Development of Advanced MRI for the Thoracolumbar Spinal Cord for Clinical Application

开发用于临床应用的胸腰段脊髓先进 MRI

• 批准号: 10040081
• 负责人: Kristin Poole O'Grady
• 金额: $ 15.51万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-08 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10040081
• 关键词: Academic Medical Centers; Accidents; Address; Advanced Development; Affect; Age; Anatomy; Anisotropy; Area; Atrophic; Autonomic Pathways; Axon; Back Pain; Biological; Bladder; Bladder Dysfunction; Brain; Caring; Central Nervous System Diseases; Cervical spinal cord structure; Chest; Chronic; Clinical; Clinical Management; Demyelinations; Development; Diagnosis; Diffuse; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Disease Progression; Disease susceptibility; Enrollment; Environment; Female; Functional Magnetic Resonance Imaging; Functional disorder; Gait; Goals; Grant; Height; Image; Immune; Immunologic Factors; Immunologics; Immunology; Impairment; Infection; Institutes; Institution; Knowledge; Lesion; Lower Extremity; Magnetic Resonance Imaging; Measures; Mediating; Mentors; Mentorship; Methods; Microscopic; Motion; Motivation; Multiple Sclerosis; Multiple Sclerosis Lesions; Myelin; Nerve Degeneration; Neurologic; Neurologic Deficit; Noise; Onset of illness; Outcome; Pathology; Patients; Physiologic pulse; Physiology; Population; Prevalence; Protocols documentation; Quality of life; Radiology Specialty; Recovery; Relapsing-Remitting Multiple Sclerosis; Reproducibility; Research; Resolution; Rest; Role; Science; Sex Differences; Signal Transduction; Speed; Spinal Cord; Spinal Cord Lesions; Spinal cord damage; Structure; Symptoms; Technical Expertise; Time; Tissues; Training; Translations; Transverse Myelitis; Trauma; Variant; Weight; Widespread Disease; Woman; Work; age difference; anatomic imaging; base; bioimaging; biological sex; burden of illness; career development; clinical application; clinical translation; cohort; disability; disease phenotype; early experience; experience; hand dysfunction; healthy volunteer; illness length; image processing; imaging modality; imaging scientist; improved; indexing; male; men; method development; multimodality; multiple sclerosis patient; nervous system disorder; neuromuscular; potential biomarker; programs; research and development; sex; spinal cord imaging; white matter

PROJECT SUMMARY In multiple sclerosis (MS), an estimated 40% of spinal cord (SC) lesions are located in the thoracic and lumbar segments of the SC. These regions of the SC are associated with lower limb and bladder function, the most prevalent targets for neurological deficits in MS, but the thoracolumbar SC is significantly understudied and lesions here are rarely identified with clinical magnetic resonance imaging (MRI) protocols. Conventional clinical MRI for the thoracolumbar SC lacks sensitivity to lesions and microscopic pathology that may drive impairment, and is unable to discern the extent of demyelination or possible altered function of the lower cord. The overarching goal of this project is to develop and optimize MRI methods for quantitative characterization of tissue structure and function in the thoracolumbar SC in patients with MS. I will complete this goal in three aims: Aim 1) Develop and optimize anatomical, diffusion, and resting-state functional MRI methods for the thoracolumbar SC at clinical field strength (3T), Aim 2) Quantify the reproducibility of the thoracolumbar MRI protocol in healthy volunteers and characterize biological variation (e.g. age and sex differences) in thoracolumbar cord structure and function, and Aim 3) Apply the multimodal MRI toolset to study relationships between MRI indices, biological variables (age, sex), and clinical measures of lower limb and bladder dysfunction in MS patients. Completion of these aims and the mentored training in clinical and immunological features of MS outlined in this proposal will provide me with technical training in advanced MRI pulse programming and methods development for the spinal cord, and expanded didactic training in immunology, sex differences in MS, neuromuscular physiology, and clinical management of MS. In addition to the technical expertise above, this grant will allow me to transition to independence as a translational imaging scientist. My institution has guaranteed at least 90% protected time to the proposed research and career development activities. My professional development will be guided by an interdisciplinary mentorship committee led by my primary mentor Dr. Seth Smith and co-mentors Dr. John Gore and Dr. Subramaniam Sriram. Dr. Smith is an expert in pulse programming and deployment of advanced MRI methods in clinical populations, and Drs. Gore and Siram are renowned for their work in biomedical imaging methods and applications and immunological factors in MS lesion recovery, respectively. I am capitalizing on Vanderbilt’s strengths in translational imaging research and readily available clinical subjects by working with mentors and collaborators in the Institute of Imaging Science and in clinical departments of the Vanderbilt University Medical Center. This makes Vanderbilt a unique and stimulating environment for professional development and completion of my proposed studies.

项目总结