A Study of Protective Clothing to Prevent Nanoparticle Exposure and Surface Contamination

防止纳米颗粒暴露和表面污染的防护服研究

• 批准号: 10006318
• 负责人: Candace SuJung Tsai
• 金额: $ 17.62万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-15 至 2021-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10006318
• 关键词: Study; Protective; Clothing; Prevent; Nanoparticle

A Study of Protective Clothing to Prevent Nanoparticle Exposure and Surface Contamination Principal Investigator: Candace Su-Jung Tsai, Sc.D., Assistant Professor of Industrial Hygiene and Environmental Health, Colorado State University, and Faculty Member at Birck Nanotechnology Center, Purdue University Investigators: Yan Vivian Li, PhD., Assistant Professor in Fiber Science, Colorado State University Ron Reifenberger, PhD., Professor of Physics, Director of Kevin Hall Nanometrology Laboratory, Purdue University PROJECT SUMMARY The proliferation of new applications in nanotechnology has highlighted the need to protect researchers in laboratories and workers in production facilities from exposure to engineered nanoparticles (ENPs) through skin contact or inhalation. Workers wearing contaminated clothing are at high risk of inhaling ENPs released from that clothing without any awareness of the potential danger. We have recently documented the significant release of metal oxide ENPs from laboratory clothing and highlighted serious concerns regarding the need to better understand the factors associated with ENP exposure from workplace attire. Importantly, when leaving the laboratory/production line, researchers and workers are unaware of the possible ENP exposure from contaminated clothing that they bring back to the office, home or public places. This contaminated clothing also poses a significant risk to non-workers in these outside of the workplace settings. It is well documented in the past, for example, that exposure to asbestos fibers from contaminated clothing has caused many workers and non-workers to suffer from asbestos-related diseases. It is worrying to note that ENPs are 1/10 to 1/100 the size of asbestos particles. Thus, the number of exposed ENPs could be >1000 more than that of such micron asbestos fibers, yet they are still invisible to the human eye. The goal of this study is to address key knowledge gaps in our understanding of ENP contamination of laboratory protective clothing and identify ways to prevent and minimize the problem. To achieve this goal, this project will study the propensity for contamination of major protective clothing fabrics by clinically-significant ENPs as well as the potential for subsequent exposure to individuals who come into contact with these fabrics. Our study will focus on key mechanistic aspects of ENP-fabric interactions such as mechanical force and electrical charge. The quantitative assessment of ENP adhesion and release from contaminated clothing will allow us to identify optimal fabric characteristics for protection against toxic ENPs. Importantly, we will use novel sampling techniques and state of the art technologies, including direct-reading air monitoring instruments, a nanoparticle sampler possessing a proprietary modification that we made to improve performance, and a thermal precipitator designed for nanoparticle collection to determine exposure, and advanced microscopic analysis - including atomic force microscopy (AFM) to investigate the mechanical forces and electrical charges associated with ENP-fabric interactions. Practically, we will use plasma surface treatment to functionalize fabric fiber surface to improve surface properties.

纳米粒子暴露与表面污染防护服的研究 主要研究者： Candace Su-Jung Tsai，Sc.D.，工业卫生和环境卫生助理教授，科罗拉多 美国州立大学教授、普渡大学Birck纳米技术中心教授 研究者： Yan Vivian Li，PhD.，科罗拉多州立大学纤维科学助理教授 罗恩·雷芬伯格博士，物理学教授，凯文霍尔纳米计量学实验室主任，普渡大学 大学 项目摘要 纳米技术新应用的激增突出了保护研究人员的必要性， 实验室和生产设施中的工人通过皮肤接触工程纳米颗粒（ENPs） 接触或吸入。穿着受污染衣服的工人有很高的风险吸入环境污染物， 在没有意识到潜在危险的情况下穿着这些衣服。我们最近记录了 从实验室服装中释放出的金属氧化物ENPs，并强调了对需要 更好地了解与工作场所着装中ENP暴露相关的因素。重要的是，离开时 实验室/生产线，研究人员和工人不知道可能的ENP暴露， 他们带回办公室、家中或公共场所的受污染衣物。这些被污染的衣服也 对工作场所以外的非工人构成重大风险。这在《 例如，在过去，暴露于受污染的衣服中的石棉纤维已经导致许多工人和 非工人患上与石棉有关的疾病。令人担忧的是，ENP的大小是其1/10至1/100 石棉颗粒。因此，暴露的ENP的数量可以比这种微米的ENP多>1000个。 石棉纤维，但它们仍然是不可见的人的眼睛。本研究的目的是解决关键知识 我们对实验室防护服ENP污染的理解存在差距，并确定预防方法 最小化问题。 为了实现这一目标，本项目将研究主要防护服的污染倾向 具有临床意义的ENP的织物，以及随后暴露于来自 与这些织物接触。我们的研究将集中在ENP织物相互作用的关键机制方面， 机械力和电荷。ENP粘附和释放的定量评估 受污染的衣服将使我们能够确定最佳的织物特性，以防止有毒的ENPs。 重要的是，我们将使用新的采样技术和最先进的技术，包括直接读取空气 监测仪器，一个纳米粒子采样器拥有一个专有的修改，我们作出了改进， 性能，以及设计用于纳米颗粒收集以确定暴露的热沉淀器，以及 先进的显微分析-包括原子力显微镜（AFM），以研究机械力 以及与ENP-织物相互作用相关的电荷。实际上，我们将使用等离子体表面处理 对织物纤维表面进行功能化处理，改善表面性能。