Core B: Human Biology Validation Core

核心 B：人类生物学验证核心

• 批准号: 10011938
• 负责人: Lea Tenenholz Grinberg
• 金额: $ 27.91万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-30 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10011938
• 关键词: Aging; Alzheimer' s Disease; Autophagocytosis; Autophagosome; Autopsy; Back; Biocompatible Materials; Biological Assay; Brain; Cells; Cerebellum; Clinical; Collection; Complex; Data; Data Analyses; Databases; Disease; Emotions; Event; Experimental Models; Fostering; Freezing; Frontotemporal Dementia; Funding; Genes; Genetic; Goals; Human; Human Biology; Image; Lead; Leadership; Link; Liquid substance; Memory; Middle frontal gyrus structure; Modeling; Neurodegenerative Disorders; Neurons; Neurosciences; Pathogenicity; Pathology; Patient Isolators; Patients; Principal Investigator; Research; Research Personnel; Research Support; Sampling; Shipping; Specimen; Structure of inferior temporal gyrus; Synaptosomes; System; Tauopathies; Tissue Stains; Tissues; Training; Translations; United States National Institutes of Health; Validation; Work; automated analysis; brain tissue; design; experimental study; human tissue; in vitro Assay; interest; programs; proteostasis; spatial relationship; tau Proteins; tau dysfunction; tau mutation; therapeutic target; tool; translational neuroscience

Project summary/abstract Human Core – Grinberg U54 CWOW The Human Biology Validation core will provide vital research support to the CWOW. Neurodegenerative disease pathology and genetics have become increasingly exciting and complex in recent years, with major advances arising from work accomplished through this ADRC. In this renewal application, the Human Core will be led by Dr. Lea T. Grinberg and Dr. Bruce L. Miller. Dr. Anne Fagan will lead a CSF array sub-core The Human Core goals are to: (1) directly supporting this CWOW’s Projects (P) with well-characterized and carefully treated human tissue, bio-fluids, and cells from tauopathy patients and controls; (2) validating the relevance results from P 1-3 in human specimens; (3) developing enhanced tools for boosting the amount of information retrieved for each single biospecimen samples. These core functions will support the aims of Projects 1 (PI: Gan) and 3 (PI: Cuervo) by providing well-characterized human brain and bio fluid specimens from tauopathies. Moreover, the Human Core will help to validate the findings from the CWOW’s projects to accelerate translation from bench to clinical use.

项目概要/摘要 Human Core - Grinberg U54 CWOW 人类生物学验证核心将为CWOW提供重要的研究支持。神经变性 近年来，疾病病理学和遗传学变得越来越令人兴奋和复杂， 通过该ADRC完成的工作所产生的预付款。在这次更新申请中，人类核心将 由莱亚·T博士领导。格林伯格和布鲁斯L.米勒。安妮·费根博士将领导一个脑脊液阵列子核心 人类核心目标是：（1）直接支持CWOW的项目（P）， 仔细处理的来自tau蛋白病患者和对照的人组织、生物流体和细胞;（2）验证 相关性结果从P1 -3在人类标本;（3）开发增强的工具， 为每个生物标本样本检索的信息。这些核心职能将支持 项目1（PI：Gan）和3（PI：Cuervo）通过提供充分表征的人脑和生物液体标本 Tau病此外，Human Core将有助于验证CWOW项目的发现， 加速从实验室到临床应用的转化。