency basis. Based on our investigations, to be described later in this application, acquiring ultrasound data in a wide range of frequencies, especially in the kilo-Hertz range, can provide valuable information about the mechanical structure of bone and may lead to improved bone assessment. The goal of the proposed project is to develop a new ultrasound based technology, called vibro-acoustic analysis (VAA), which is based on a fundamentally new mechanism that allows evaluation of infant bone properties in a wide frequency range without the interference from subcutaneous tissues. In Aim 1, optimization of the VAA method for quantitative assessment, we will optimize and validate the technique for in vivo study. In Aim 2, we will determine the efficacy of the VAA method for quantitative assessment of tibia bone in a pilot study.The proposed technique will be tested on term and preterm infants to detect and monitor the treatment in a longitudinal study. The technology to be developed in this project may provide clinicians with valuable information to monitor and treat developing OP at a stage where radiographic evidence is not yet apparent. Additionally, quantitative measurements over time using improved VAA technology may facilitate assessments of treatment efficacy, thus further guiding clinical interventions with the strong potential for improved patient outcomes.
代谢性骨病见于早产新生儿或早产儿骨质减少症(OP),或新生儿佝偻病或佝偻病

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Azra Alizad其他文献

Azra Alizad的其他文献

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{{ truncateString('Azra Alizad', 18)}}的其他基金

Noninvasive assessment of detrusor pressure and dysfunction
无创评估逼尿肌压力和功能障碍
  • 批准号:
    10389800
  • 财政年份:
    2022
  • 资助金额:
    $ 20.99万
  • 项目类别:
Noninvasive assessment of detrusor pressure and dysfunction
无创评估逼尿肌压力和功能障碍
  • 批准号:
    10570230
  • 财政年份:
    2022
  • 资助金额:
    $ 20.99万
  • 项目类别:
Using Label-free Ultrasound Angio-Morphometry Analysis for Improving Ultrasound Specificity in Breast Cancer Detection and Treatment Monitoring
使用无标记超声血管形态测量分析提高乳腺癌检测和治疗监测中的超声特异性
  • 批准号:
    10652455
  • 财政年份:
    2019
  • 资助金额:
    $ 20.99万
  • 项目类别:
Ultrasonic perfusion imaging of peripheral vascular disease
周围血管疾病的超声灌注成像
  • 批准号:
    10413895
  • 财政年份:
    2019
  • 资助金额:
    $ 20.99万
  • 项目类别:
Using Label-free Ultrasound Angio-Morphometry Analysis for Improving Ultrasound Specificity in Breast Cancer Detection and Treatment Monitoring
使用无标记超声血管形态测量分析提高乳腺癌检测和治疗监测中的超声特异性
  • 批准号:
    10183203
  • 财政年份:
    2019
  • 资助金额:
    $ 20.99万
  • 项目类别:
Using Label-free Ultrasound Angio-Morphometry Analysis for Improving Ultrasound Specificity in Breast Cancer Detection and Treatment Monitoring
使用无标记超声血管形态测量分析提高乳腺癌检测和治疗监测中的超声特异性
  • 批准号:
    10418772
  • 财政年份:
    2019
  • 资助金额:
    $ 20.99万
  • 项目类别:
Ultrasonic perfusion imaging of peripheral vascular disease
周围血管疾病的超声灌注成像
  • 批准号:
    10171895
  • 财政年份:
    2019
  • 资助金额:
    $ 20.99万
  • 项目类别:
Localized measurement and mapping of tissue nonlinear elasticity
组织非线性弹性的局部测量和绘图
  • 批准号:
    9297301
  • 财政年份:
    2016
  • 资助金额:
    $ 20.99万
  • 项目类别:
Localized measurement and mapping of tissue nonlinear elasticity
组织非线性弹性的局部测量和绘图
  • 批准号:
    9196131
  • 财政年份:
    2016
  • 资助金额:
    $ 20.99万
  • 项目类别:
Viscoelastic Parameters estimation and imaging for Thyroid Nodule differentiation
甲状腺结节分化的粘弹性参数估计和成像
  • 批准号:
    8787587
  • 财政年份:
    2014
  • 资助金额:
    $ 20.99万
  • 项目类别:

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