Strategies to reduce serious bacterial infections and overdose among people who inject drugs

减少注射吸毒者严重细菌感染和过量用药的策略

• 批准号: 10038052
• 负责人: Joshua Adam Barocas
• 金额: $ 17.26万
• 依托单位: BOSTON MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-15 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10038052
• 关键词: Address; Affect; Alcohol or Other Drugs use; Amputation; Applied Research; Attention; Bacterial Infections; Biometry; Cardiac Surgery procedures; Caring; Cessation of life; Chronic; Clinical; Clinical Research; Clinical Trials; Clinical effectiveness; Communicable Diseases; Communities; Cost Effectiveness Analysis; Cost of Illness; Data; Disease; Drug usage; Education; Educational workshop; Effectiveness; Endocarditis; Ensure; Epidemic; Epidemiology; Evaluation; Evolution; Fentanyl; Funding; Future; Goals; HIV; HIV/HCV; Health Care Costs; Health Policy; Healthcare Systems; Hepatitis C virus; Heroin; Hospitalization; Hospitals; Hygiene; Incidence; Infection; Infection prevention; Infective endocarditis; Injecting drug user; Injections; Intervention; Investigation; Mathematical Model Simulation; Measures; Medicine; Mentorship; Methodology; Methods; Modeling; Nature; Needles; Opioid; Oral Ingestion; Outcome; Overdose; Patients; Persons; Pharmaceutical Preparations; Population; Positioning Attribute; Preventive Intervention; Public Health; Quality of life; Relapse; Research; Research Personnel; Resources; Risk; Risk Factors; Sepsis; Skin; Skin Tissue; Soft Tissue Infections; Sterility; Structure; Time; Touch sensation; Training; addiction; base; clinical decision-making; combat; cost; cost effectiveness; cost outcomes; design; economic evaluation; economic outcome; experience; health care service utilization; health economics; high risk population; improved outcome; injection drug use; innovation; mathematical model; medical complication; models and simulation; multidisciplinary; non-opioid analgesic; novel; opioid epidemic; opioid injection; opioid use; opioid use disorder; prescription opioid; prevent; programs; skill acquisition; skills; tool

PROJECT SUMMARY Serious bacterial infections including infective endocarditis and skin and soft tissue infections are among the most common medical complications in persons who inject drugs (PWID). Hospitalizations for injection-related infective endocarditis increased twelve-fold between 2010 and 2015 and for heroin-related skin and soft tissue infections doubled over the last two decades. Costs of these diseases have also increased dramatically. While there are ongoing hospital-based programs to reduce injection-related bacterial infections, their long-term effectiveness, costs, and cost-effectiveness are unknown. Longitudinal investigation of these interventions is urgently needed to improve outcomes given the rapid expansion of the US opioid epidemic, but is challenging due to the relapsing nature of OUD, the heterogeneous nature of persons who inject opioids, and the shifting nature of the drug supply. Simulation modeling can augment evidence from trials by projecting the clinical and economic outcomes over longer time horizons for different populations. This proposed research will use simulation modeling to examine the impact of changes in injection opioid use practices as well as hospital-based interventions aimed at addressing the underlying OUD on the incidence of injection-related bacterial infections with the following scientific aims: Aim 1: To develop a simulation model of injection opioid use to project long-term incidence, outcomes, and costs of injection-related infective endocarditis, skin and soft tissue infections, and overdose. Aim 2: To estimate the clinical impact, costs, and cost-effectiveness of hospital-initiated addiction care and rapid-access linkage to post-hospital medication treatment for persons who inject opioids. Aim 3: To perform a comprehensive economic evaluation alongside an ongoing clinical trial and to use the simulation model to estimate the long-term clinical effectiveness of a hospital-based skin and needle hygiene program aimed to prevent bacterial infections among persons who inject opioids. During the K01 project period, the candidate will develop a specific skill set in three primary domains: (1) advanced quantitative methods for simulation modeling; (2) understanding the design, operationalization, and evaluation of hospital-based interventions for PWID; and (3) measuring healthcare utilization and cost- effectiveness analyses alongside clinical trials. Training will be accomplished through an intensive combination of formal structured courses, training workshops and field experiences, applied research experience, and focused mentorship in mathematical modeling, biostatistics, addiction, hospital-based interventions, and health economics. Acquisition of these skills will allow the candidate to accomplish his long-term goal, which is to become an independently-funded investigator and global expert on clinical decision making and health policy at the intersection of substance use and infectious diseases.

项目总结 严重的细菌感染，包括感染性心内膜炎和皮肤和软组织感染 注射吸毒者最常见的医疗并发症(PWID)。因以下原因住院治疗 2010至2015年间，注射相关感染性心内膜炎增加了12倍，海洛因相关 皮肤和软组织感染在过去20年中翻了一番。这些疾病的成本也增加了。 戏剧性的。 虽然有正在进行的以医院为基础的计划来减少与注射相关的细菌感染，但他们的 长期的有效性、成本和成本效益是未知的。对这些问题的纵向调查 鉴于美国阿片类药物流行的迅速扩大，迫切需要干预措施来改善结果，但 由于OUD的复发性，注射阿片类药物的人的异质性， 以及毒品供应性质的变化。模拟建模可以通过投射来增加来自试验的证据 不同人群在较长时间内的临床和经济结果。这项拟议的研究 将使用模拟建模来检查注射阿片类药物使用做法变化的影响以及 以医院为基础的干预措施，旨在解决与注射相关的潜在OUD发生率 具有以下科学目标的细菌感染： 目的1：建立注射阿片类药物使用的模拟模型，以预测长期发生率、结果和 与注射相关的感染性心内膜炎、皮肤和软组织感染以及过量用药的费用。目标2：实现 评估医院发起的成瘾护理和快速访问的临床影响、成本和成本效益 与注射阿片类药物的人的院后用药治疗有关。目标3：执行 在进行临床试验的同时进行综合经济评估，并使用模拟模型来 评估以医院为基础的皮肤和针头卫生计划的长期临床效果 预防注射阿片类药物者的细菌感染。 在K01项目期间，候选人将在三个主要领域发展特定的技能集： (1)先进的仿真建模定量方法；(2)了解设计、操作、 和评估以医院为基础的PWID干预措施；以及(3)衡量医疗保健利用率和成本- 在进行临床试验的同时进行有效性分析。训练将通过密集的组合来完成 正规的结构化课程、培训讲习班和实地经验、应用研究经验以及 专注于数学建模、生物统计学、成瘾、医院干预和健康方面的指导 经济学。掌握这些技能将使应聘者能够实现他的长期目标，即 成为临床决策和卫生政策方面的独立研究人员和全球专家 在物质使用和传染病的交叉点上。