Neuropathological changes underlying clinical heterogeneity in Alzheimer disease

阿尔茨海默病临床异质性背后的神经病理学变化

• 批准号: 9330754
• 负责人: Lea Tenenholz Grinberg
• 金额: $ 16.49万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-15 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9330754
• 关键词: Affect; Aging; Alzheimer' s Disease; Anatomy; Area; Argyrophilic Grain Disease; Astrocytes; Autopsy; Biological Neural Networks; Brain; Budgets; California; Characteristics; Clinical; Clinical Research; Cohort Studies; Collaborations; Collection; Crutches; Data; Data Analyses; Dementia; Disease; Disease Progression; Faculty; Funding; Funding Mechanisms; Genetic Variation; Goals; Grant; Heterogeneity; Hippocampus (Brain); Human; International; Interruption; Lead; Lesion; Longitudinal cohort study; Manuscripts; Medical Genetics; Medical Students; Memory; Mentors; Mid-Career Clinical Scientist Award (K24); Nerve Degeneration; Neurobiology; Neurodegenerative Disorders; Neurofibrillary Tangles; Neurologist; Neuropsychology; Outcome; Pathology; Patients; Persons; Preparation; Prevention; Primary Progressive Aphasia; Program Development; Quality of life; Research; Research Infrastructure; Research Personnel; Research Training; Risk; Risk Factors; Role; San Francisco; Scheme; Senile Plaques; Severities; Staging; Structure; Symptoms; Testing; Time; Tissues; Training; Training Programs; United States National Institutes of Health; Universities; University resources; Variant; Work; Writing; age related; associated symptom; career; cerebral atrophy; clinical effect; clinical phenotype; cohort; disorder subtype; experience; genetic variant; hands on research; mid-career faculty; multidisciplinary; neuropathology; neuropsychiatric symptom; neuropsychiatry; novel; novel marker; patient oriented; programs; protein TDP-43; research study; residence; skills; tau Proteins

ABSTRACT This is an application for a K24 award for Dr. Lea T. Grinberg, a neuropathologist at the University of California, San Francisco (UCSF). Dr. Grinberg is an Associate Professor in Residence and co-lead the UCSF/Memory and Aging Center's Neuropathology Core. She is an established researcher in the patient- oriented clinical research of dementia. A distinctive hallmark of her research is her direct involvement in creating, managing and analyzing well-characterized postmortem collections of brains belonging to people at- risk or already with dementia. Dr. Grinberg proposes to use K24 dedicated time to mentor USCF as well as international investigators in patient-oriented dementia research. Her mentees will gain hands-on research experience, expertise in age-related human neuropathology, training in data analysis, manuscript preparation, and grant writing, as well as career, mentoring. Mentee training will leverage the infrastructure and resources of the UCSF/Memory and Aging Center Autopsy program, which is part of ongoing longitudinal cohort studies (P50AG02350 and P01AG019724), and her collaborations with multidisciplinary researchers in the areas of dementia domestically and worldwide. To increase her mentoring skills, she proposes to participate in the UCSF Mentor Development Program. Dr. Grinberg intends to conduct K24-supported Alzheimer's disease research studies that will serve as training vehicles for mentees and expand her research. These studies, using clinical, genetic and neuropathological data, will be conducted using data from ongoing UCSF/Memory and Aging Center's NIH-funded cohort studies of persons with Alzheimer's disease(AD) . She will examine the role of recently described neurodegenerative changes in modifying the clinical phenotype of AD. In summary, this K24 will enhance Dr. Ginberg's active research program with extensive infrastructure at UCSF to support her goal to remain a leader in neurodegenerative diseases, especially in the field of neuropathology, and to develop a program of excellence for training medical students, trainees, and junior faculty in POR related to age-related neuropathology that is also intended to close the gaps caused by interruption of neuropathology training for neurologists and neurodegenerative disease training for neuropathologists.

抽象的 这是 Lea T. Grinberg 博士的 K24 奖项申请，她是纽约大学的神经病理学家。 加利福尼亚州、旧金山 (UCSF)。 Grinberg 博士是常驻副教授，并共同领导 加州大学旧金山分校/记忆与衰老中心的神经病理学核心。她是一位在患者领域颇有建树的研究员—— 面向痴呆症的临床研究。她的研究的一个显着特点是她直接参与 创建、管理和分析属于以下人员的特征良好的死后大脑集合： 风险或已经患有痴呆症。 Grinberg 博士建议利用 K24 专门时间来指导 USCF 以及 以患者为导向的痴呆症研究的国际研究者。她的学员将获得实践研究 经验、与年龄相关的人类神经病理学方面的专业知识、数据分析培训、手稿准备、 以及资助写作，以及职业指导。学员培训将利用基础设施和资源 加州大学旧金山分校/记忆与衰老中心尸检计划的一部分，该计划是正在进行的纵向队列研究的一部分 （P50AG02350 和 P01AG019724），以及她与以下领域的多学科研究人员的合作 国内和世界范围内的痴呆症。为了提高她的指导技能，她建议参加 加州大学旧金山分校导师发展计划。 Grinberg 博士打算进行 K24 支持的阿尔茨海默病治疗 研究将作为学员的培训工具并扩大她的研究范围。这些研究， 使用临床、遗传和神经病理学数据，将使用正在进行的 UCSF/Memory 的数据进行 和老龄化中心由美国国立卫生研究院 (NIH) 资助的针对阿尔茨海默病 (AD) 患者的队列研究。她将检查 最近描述的神经退行性变化在改变 AD 临床表型中的作用。总之， 这个 K24 将通过 UCSF 广泛的基础设施来加强 Ginberg 博士的积极研究计划，以支持 她的目标是保持神经退行性疾病领域的领导者地位，特别是在神经病理学领域，并 制定一项卓越计划，用于培训医学生、实习生和初级教师 POR 相关领域 与年龄相关的神经病理学，也旨在弥补因神经病理学中断而造成的差距 神经科医生培训和神经病理学家神经退行性疾病培训。